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Pediatric Radiology
Published in: Pediatric Radiology 13/2020

01-12-2020 | Hemangioma | Fetal imaging

Imaging of solid congenital abdominal masses: a review of the literature and practical approach to image interpretation

Author: Krista L. Birkemeier

Published in: Pediatric Radiology | Issue 13/2020

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Abstract

Fetal abdominal tumors are rare, usually benign, and cause a great deal of anxiety for expectant parents and the physicians counseling them. In this paper the author reviews the most common fetal abdominal tumors in the liver (hemangioma, mesenchymal hamartoma, hepatoblastoma, metastases) and the kidney (congenital mesoblastic nephroma, Wilms tumor, malignant rhabdoid tumor, and clear cell sarcoma), and suprarenal mass lesions (adrenal neuroblastoma, adrenal hemorrhage, and subdiaphragmatic extralobar pulmonary sequestration). The author describes the imaging approach, imaging appearance and differentiating features of tumors, and differences between fetal and childhood appearances of tumors.
Literature
1.
Amari F, Beyer DA, Diedrich K, Weichert J (2013) Fetal intra-abdominal tumors: assessment of spectrum, accuracy of prenatal diagnosis, perinatal outcome and therapy at a tertiary referral center. Eur J Obstet Gynecol Reprod Biol 167:160–166PubMedCrossRef
2.
3.
Marks F, Thomas P, Lustig I et al (1990) In utero sonographic description of a fetal liver adenoma. J Ultrasound Med 9:119–122PubMedCrossRef
4.
Applegate KE, Ghei M, Perez-Atayde AR (1999) Prenatal detection of a solitary liver adenoma. Pediatr Radiol 29:92–94PubMedCrossRef
5.
Petrikovsky BM, Cohen HL, Scimeca P, Bellucci E (1994) Prenatal diagnosis of focal nodular hyperplasia of the liver. Prenat Diagn 14:406–409PubMedCrossRef
6.
Demir HA, Varan A, Akçören Z et al (2008) Focal nodular hyperplasia of the liver and elevated alpha fetoprotein level in an infant with isolated hemihyperplasia. J Pediatr Hematol Oncol 30:775–777PubMedCrossRef
7.
8.
Mo JQ, Dimashkieh HH, Bove KE (2004) GLUT1 endothelial reactivity distinguishes hepatic infantile hemangioma from congenital hepatic vascular malformation with associated capillary proliferation. Hum Pathol 35:200–209PubMedCrossRef
9.
Johnson CM, Navarro OM (2017) Clinical and sonographic features of pediatric soft-tissue vascular anomalies Part 1: classification, sonographic approach and vascular tumors. Pediatr Radiol 47:1184–1195PubMedCrossRef
10.
Merrow AC, Gupta A, Patel MN, Adams DM (2016) 2014 revised classification of vascular lesions from the International Society for the Study of Vascular Anomalies: radiologic-pathologic update. Radiographics 36:1494–1516
11.
Christison-Lagay ER, Burrows PE, Alomari A et al (2007) Hepatic hemangiomas: subtype classification and development of a clinical practice algorithm and registry. J Pediatr Surg 42:62–67PubMedCrossRef
12.
Kulungowski AM, Alomari AI, Chawla A et al (2012) Lessons from a liver hemangioma registry: subtype classification. J Pediatr Surg 47:165–170PubMedCrossRef
13.
Ackermann O, Fabre M, Franchi S et al (2011) Widening spectrum of liver angiosarcoma in children. J Pediatr Gastroenterol Nutr 53:615–619PubMed
14.
Stringer MD, Alizai NK (2005) Mesenchymal hamartoma of the liver: a systematic review. J Pediatr Surg 40:1681–1690PubMedCrossRef
15.
Cornette J, Festen S, van den Hoonaard TL, Steegers EAP (2009) Mesenchymal hamartoma of the liver: a benign tumor with deceptive prognosis in the perinatal period. Case report and review of the literature. Fetal Diagn Ther 25:196–202PubMedCrossRef
16.
17.
Herzog CE, Andrassy RJ, Eftekhari F (2000) Childhood cancers: hepatoblastoma. Oncologist 5:445–453PubMedCrossRef
18.
Trobaugh-Lotrario AD, Chaiyachati BH, Meyers RL et al (2013) Outcomes for patients with congenital hepatoblastoma. Pediatr Blood Cancer 60:1817–1825PubMedCrossRef
