Skip to main content
Top
Published in: Pediatric Radiology 13/2015

01-12-2015 | Review

Risks to the fetus from diagnostic imaging during pregnancy: review and proposal of a clinical protocol

Authors: Mafalda Gomes, Alexandra Matias, Filipe Macedo

Published in: Pediatric Radiology | Issue 13/2015

Login to get access

Abstract

Every day, medical practitioners face the dilemma of exposing pregnant or possibly pregnant patients to radiation from diagnostic examinations. Both doctors and patients often have questions about the risks of radiation. The most vulnerable period is between the 8th and 15th weeks of gestation. Deterministic effects like pregnancy loss, congenital malformations, growth retardation and neurobehavioral abnormalities have threshold doses above 100–200 mGy. The risk is considered negligible at 50 mGy and in reality no diagnostic examination exceeds this limit. The risk of carcinogenesis is slightly higher than in the general population. Intravenous iodinated contrast is discouraged, except in highly selected patients. Considering all the possible noxious effects of radiation exposure, measures to diminish radiation are essential and affect the fetal outcome. Nonionizing procedures should be considered whenever possible and every radiology center should have its own data analysis on fetal radiation exposure. In this review, we analyze existing literature on fetal risks due to radiation exposure, producing a clinical protocol to guide safe radiation use in a clinical setting.
Literature
1.
go back to reference El-Khoury GY, Madsen MT, Blake ME et al (2003) A new pregnancy policy for a new era. AJR Am J Roentgenol 181:335–340CrossRefPubMed El-Khoury GY, Madsen MT, Blake ME et al (2003) A new pregnancy policy for a new era. AJR Am J Roentgenol 181:335–340CrossRefPubMed
2.
3.
go back to reference Wang PI, Chong ST, Kielar AZ et al (2012) Imaging of pregnant and lactating patients: part 1, evidence-based review and recommendations. AJR Am J Roentgenol 198:778–784CrossRefPubMed Wang PI, Chong ST, Kielar AZ et al (2012) Imaging of pregnant and lactating patients: part 1, evidence-based review and recommendations. AJR Am J Roentgenol 198:778–784CrossRefPubMed
4.
go back to reference Goodman TR, Amurao M (2012) Medical imaging radiation safety for the female patient: rationale and implementation. Radiographics 32:1829–1837CrossRefPubMed Goodman TR, Amurao M (2012) Medical imaging radiation safety for the female patient: rationale and implementation. Radiographics 32:1829–1837CrossRefPubMed
5.
go back to reference Ursprung WM, Howe JW, Yochum TR et al (2006) Plain film radiography, pregnancy, and therapeutic abortion revisited. J Mani Physiol Ther 29:83–87CrossRef Ursprung WM, Howe JW, Yochum TR et al (2006) Plain film radiography, pregnancy, and therapeutic abortion revisited. J Mani Physiol Ther 29:83–87CrossRef
6.
go back to reference De Wilde JP, Rivers AW, Price DL (2005) A review of the current use of magnetic resonance imaging in pregnancy and safety implications for the fetus. Prog Biophys Mol Biol 87:335–353CrossRefPubMed De Wilde JP, Rivers AW, Price DL (2005) A review of the current use of magnetic resonance imaging in pregnancy and safety implications for the fetus. Prog Biophys Mol Biol 87:335–353CrossRefPubMed
7.
go back to reference Shin DS, Poder L, Courtier J et al (2011) CT and MRI of early intrauterine pregnancy. AJR Am J Roentgenol 196:325–330CrossRefPubMed Shin DS, Poder L, Courtier J et al (2011) CT and MRI of early intrauterine pregnancy. AJR Am J Roentgenol 196:325–330CrossRefPubMed
8.
go back to reference Colletti PM, Lee KH, Elkayam U (2013) Cardiovascular imaging of the pregnant patient. AJR Am J Roentgenol 200:515–521CrossRefPubMed Colletti PM, Lee KH, Elkayam U (2013) Cardiovascular imaging of the pregnant patient. AJR Am J Roentgenol 200:515–521CrossRefPubMed
9.
