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01-05-2006 | Case Report

False positive ¹⁸F-FDG PET in an ischial chondroblastoma; an analysis of glucose transporter 1 and hexokinase II expression

Authors: Kenichiro Hamada, Takafumi Ueda, Yasuhiko Tomita, Ichiro Higuchi, Atsuo Inoue, Noriyuki Tamai, Akira Myoui, Katsuyuki Aozasa, Hideki Yoshikawa, Jun Hatazawa

Published in: Skeletal Radiology | Issue 5/2006

Abstract

We report a rare case of chondroblastoma arising from the ischium which showed an increased ¹⁸F-FDG uptake. Chondroblastoma is an uncommon lesion and usually involves the epiphysis of long bones. However, in this case, the tumor appeared as a well-defined osteolytic lesion in the ischium on radiographs. MR imaging demonstrated two components in the tumor: a solid one and a multilobular cystic component. ¹⁸F-FDG PET imaging revealed an increased uptake in the ischium. The ¹⁸F-FDG uptake resembled the results observed in malignant bone tumors. A histological diagnosis of chondroblastoma was obtained from tissue of an open biopsy. An immunohistochemical analysis demonstrated weak expression of both Glut-1 and HK-II. These findings suggest that Glut-1 and HK-II expression are not strongly related to FDG uptake in chondroblastoma.

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Title: False positive 18F-FDG PET in an ischial chondroblastoma; an analysis of glucose transporter 1 and hexokinase II expression
Authors: Kenichiro Hamada
Takafumi Ueda
Yasuhiko Tomita
Ichiro Higuchi
Atsuo Inoue
Noriyuki Tamai
Akira Myoui
Katsuyuki Aozasa
Hideki Yoshikawa
Jun Hatazawa
Publication date: 01-05-2006
Publisher: Springer-Verlag
Published in: Skeletal Radiology / Issue 5/2006
Print ISSN: 0364-2348
Electronic ISSN: 1432-2161
DOI: https://doi.org/10.1007/s00256-005-0032-x

At a glance: The STEP trials

Springer Medicine

False positive ¹⁸F-FDG PET in an ischial chondroblastoma; an analysis of glucose transporter 1 and hexokinase II expression

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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