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Published in: Pediatric Radiology 2/2019

Open Access 01-02-2019 | Pictorial Essay

Imaging features of extranodal involvement in paediatric Hodgkin lymphoma

Authors: Suzanne Spijkers, Annemieke S. Littooij, Paul D. Humphries, Marnix G. E. H. Lam, Rutger A. J. Nievelstein

Published in: Pediatric Radiology | Issue 2/2019

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Abstract

Detecting extranodal disease in paediatric Hodgkin lymphoma is of great importance for both treatment and prognosis. Different imaging techniques can be used to identify these extranodal sites. This pictorial essay provides an overview of imaging features of extranodal disease manifestation in paediatric Hodgkin lymphoma.
Literature
2.
go back to reference Cheson BD, Fisher RI, Barrington SF et al (2014) Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification. J Clin Oncol 32:3059–3067CrossRefPubMedPubMedCentral Cheson BD, Fisher RI, Barrington SF et al (2014) Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification. J Clin Oncol 32:3059–3067CrossRefPubMedPubMedCentral
4.
go back to reference Stauss J, Franzius C, Pfluger T et al (2008) Guidelines for 18F-FDG PET and PET-CT imaging in paediatric oncology. Eur J Nucl Med Mol Imaging 35:1581–1588CrossRefPubMed Stauss J, Franzius C, Pfluger T et al (2008) Guidelines for 18F-FDG PET and PET-CT imaging in paediatric oncology. Eur J Nucl Med Mol Imaging 35:1581–1588CrossRefPubMed
5.
go back to reference Gatidis S, Schmidt H, Gücke B et al (2016) Comprehensive oncologic imaging in infants and preschool children with substantially reduced radiation exposure using combined simultaneous 18F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging. Investig Radiol 51:7–14CrossRef Gatidis S, Schmidt H, Gücke B et al (2016) Comprehensive oncologic imaging in infants and preschool children with substantially reduced radiation exposure using combined simultaneous 18F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging. Investig Radiol 51:7–14CrossRef
7.
go back to reference Albano D, Patti C, La Grutta L et al (2016) Comparison between whole-body MRI with diffusion-weighted imaging and PET/CT in staging newly diagnosed FDG-avid lymphomas. Eur J Radiol 85:313–318CrossRefPubMed Albano D, Patti C, La Grutta L et al (2016) Comparison between whole-body MRI with diffusion-weighted imaging and PET/CT in staging newly diagnosed FDG-avid lymphomas. Eur J Radiol 85:313–318CrossRefPubMed
8.
go back to reference Balbo-Mussetto A, Cirillo S, Bruna R et al (2016) Whole-body MRI with diffusion-weighted imaging: a valuable alternative to contrast-enhanced CT for initial staging of aggressive lymphoma. Clin Radiol 71:271–279CrossRefPubMed Balbo-Mussetto A, Cirillo S, Bruna R et al (2016) Whole-body MRI with diffusion-weighted imaging: a valuable alternative to contrast-enhanced CT for initial staging of aggressive lymphoma. Clin Radiol 71:271–279CrossRefPubMed
9.
go back to reference Littooij AS, Kwee TC, Barber I et al (2014) Whole-body MRI for initial staging of paediatric lymphoma: prospective comparison to an FDG-PET/CT-based reference standard. Eur Radiol 24:1153–1165CrossRefPubMed Littooij AS, Kwee TC, Barber I et al (2014) Whole-body MRI for initial staging of paediatric lymphoma: prospective comparison to an FDG-PET/CT-based reference standard. Eur Radiol 24:1153–1165CrossRefPubMed
10.