go back to reference Toppenberg KS, Hill DA, Miller DP (1999) Safety of radiographic imaging during pregnancy. Am Fam Physician 59:1813–1818, 1820 PubMed Toppenberg KS, Hill DA, Miller DP (1999) Safety of radiographic imaging during pregnancy. Am Fam Physician 59:1813–1818, 1820 PubMed
10.
go back to reference Jaffe TA, Yoshizumi TT, Toncheva GI et al (2008) Early first-trimester fetal radiation dose estimation in 16-MDCT without and with automated tube current modulation. AJR Am J Roentgenol 190:860–864CrossRefPubMed Jaffe TA, Yoshizumi TT, Toncheva GI et al (2008) Early first-trimester fetal radiation dose estimation in 16-MDCT without and with automated tube current modulation. AJR Am J Roentgenol 190:860–864CrossRefPubMed
11.
go back to reference Williams PM, Fletcher S (2010) Health effects of prenatal radiation exposure. Am Fam Physician 82:488–493PubMed Williams PM, Fletcher S (2010) Health effects of prenatal radiation exposure. Am Fam Physician 82:488–493PubMed
12.
go back to reference Wood JW, Johnson KG, Omori Y (1967) In utero exposure to the Hiroshima atomic bomb. An evaluation of head size and mental retardation: twenty years later. Pediatrics 39:385–392PubMed Wood JW, Johnson KG, Omori Y (1967) In utero exposure to the Hiroshima atomic bomb. An evaluation of head size and mental retardation: twenty years later. Pediatrics 39:385–392PubMed
13.
go back to reference De Santis M, Di Gianantonio E, Straface G et al (2005) Ionizing radiations in pregnancy and teratogenesis: a review of literature. Reprod Toxicol 20:323–329CrossRefPubMed De Santis M, Di Gianantonio E, Straface G et al (2005) Ionizing radiations in pregnancy and teratogenesis: a review of literature. Reprod Toxicol 20:323–329CrossRefPubMed
14.
go back to reference Strzelczyk J, Damilakis J, Marx MV et al (2007) Facts and controversies about radiation exposure, part 2: low-level exposures and cancer risk. J Am Coll Radiol 4:32–39CrossRefPubMed Strzelczyk J, Damilakis J, Marx MV et al (2007) Facts and controversies about radiation exposure, part 2: low-level exposures and cancer risk. J Am Coll Radiol 4:32–39CrossRefPubMed
15.
go back to reference Donnelly EH, Smith JM, Farfán EB et al (2011) Prenatal radiation exposure: background material for counseling pregnant patients following exposure to radiation. Disaster Med Public Health Prep 5:62–68CrossRefPubMed Donnelly EH, Smith JM, Farfán EB et al (2011) Prenatal radiation exposure: background material for counseling pregnant patients following exposure to radiation. Disaster Med Public Health Prep 5:62–68CrossRefPubMed
17.
go back to reference Ray JG, Schull MJ, Urquia ML et al (2010) Major radiodiagnostic imaging in pregnancy and the risk of childhood malignancy: a population-based cohort study in Ontario. PLoS Med 7, e1000337PubMedCentralCrossRefPubMed Ray JG, Schull MJ, Urquia ML et al (2010) Major radiodiagnostic imaging in pregnancy and the risk of childhood malignancy: a population-based cohort study in Ontario. PLoS Med 7, e1000337PubMedCentralCrossRefPubMed
18.
go back to reference Parmaksiz A, Atac GK, Bulgurlu F et al (2013) Unintentional irradiation of conceptus by diagnostic imaging examinations in Turkey. Radiat Prot Dosim 162:322–328CrossRef Parmaksiz A, Atac GK, Bulgurlu F et al (2013) Unintentional irradiation of conceptus by diagnostic imaging examinations in Turkey. Radiat Prot Dosim 162:322–328CrossRef
19.
go back to reference Gu J, Xu XG, Caracappa PF et al (2013) Fetal doses to pregnant patients from CT with tube current modulation calculated using Monte Carlo simulations and realistic phantoms. Radiat Prot Dosim 155:64–72CrossRef Gu J, Xu XG, Caracappa PF et al (2013) Fetal doses to pregnant patients from CT with tube current modulation calculated using Monte Carlo simulations and realistic phantoms. Radiat Prot Dosim 155:64–72CrossRef
20.