19.
20.
21.
Gedikbasi A, Oztarhan K, Ulker V et al (2011) Prenatal sonographic diagnosis of tuberous sclerosis complex. J Clin Ultrasound JCU 39:427–430PubMedCrossRef
22.
Linam LE, Yu X, Calvo-Garcia MA et al (2010) Contribution of magnetic resonance imaging to prenatal differential diagnosis of renal tumors: report of two cases and review of the literature. Fetal Diagn Ther 28:100–108PubMedCrossRef
23.
Leclair M-D, El-Ghoneimi A, Audry G et al (2005) The outcome of prenatally diagnosed renal tumors. J Urol 173:186–189PubMedCrossRef
24.
van den Heuvel-Eibrink MM, Grundy P, Graf N et al (2008) Characteristics and survival of 750 children diagnosed with a renal tumor in the first seven months of life: a collaborative study by the SIOP/GPOH/SFOP, NWTSG, and UKCCSG Wilms tumor study groups. Pediatr Blood Cancer 50:1130–1134PubMedCrossRef
25.
Berger M, von Schweinitz D (2015) Current management of fetal and neonatal renal tumors. Curr Pediatr Rev 11:188–194PubMedCrossRef
26.
27.
Suresh I, Suresh S, Arumugam R et al (1997) Antenatal diagnosis of Wilms tumor. J Ultrasound Med 16:69–72PubMedCrossRef
28.
Ritchey ML, Azizkhan RG, Beckwith JB et al (1995) Neonatal Wilms tumor. J Pediatr Surg 30:856–859PubMedCrossRef
29.
Chung CJ, Cammoun D, Munden M (1990) Rhabdoid tumor of the kidney presenting as an abdominal mass in a newborn. Pediatr Radiol 20:562–563PubMedCrossRef
30.
Stanescu AL, Acharya PT, Lee EY, Phillips GS (2019) Pediatric renal neoplasms: MR imaging-based practical diagnostic approach. Magn Reson Imaging Clin N Am 27:279–290PubMedCrossRef
31.
Gooskens SLM, Furtwängler R, Vujanic GM et al (2012) Clear cell sarcoma of the kidney: a review. Eur J Cancer 48:2219–2226PubMedCrossRef
32.
Furtwängler R, Gooskens SL, van Tinteren H et al (2013) Clear cell sarcomas of the kidney registered on International Society of Pediatric Oncology (SIOP) 93-01 and SIOP 2001 protocols: a report of the SIOP renal tumour study group. Eur J Cancer 49:3497–3506PubMedCrossRef
33.
Sherer DM, Dalloul M, Wagreich A et al (2008) Prenatal sonographic findings of congenital adrenal cortical adenoma. J Ultrasound Med 27:1091–1093PubMedCrossRef
34.
Sarwar ZU, Ward VL, Mooney DP et al (2004) Congenital adrenocortical adenoma: case report and review of literature. Pediatr Radiol 34:991–994PubMedCrossRef
35.
Izbizky G, Elias D, Gallo A et al (2005) Prenatal diagnosis of fetal bilateral adrenal carcinoma. Ultrasound Obstet Gynecol 26:669–671PubMedCrossRef
36.
Chen CP, Chen SH, Chuang CY et al (1997) Clinical and perinatal sonographic features of congenital adrenal cystic neuroblastoma: a case report with review of the literature. Ultrasound Obstet Gynecol 10:68–73PubMedCrossRef
37.
Gali S, Anat I (2015) Purely cystic adrenal lesion in a newborn evolving into a solid neuroblastoma. J Clin Ultrasound 43:126–128PubMedCrossRef
38.
Isaacs H (2007) Fetal and neonatal neuroblastoma: retrospective review of 271 cases. Fetal Pediatr Pathol 26:177–184PubMedCrossRef
39.
Desai G, Filly RA, Rand L (2009) Prenatal detection of an extra-adrenal neuroblastoma with hepatic metastases. J Ultrasound Med 28:1085–1090PubMedCrossRef
40.
Curtis MR, Mooney DP, Vaccaro TJ et al (1997) Prenatal ultrasound characterization of the suprarenal mass: distinction between neuroblastoma and subdiaphragmatic extralobar pulmonary sequestration. J Ultrasound Med 16:75–83PubMedCrossRef
41.
Eo H, Kim JH, Jang KM et al (2011) Comparison of clinico-radiological features between congenital cystic neuroblastoma and neonatal adrenal hemorrhagic pseudocyst. Korean J Radiol 12:52–58PubMedPubMedCentralCrossRef
42.
Hwang SM, Yoo S-Y, Kim JH, Jeon TY (2016) Congenital adrenal neuroblastoma with and without cystic change: differentiating features with an emphasis on the of value of ultrasound. AJR Am J Roentgenol 207:1105–1111PubMedCrossRef
43.