11.
go back to reference Regacini R, Puchnick A, Luisi FAV, Lederman HM (2018) Can diffusion-weighted whole-body MRI replace contrast-enhanced CT for initial staging of Hodgkin lymphoma in children and adolescents? Pediatr Radiol 48:638–647CrossRefPubMed Regacini R, Puchnick A, Luisi FAV, Lederman HM (2018) Can diffusion-weighted whole-body MRI replace contrast-enhanced CT for initial staging of Hodgkin lymphoma in children and adolescents? Pediatr Radiol 48:638–647CrossRefPubMed
12.
go back to reference Das J, Ray S, Sen S, Chandy M (2014) Extranodal involvement in lymphoma – a pictorial essay and retrospective analysis of 281 PET/CT studies. Asia Ocean J Nucl Med Biol 2:42–56PubMedPubMedCentral Das J, Ray S, Sen S, Chandy M (2014) Extranodal involvement in lymphoma – a pictorial essay and retrospective analysis of 281 PET/CT studies. Asia Ocean J Nucl Med Biol 2:42–56PubMedPubMedCentral
13.
go back to reference Paes FM, Kalkanis DG, Sideras PA, Serafini AN (2010) FDG PET/CT of extranodal involvement in non-Hodgkin lymphoma and Hodgkin disease. Radiographics 30:269–291CrossRefPubMed Paes FM, Kalkanis DG, Sideras PA, Serafini AN (2010) FDG PET/CT of extranodal involvement in non-Hodgkin lymphoma and Hodgkin disease. Radiographics 30:269–291CrossRefPubMed
14.
go back to reference Guermazi A, Brice P, de Kerviler EE et al (2001) Extranodal Hodgkin disease: spectrum of disease. Radiographics 21:161–179CrossRefPubMed Guermazi A, Brice P, de Kerviler EE et al (2001) Extranodal Hodgkin disease: spectrum of disease. Radiographics 21:161–179CrossRefPubMed
15.
go back to reference Ömür Ö, Baran Y, Oral A, Ceylan Y (2014) Fluorine-18 fluorodeoxyglucose PET-CT for extranodal staging of non-Hodgkin and Hodgkin lymphoma. Diagn Interv Radiol 20:185–192PubMedPubMedCentral Ömür Ö, Baran Y, Oral A, Ceylan Y (2014) Fluorine-18 fluorodeoxyglucose PET-CT for extranodal staging of non-Hodgkin and Hodgkin lymphoma. Diagn Interv Radiol 20:185–192PubMedPubMedCentral
16.
go back to reference Englund A, Glimelius I, Rostgaard K et al (2018) Hodgkin lymphoma in children, adolescents and young adults – a comparative study of clinical presentation and treatment outcome. Acta Oncol 57:276–282CrossRefPubMed Englund A, Glimelius I, Rostgaard K et al (2018) Hodgkin lymphoma in children, adolescents and young adults – a comparative study of clinical presentation and treatment outcome. Acta Oncol 57:276–282CrossRefPubMed
17.
go back to reference Balbo-Mussetto A, Saviolo C, Fornari A et al (2017) Whole body MRI with qualitative and quantitative analysis of DWI for assessment of bone marrow involvement in lymphoma. Radiol Med 122:623–632CrossRefPubMed Balbo-Mussetto A, Saviolo C, Fornari A et al (2017) Whole body MRI with qualitative and quantitative analysis of DWI for assessment of bone marrow involvement in lymphoma. Radiol Med 122:623–632CrossRefPubMed
18.
go back to reference Purz S, Mauz-Körholz C, Körholz D et al (2011) [18F]fluorodeoxyglucose positron emission tomography for detection of bone marrow involvement in children and adolescents with Hodgkin’s lymphoma. J Clin Oncol 29:3523–3528CrossRefPubMed Purz S, Mauz-Körholz C, Körholz D et al (2011) [18F]fluorodeoxyglucose positron emission tomography for detection of bone marrow involvement in children and adolescents with Hodgkin’s lymphoma. J Clin Oncol 29:3523–3528CrossRefPubMed
19.