go back to reference Lowe SA (2004) Diagnostic radiography in pregnancy: risks and reality. Aust N Z J Obstet Gynaecol 44:191–196CrossRefPubMed Lowe SA (2004) Diagnostic radiography in pregnancy: risks and reality. Aust N Z J Obstet Gynaecol 44:191–196CrossRefPubMed
21.
go back to reference Lockwood D, Einstein D, Davros W (2007) Diagnostic imaging: radiation dose and patients’ concerns. Cleve Clin J Med 73:583–586CrossRef Lockwood D, Einstein D, Davros W (2007) Diagnostic imaging: radiation dose and patients’ concerns. Cleve Clin J Med 73:583–586CrossRef
22.
23.
go back to reference Pahade JK, Litmanovich D, Pedrosa I et al (2009) Quality initiatives: imaging pregnant patients with suspected pulmonary embolism: what the radiologist needs to know. Radiographics 29:639–654CrossRefPubMed Pahade JK, Litmanovich D, Pedrosa I et al (2009) Quality initiatives: imaging pregnant patients with suspected pulmonary embolism: what the radiologist needs to know. Radiographics 29:639–654CrossRefPubMed
24.
go back to reference Cogley JR, Ghobrial PM, Chandrasekaran B et al (2012) Pulmonary embolism evaluation in the pregnant patient: a review of current imaging approaches. Semin Ultrasound CT MR 33:11–17CrossRefPubMed Cogley JR, Ghobrial PM, Chandrasekaran B et al (2012) Pulmonary embolism evaluation in the pregnant patient: a review of current imaging approaches. Semin Ultrasound CT MR 33:11–17CrossRefPubMed
25.
go back to reference McCollough CH, Schueler BA, Atwell TD et al (2007) Radiation exposure and pregnancy: when should we be concerned? Radiographics 27:909–917CrossRefPubMed McCollough CH, Schueler BA, Atwell TD et al (2007) Radiation exposure and pregnancy: when should we be concerned? Radiographics 27:909–917CrossRefPubMed
26.
go back to reference Patel SJ, Reede DL, Katz DS et al (2007) Imaging the pregnant patient for nonobstetric conditions: algorithms and radiation dose considerations. Radiographics 27:1705–1722CrossRefPubMed Patel SJ, Reede DL, Katz DS et al (2007) Imaging the pregnant patient for nonobstetric conditions: algorithms and radiation dose considerations. Radiographics 27:1705–1722CrossRefPubMed
27.
28.
go back to reference Sadro C, Bernstein MP, Kanal KM (2012) Imaging of trauma: Part 2, Abdominal trauma and pregnancy–a radiologist’s guide to doing what is best for the mother and baby. AJR Am J Roentgenol 199:1207–1219CrossRefPubMed Sadro C, Bernstein MP, Kanal KM (2012) Imaging of trauma: Part 2, Abdominal trauma and pregnancy–a radiologist’s guide to doing what is best for the mother and baby. AJR Am J Roentgenol 199:1207–1219CrossRefPubMed
29.
go back to reference Gu J, Bednarz B, Caracappa PF et al (2009) The development, validation and application of a multi-detector CT (MDCT) scanner model for assessing organ doses to the pregnant patient and the fetus using Monte Carlo simulations. Phys Med Biol 54:2699–2717PubMedCentralCrossRefPubMed Gu J, Bednarz B, Caracappa PF et al (2009) The development, validation and application of a multi-detector CT (MDCT) scanner model for assessing organ doses to the pregnant patient and the fetus using Monte Carlo simulations. Phys Med Biol 54:2699–2717PubMedCentralCrossRefPubMed
30.
go back to reference Duran-Mendicuti A, Sodickson A (2011) Imaging evaluation of the pregnant patient with suspected pulmonary embolism. Int J Obstet Anesth 20:51–59CrossRefPubMed Duran-Mendicuti A, Sodickson A (2011) Imaging evaluation of the pregnant patient with suspected pulmonary embolism. Int J Obstet Anesth 20:51–59CrossRefPubMed
31.
