Top

Published in:

01-10-2016 | Case Report

Imaging findings in a child with calcineurin inhibitor-induced pain syndrome after bone marrow transplant for beta thalassemia major

Authors: Rama S. Ayyala, Staci D. Arnold, Monica Bhatia, Jahannaz Dastgir

Published in: Pediatric Radiology | Issue 11/2016

Abstract

Calcineurin inhibitor-induced pain syndrome is an entity recognized in patients on immunosuppressive therapy after transplantation. Diagnosis is characterized by onset of pain beginning in the setting of an elevated calcineurin-inhibitor trough level. Reducing the medication dose relieves symptoms. Imaging findings can be nonspecific, including bone marrow edema and periosteal reaction. We present the unique case of calcineurin inhibitor-induced pain syndrome in a child and review the imaging findings.

Lucas VP, Ponge TD, Plougastel-Lucas ML et al (1991) Musculoskeletal pain in renal-transplant recipients. N Engl J Med 325:1449–1450CrossRefPubMed

Grotz WH, Breitenfeldt MK, Braune SW et al (2001) Calcineurin-inhibitor induced pain syndrome (CIPS): a severe disabling complication after organ transplantation. Transpl Int 14:16–23

Chapin RW, Chua E, Simmons J et al (2013) Case report: imaging features in a renal transplant patient with calcineurin inhibitor-induced pain syndrome (CIPS). Skeletal Radiol 42:1311–1315CrossRefPubMed

Gurin L, Gohh R, Evangelista P (2012) Pain syndrome with stress fractures in transplanted patients treated with calcineurin inhibitors. Clin Kidney J 5:13–16CrossRefPubMedPubMedCentral

Nishikawa T, Okamoto Y, Tanabe T et al (2009) Calcineurin-inhibitor-induced pain syndrome after a second allogeneic bone marrow transplantation for a child with aplastic anemia. Pediatr Transplant 13:641–644

Lavoratore SR, Navarro OM, Grunebaum E et al (2009) Cyclosporine-induced pain syndrome in a child undergoing hematopoietic stem cell transplant. Ann Pharmacother 43:767–771CrossRefPubMed

Vande Berg BC, Malghem J, Goffin EJ et al (1994) Transient epiphyseal lesions in renal transplant recipients: presumed insufficiency stress fractures. Radiology 191:403–407CrossRefPubMed

Tillmann FP, Jager M, Blondin D et al (2007) Intravenous iloprost: a new therapeutic option for patients with post-transplant distal limb syndrome (PTDLS). Am J Transplant 7:667–671CrossRefPubMed

Title: Imaging findings in a child with calcineurin inhibitor-induced pain syndrome after bone marrow transplant for beta thalassemia major
Authors: Rama S. Ayyala
Staci D. Arnold
Monica Bhatia
Jahannaz Dastgir
Publication date: 01-10-2016
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Radiology / Issue 11/2016
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-016-3644-5

At a glance: The STEP trials

Springer Medicine

Imaging findings in a child with calcineurin inhibitor-induced pain syndrome after bone marrow transplant for beta thalassemia major

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 11/2016

Image quality and dose differences caused by vendor-specific image processing of neonatal radiographs

The changing face of complicated infantile hemangioma treatment

Hermes

Imaging findings and management of diaphragmatic mesothelial cysts in children

Residual intravesical iodinated contrast: a potential cause of false-negative reflux study at contrast-enhanced voiding urosonography

Variables decreasing tip movement of peripherally inserted central catheters in pediatric patients