go back to reference Smets AM, Deurloo EE, Slager TJE et al (2017) Whole-body magnetic resonance imaging for detection of skeletal metastases in children and young people with primary solid tumors - systematic review. Pediatr Radiol 48:241–252CrossRefPubMedPubMedCentral Smets AM, Deurloo EE, Slager TJE et al (2017) Whole-body magnetic resonance imaging for detection of skeletal metastases in children and young people with primary solid tumors - systematic review. Pediatr Radiol 48:241–252CrossRefPubMedPubMedCentral
20.
go back to reference Albano D, Patti C, Lagalla R et al (2017) Whole-body MRI, FDG-PET/CT, and bone marrow biopsy, for the assessment of bone marrow involvement in patients with newly diagnosed lymphoma. J Magn Reson Imaging 45:1082–1089CrossRefPubMed Albano D, Patti C, Lagalla R et al (2017) Whole-body MRI, FDG-PET/CT, and bone marrow biopsy, for the assessment of bone marrow involvement in patients with newly diagnosed lymphoma. J Magn Reson Imaging 45:1082–1089CrossRefPubMed
21.
go back to reference Rauscher I, Eiber M, Furst S et al (2014) PET/MR imaging in the detection and characterization of pulmonary lesions: technical and diagnostic evaluation in comparison to PET/CT. J Nucl Med 55:724–729CrossRefPubMed Rauscher I, Eiber M, Furst S et al (2014) PET/MR imaging in the detection and characterization of pulmonary lesions: technical and diagnostic evaluation in comparison to PET/CT. J Nucl Med 55:724–729CrossRefPubMed
22.
go back to reference Ilica AT, Kocacelebi K, Savas R, Ayan A (2011) Imaging of extranodal lymphoma with PET/CT. Clin Nucl Med 36:e127–e138CrossRefPubMed Ilica AT, Kocacelebi K, Savas R, Ayan A (2011) Imaging of extranodal lymphoma with PET/CT. Clin Nucl Med 36:e127–e138CrossRefPubMed
23.
go back to reference Kluge R, Kurch L, Georgi T, Metzger M (2017) Current role of FDG-PET in pediatric Hodgkin’s lymphoma. Semin Nucl Med 47:242–257CrossRefPubMed Kluge R, Kurch L, Georgi T, Metzger M (2017) Current role of FDG-PET in pediatric Hodgkin’s lymphoma. Semin Nucl Med 47:242–257CrossRefPubMed
24.
go back to reference Adams HJA, de Klerk JM, Fijnheer R et al (2015) Variety in bone marrow 18F-FDG uptake in Hodgkin lymphoma patients without lymphomatous bone marrow involvement. Nucl Med Commun 37:23–29 Adams HJA, de Klerk JM, Fijnheer R et al (2015) Variety in bone marrow 18F-FDG uptake in Hodgkin lymphoma patients without lymphomatous bone marrow involvement. Nucl Med Commun 37:23–29
25.
go back to reference Bigenwald C, Galimard JE, Quero L et al (2017) Hodgkin lymphoma in adolescent and young adults: insights from an adult tertiary single-center cohort of 349 patients. Oncotarget 8:80073–80082CrossRefPubMedPubMedCentral Bigenwald C, Galimard JE, Quero L et al (2017) Hodgkin lymphoma in adolescent and young adults: insights from an adult tertiary single-center cohort of 349 patients. Oncotarget 8:80073–80082CrossRefPubMedPubMedCentral
26.
go back to reference Even-Sapir E, Lievshitz G, Perry C et al (2007) Fluorine-18 fluorodeoxyglucose PET/CT patterns of extranodal involvement in patients with non-Hodgkin lymphoma and Hodgkin’s disease. Radiol Clin N Am 45:697–709CrossRefPubMed Even-Sapir E, Lievshitz G, Perry C et al (2007) Fluorine-18 fluorodeoxyglucose PET/CT patterns of extranodal involvement in patients with non-Hodgkin lymphoma and Hodgkin’s disease. Radiol Clin N Am 45:697–709CrossRefPubMed
27.