go back to reference Damilakis J, Perisinakis K, Prassopoulos P et al (2003) Conceptus radiation dose and risk from chest screen-film radiography. Eur Radiol 13:406–412 Damilakis J, Perisinakis K, Prassopoulos P et al (2003) Conceptus radiation dose and risk from chest screen-film radiography. Eur Radiol 13:406–412
32.
go back to reference Shetty MK (2010) Abdominal computed tomography during pregnancy: a review of indications and fetal radiation exposure issues. Semin Ultrasound CT MR 31:3–7CrossRefPubMed Shetty MK (2010) Abdominal computed tomography during pregnancy: a review of indications and fetal radiation exposure issues. Semin Ultrasound CT MR 31:3–7CrossRefPubMed
33.
go back to reference Helmrot E, Pettersson H, Sandborg M et al (2007) Estimation of dose to the unborn child at diagnostic X-ray examinations based on data registered in RIS/PACS. Eur Radiol 17:205–209 Helmrot E, Pettersson H, Sandborg M et al (2007) Estimation of dose to the unborn child at diagnostic X-ray examinations based on data registered in RIS/PACS. Eur Radiol 17:205–209
34.
go back to reference Chatterson LC, Leswick DA, Fladeland DA et al (2011) Lead versus bismuth-antimony shield for fetal dose reduction at different gestational ages at CT pulmonary angiography. Radiology 260:560–567CrossRefPubMed Chatterson LC, Leswick DA, Fladeland DA et al (2011) Lead versus bismuth-antimony shield for fetal dose reduction at different gestational ages at CT pulmonary angiography. Radiology 260:560–567CrossRefPubMed
35.
go back to reference Wieseler KM, Bhargava P, Kanal KM et al (2010) Imaging in pregnant patients: examination appropriateness. Radiographics 30:1215–1229CrossRefPubMed Wieseler KM, Bhargava P, Kanal KM et al (2010) Imaging in pregnant patients: examination appropriateness. Radiographics 30:1215–1229CrossRefPubMed
36.
go back to reference Hurwitz LM, Yoshizumi T, Reiman RE et al (2006) Radiation dose to the fetus from body MDCT during early gestation. AJR Am J Roentgenol 186:871–876 Hurwitz LM, Yoshizumi T, Reiman RE et al (2006) Radiation dose to the fetus from body MDCT during early gestation. AJR Am J Roentgenol 186:871–876
37.
go back to reference Parry RA, Glaze SA, Archer BR (1999) The AAPM/RSNA physics tutorial for residents. Typical patient radiation doses in diagnostic radiology. Radiographics 19:1289–1302CrossRefPubMed Parry RA, Glaze SA, Archer BR (1999) The AAPM/RSNA physics tutorial for residents. Typical patient radiation doses in diagnostic radiology. Radiographics 19:1289–1302CrossRefPubMed
38.
40.
go back to reference Hui CM, MacGregor JH, Tien HC et al (2009) Radiation dose from initial trauma assessment and resuscitation: review of the literature. Can J Surg 52:147–152PubMedCentralPubMed Hui CM, MacGregor JH, Tien HC et al (2009) Radiation dose from initial trauma assessment and resuscitation: review of the literature. Can J Surg 52:147–152PubMedCentralPubMed
41.
go back to reference Brent RL (2009) Saving lives and changing family histories: appropriate counseling of pregnant women and men and women of reproductive age, concerning the risk of diagnostic radiation exposures during and before pregnancy. Am J Obstet Gynecol 200:4–24CrossRefPubMed Brent RL (2009) Saving lives and changing family histories: appropriate counseling of pregnant women and men and women of reproductive age, concerning the risk of diagnostic radiation exposures during and before pregnancy. Am J Obstet Gynecol 200:4–24CrossRefPubMed
42.
go back to reference Moradi M (2013) Pulmonary thromboembolism in pregnancy: diagnostic imaging and related consideration. J Res Med Sci 18:255–259PubMedCentralPubMed Moradi M (2013) Pulmonary thromboembolism in pregnancy: diagnostic imaging and related consideration. J Res Med Sci 18:255–259PubMedCentralPubMed
43.