Flanagan SM, Rubesova E, Jaramillo D, Barth RA (2016) Fetal suprarenal masses — assessing the complementary role of magnetic resonance and ultrasound for diagnosis. Pediatr Radiol 46:246–254PubMedCrossRef
44.
45.
Heling KS, Chaoui R, Hartung J et al (1999) Prenatal diagnosis of congenital neuroblastoma. Analysis of 4 cases and review of the literature. Fetal Diagn Ther 14:47–52PubMedCrossRef
46.
Gyurkovits Z, Maróti Á, Rénes L et al (2015) Adrenal haemorrhage in term neonates: a retrospective study from the period 2001–2013. J Matern Fetal Neonatal Med 28:2062–2065PubMedCrossRef
47.
Lee MC, Lin LH (2000) Ultrasound screening of neonatal adrenal hemorrhage. Acta Paediatr Taiwanica 41:327–330
48.
Toti MS, Ghirri P, Bartoli A et al (2019) Adrenal hemorrhage in newborn: how, when and why — from case report to literature review. Ital J Pediatr 45:58PubMedPubMedCentralCrossRef
49.
Riley JS, Urwin JW, Oliver ER et al (2018) Prenatal growth characteristics and pre/postnatal management of bronchopulmonary sequestrations. J Pediatr Surg 53:265–269PubMedCrossRef
50.
Zhang N, Zeng Q, Chen C et al (2019) Distribution, diagnosis, and treatment of pulmonary sequestration: report of 208 cases. J Pediatr Surg 54:1286–1292PubMedCrossRef
51.
Dhingsa R, Coakley FV, Albanese CT et al (2003) Prenatal sonography and MR imaging of pulmonary sequestration. AJR Am J Roentgenol 180:433–437PubMedCrossRef
52.
Obeidat N, Sallout B, Alaali W (2016) Isolated subdiaphragmatic extralobar pulmonary sequestration: masquerading as suprarenal mass with spontaneous resolution. Clin Exp Obstet Gynecol 43:457–459PubMed
53.
Adzick NS, Harrison MR, Crombleholme TM et al (1998) Fetal lung lesions: management and outcome. Am J Obstet Gynecol 179:884–889PubMedCrossRef
54.
Laberge J-M, Puligandla P, Flageole H (2005) Asymptomatic congenital lung malformations. Semin Pediatr Surg 14:16–33PubMedCrossRef
55.
56.
Janda GM, Najdzionek JS, Kozielski R et al (2014) Early prenatal detection of an intra-abdominal cryptorchid testicular teratoma. Urology 83:214–216PubMedCrossRef
57.
Youssef A, Salsi G, Curti A et al (2016) Prenatal ultrasonographic features of mature cystic teratoma in undescended testicle. Ultrasound Obstet Gynecol 47:527–529PubMedCrossRef
58.
Siu SS, Leung TN, Leung TY et al (2001) Prenatal diagnosis of intra-abdominal mature testicular teratoma. J Ultrasound Med 20:1257–1260PubMedCrossRef
59.
Shih HH, Teng RJ, Yau KI et al (1997) Mature teratoma arising from an intra-abdominal undescended testis presenting as a fetal abdominal mass. Ultrasound Obstet Gynecol 10:209–211PubMedCrossRef
60.
Wagner N, Kagan KO, Warmann SW et al (2009) Prenatal diagnosis and management of a fetal intra-abdominal teratoma: a case report and review of the literature. Fetal Diagn Ther 26:170–172PubMedCrossRef
61.
Basu A, Jagdish S, Iyengar KR, Basu D (2006) Fetus in fetu or differentiated teratomas? Indian J Pathol Microbiol 49:563–565PubMed
62.
Birkemeier K (2015) Abdominal masses. In: Kline-Fath B, Bulas D, Bahadho-Singh R (eds) Fundamental and advanced fetal imaging. Wolters Kluwer Health, Philadelphia, pp 651–659
63.
Dimitraki M, Koutlaki N, Nikas I et al (2012) Fetal ovarian cysts. Our clinical experience over 16 cases and review of the literature. J Matern Fetal Neonatal Med 25:222–225PubMedCrossRef
64.
Ozcan HN, Balci S, Ekinci S et al (2015) Imaging findings of fetal-neonatal ovarian cysts complicated with ovarian torsion and autoamputation. AJR Am J Roentgenol 205:185–189PubMedCrossRef
Metadata
Title
Imaging of solid congenital abdominal masses: a review of the literature and practical approach to image interpretation
Author
Krista L. Birkemeier
Publication date
01-12-2020
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Radiology / Issue 13/2020
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI
https://doi.org/10.1007/s00247-020-04678-1

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