go back to reference Munker R, Stengel A, Stäbler A et al (1995) Diagnostic accuracy of ultrasound and computed tomography in the staging of Hodgkin’s disease. Verification by laparotomy in 100 cases. Cancer 76:1460–1466CrossRefPubMed Munker R, Stengel A, Stäbler A et al (1995) Diagnostic accuracy of ultrasound and computed tomography in the staging of Hodgkin’s disease. Verification by laparotomy in 100 cases. Cancer 76:1460–1466CrossRefPubMed
28.
go back to reference Keup CP, Ratnaraj F, Chopra PR et al (2013) Magnetic resonance imaging of the pediatric liver: Benign and malignant masses. Magn Reson Imaging Clin N Am 21:645–667CrossRefPubMed Keup CP, Ratnaraj F, Chopra PR et al (2013) Magnetic resonance imaging of the pediatric liver: Benign and malignant masses. Magn Reson Imaging Clin N Am 21:645–667CrossRefPubMed
29.
go back to reference Riola-Parada C, García-Cañamaque L, Pérez-Dueñas V et al (2016) Simultaneous PET/MRI vs. PET/CT in oncology. A systematic review. Rev Esp Med Nucl Imagen Mol 35:306–312 Riola-Parada C, García-Cañamaque L, Pérez-Dueñas V et al (2016) Simultaneous PET/MRI vs. PET/CT in oncology. A systematic review. Rev Esp Med Nucl Imagen Mol 35:306–312
30.
go back to reference Schäfer JF, Gatidis S, Schmidt H et al (2014) Simultaneous whole-body PET/MR imaging in comparison to PET/CT in pediatric oncology: initial results. Radiology 273:220–231CrossRefPubMed Schäfer JF, Gatidis S, Schmidt H et al (2014) Simultaneous whole-body PET/MR imaging in comparison to PET/CT in pediatric oncology: initial results. Radiology 273:220–231CrossRefPubMed
31.
go back to reference Urasinski T, Kamienska E, Gawlikowska-Sroka A et al (2010) Pediatric pulmonary Hodgkin lymphoma: analysis of 10 years data from a single center. Eur J Med Res 15(Suppl2):206–210PubMedPubMedCentral Urasinski T, Kamienska E, Gawlikowska-Sroka A et al (2010) Pediatric pulmonary Hodgkin lymphoma: analysis of 10 years data from a single center. Eur J Med Res 15(Suppl2):206–210PubMedPubMedCentral
32.
go back to reference Maturen KE, Blane CE, Strouse PJ, Fitzgerald JT (2004) Pulmonary involvement in pediatric lymphoma. Pediatr Radiol 34:120–124CrossRefPubMed Maturen KE, Blane CE, Strouse PJ, Fitzgerald JT (2004) Pulmonary involvement in pediatric lymphoma. Pediatr Radiol 34:120–124CrossRefPubMed
33.
go back to reference Dewes P, Frellesen C, Al-Butmeh F et al (2016) Comparative evaluation of non-contrast CAIPIRINHA-VIBE 3T-MRI and multidetector CT for detection of pulmonary nodules: in vivo evaluation of diagnostic accuracy and image quality. Eur J Radiol 85:193–198CrossRefPubMed Dewes P, Frellesen C, Al-Butmeh F et al (2016) Comparative evaluation of non-contrast CAIPIRINHA-VIBE 3T-MRI and multidetector CT for detection of pulmonary nodules: in vivo evaluation of diagnostic accuracy and image quality. Eur J Radiol 85:193–198CrossRefPubMed
34.
go back to reference Hunter BD, Dhakal S, Voci S et al (2014) Pleural effusions in patients with Hodgkin lymphoma: clinical predictors and associations with outcome. Leuk Lymphoma 55:1822–1826CrossRefPubMed Hunter BD, Dhakal S, Voci S et al (2014) Pleural effusions in patients with Hodgkin lymphoma: clinical predictors and associations with outcome. Leuk Lymphoma 55:1822–1826CrossRefPubMed
35.