go back to reference Puri A, Khadem P, Ahmed S et al (2012) Imaging of trauma in a pregnant patient. Semin Ultrasound CT MR 33:37–45CrossRefPubMed Puri A, Khadem P, Ahmed S et al (2012) Imaging of trauma in a pregnant patient. Semin Ultrasound CT MR 33:37–45CrossRefPubMed
44.
go back to reference Sadro CT, Dubinsky TJ (2013) CT in pregnancy: risks and benefits. Appl Radiol 42:6–16 Sadro CT, Dubinsky TJ (2013) CT in pregnancy: risks and benefits. Appl Radiol 42:6–16
45.
go back to reference Miller DL, Balter S, Schueler BA et al (2010) Clinical radiation management for fluoroscopically guided interventional procedures. Radiology 257:321–332CrossRefPubMed Miller DL, Balter S, Schueler BA et al (2010) Clinical radiation management for fluoroscopically guided interventional procedures. Radiology 257:321–332CrossRefPubMed
46.
go back to reference Goldberg-Stein SA, Liu B, Hahn PF et al (2012) Radiation dose management: part 2, estimating fetal radiation risk from CT during pregnancy. AJR Am J Roentgenol 198:W352–W356CrossRefPubMed Goldberg-Stein SA, Liu B, Hahn PF et al (2012) Radiation dose management: part 2, estimating fetal radiation risk from CT during pregnancy. AJR Am J Roentgenol 198:W352–W356CrossRefPubMed
47.
go back to reference Gilet AG, Dunkin JM, Fernandez TJ et al (2011) Fetal radiation dose during gestation estimated on an anthropomorphic phantom for three generations of CT scanners. AJR Am J Roentgenol 196:1133–1137CrossRefPubMed Gilet AG, Dunkin JM, Fernandez TJ et al (2011) Fetal radiation dose during gestation estimated on an anthropomorphic phantom for three generations of CT scanners. AJR Am J Roentgenol 196:1133–1137CrossRefPubMed
48.
go back to reference Samara ET, Stratakis J, Enele Melono JM et al (2009) Therapeutic ERCP and pregnancy: is the radiation risk for the conceptus trivial? Gastrointest Endosc 69:824–831CrossRefPubMed Samara ET, Stratakis J, Enele Melono JM et al (2009) Therapeutic ERCP and pregnancy: is the radiation risk for the conceptus trivial? Gastrointest Endosc 69:824–831CrossRefPubMed
49.
go back to reference Dauer LT, Thornton RH, Miller DL et al (2012) Radiation management for interventions using fluoroscopic or computed tomographic guidance during pregnancy: a joint guideline of the Society of Interventional Radiology and the Cardiovascular and Interventional Radiological Society of Europe with Endorsement by the Canadian Interventional Radiology Association. J Vasc Interv Radiol 23:19–32CrossRefPubMed Dauer LT, Thornton RH, Miller DL et al (2012) Radiation management for interventions using fluoroscopic or computed tomographic guidance during pregnancy: a joint guideline of the Society of Interventional Radiology and the Cardiovascular and Interventional Radiological Society of Europe with Endorsement by the Canadian Interventional Radiology Association. J Vasc Interv Radiol 23:19–32CrossRefPubMed
50.
go back to reference Masselli G, Derme M, Laghi F et al (2013) Imaging of stone disease in pregnancy. Abdom Imaging 38:1409–1414CrossRefPubMed Masselli G, Derme M, Laghi F et al (2013) Imaging of stone disease in pregnancy. Abdom Imaging 38:1409–1414CrossRefPubMed
51.
go back to reference Pearl J, Price R, Richardson W et al (2011) Guidelines for diagnosis, treatment, and use of laparoscopy for surgical problems during pregnancy. Surg Endosc 25:3479–3492CrossRefPubMed Pearl J, Price R, Richardson W et al (2011) Guidelines for diagnosis, treatment, and use of laparoscopy for surgical problems during pregnancy. Surg Endosc 25:3479–3492CrossRefPubMed
52.