go back to reference Toaff JS, Metser U, Gottfried M et al (2005) Differentiation between malignant and benign pleural effusion in patients with extra-pleural primary malignancies: assessment with positron emission tomography-computed tomography. Investig Radiol 40:204–209CrossRef Toaff JS, Metser U, Gottfried M et al (2005) Differentiation between malignant and benign pleural effusion in patients with extra-pleural primary malignancies: assessment with positron emission tomography-computed tomography. Investig Radiol 40:204–209CrossRef
36.
go back to reference Gill RR, Patz S, Muradyan I, Seethamraju RT (2015) Novel MR imaging applications for pleural evaluation. Magn Reson Imaging Clin N Am 23:179–195CrossRefPubMed Gill RR, Patz S, Muradyan I, Seethamraju RT (2015) Novel MR imaging applications for pleural evaluation. Magn Reson Imaging Clin N Am 23:179–195CrossRefPubMed
37.
go back to reference Rueffer U, Sieber M, Stemberg M et al (2003) Spleen involvement in Hodgkin’s lymphoma: assessment and risk profile. Ann Hematol 82:390–396CrossRefPubMed Rueffer U, Sieber M, Stemberg M et al (2003) Spleen involvement in Hodgkin’s lymphoma: assessment and risk profile. Ann Hematol 82:390–396CrossRefPubMed
38.
39.
go back to reference Liu Y (2009) Clinical significance of diffusely increased splenic uptake on FDG-PET. Nucl Med Commun 30:763–769CrossRefPubMed Liu Y (2009) Clinical significance of diffusely increased splenic uptake on FDG-PET. Nucl Med Commun 30:763–769CrossRefPubMed
40.
go back to reference Littooij AS, Kwee TC, Barber I et al (2015) Accuracy of whole-body MRI in the assessment of splenic involvement in lymphoma. Acta Radiol 57:1–10 Littooij AS, Kwee TC, Barber I et al (2015) Accuracy of whole-body MRI in the assessment of splenic involvement in lymphoma. Acta Radiol 57:1–10
41.
go back to reference Palas J, Matos AP, Ramalho M (2013) The spleen revisited: an overview on magnetic resonance imaging. Radiol Res Pract 2013:1–15CrossRef Palas J, Matos AP, Ramalho M (2013) The spleen revisited: an overview on magnetic resonance imaging. Radiol Res Pract 2013:1–15CrossRef
42.
go back to reference Punwani S, Cheung KK, Skipper N et al (2013) Dynamic contrast-enhanced MRI improves accuracy for detecting focal splenic involvement in children and adolescents with Hodgkin disease. Pediatr Radiol 43:941–949CrossRefPubMed Punwani S, Cheung KK, Skipper N et al (2013) Dynamic contrast-enhanced MRI improves accuracy for detecting focal splenic involvement in children and adolescents with Hodgkin disease. Pediatr Radiol 43:941–949CrossRefPubMed
43.
go back to reference Chepuri NB, Strouse PJ, Yanik GA (2003) CT of renal lymphoma in children. Am J Neuroradiol 180:429–431 Chepuri NB, Strouse PJ, Yanik GA (2003) CT of renal lymphoma in children. Am J Neuroradiol 180:429–431
44.
go back to reference Buchmann I, Wandt H, Wahl A, Reske SN (2003) FDG PET for imaging pericardial manifestations of Hodgkin lymphoma. Clin Nucl Med 28:760–761CrossRefPubMed Buchmann I, Wandt H, Wahl A, Reske SN (2003) FDG PET for imaging pericardial manifestations of Hodgkin lymphoma. Clin Nucl Med 28:760–761CrossRefPubMed
Metadata
Title
Imaging features of extranodal involvement in paediatric Hodgkin lymphoma
Authors
Suzanne Spijkers
Annemieke S. Littooij
Paul D. Humphries
Marnix G. E. H. Lam
Rutger A. J. Nievelstein
Publication date
01-02-2019
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Radiology / Issue 2/2019
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI
https://doi.org/10.1007/s00247-018-4280-z

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