go back to reference Goldman SM, Wagner LK (1996) Radiologic management of abdominal trauma in pregnancy. AJR Am J Roentgenol 166:763–767CrossRefPubMed Goldman SM, Wagner LK (1996) Radiologic management of abdominal trauma in pregnancy. AJR Am J Roentgenol 166:763–767CrossRefPubMed
53.
go back to reference Chen MM, Coakley FV, Kaimal A et al (2008) Guidelines for computed tomography and magnetic resonance imaging use during pregnancy and lactation. Obstet Gynecol 112:333–340CrossRefPubMed Chen MM, Coakley FV, Kaimal A et al (2008) Guidelines for computed tomography and magnetic resonance imaging use during pregnancy and lactation. Obstet Gynecol 112:333–340CrossRefPubMed
54.
56.
go back to reference Goldberg-Stein S, Liu B, Hahn PF et al (2011) Body CT during pregnancy: utilization trends, examination indications, and fetal radiation doses. AJR Am J Roentgenol 196:146–151CrossRefPubMed Goldberg-Stein S, Liu B, Hahn PF et al (2011) Body CT during pregnancy: utilization trends, examination indications, and fetal radiation doses. AJR Am J Roentgenol 196:146–151CrossRefPubMed
57.
go back to reference Scarsbrook AF, Evans AL, Owen AR et al (2006) Diagnosis of suspected venous thromboembolic disease in pregnancy. Clin Radiol 61:1–12CrossRefPubMed Scarsbrook AF, Evans AL, Owen AR et al (2006) Diagnosis of suspected venous thromboembolic disease in pregnancy. Clin Radiol 61:1–12CrossRefPubMed
58.
go back to reference Austin LM, Frush DP (2011) Compendium of national guidelines for imaging the pregnant patient. AJR Am J Roentgenol 197:W737–W746CrossRefPubMed Austin LM, Frush DP (2011) Compendium of national guidelines for imaging the pregnant patient. AJR Am J Roentgenol 197:W737–W746CrossRefPubMed
59.
go back to reference Choi JS, Han JY, Ahn HK et al (2013) Foetal and neonatal outcomes in first-trimester pregnant women exposed to abdominal or lumbar radiodiagnostic procedures without administration of radionucleotides. Intern Med J 43:513–518CrossRefPubMed Choi JS, Han JY, Ahn HK et al (2013) Foetal and neonatal outcomes in first-trimester pregnant women exposed to abdominal or lumbar radiodiagnostic procedures without administration of radionucleotides. Intern Med J 43:513–518CrossRefPubMed
60.
go back to reference Whitt CK (2010) Protecting pregnant women. Radiol Technol 81:387–389PubMed Whitt CK (2010) Protecting pregnant women. Radiol Technol 81:387–389PubMed
61.
go back to reference Thabet A, Kalva SP, Liu B et al (2012) Interventional radiology in pregnancy complications: indications, technique, and methods for minimizing radiation exposure. Radiographics 32:255–274CrossRefPubMed Thabet A, Kalva SP, Liu B et al (2012) Interventional radiology in pregnancy complications: indications, technique, and methods for minimizing radiation exposure. Radiographics 32:255–274CrossRefPubMed
62.
go back to reference Schuck AD (2008) A patient might be pregnant: now what? Radiol Technol 79:270–272PubMed Schuck AD (2008) A patient might be pregnant: now what? Radiol Technol 79:270–272PubMed
63.
go back to reference Baron TH, Schueler BA (2009) Pregnancy and radiation exposure during therapeutic ERCP: time to put the baby to bed? Gastrointest Endosc 69:832–834CrossRefPubMed Baron TH, Schueler BA (2009) Pregnancy and radiation exposure during therapeutic ERCP: time to put the baby to bed? Gastrointest Endosc 69:832–834CrossRefPubMed
64.
go back to reference Applegate K (2007) Pregnancy screening of adolescents and women before radiologic testing: does radiology need a national guideline? J Am Coll Radiol 4:533–536CrossRefPubMed Applegate K (2007) Pregnancy screening of adolescents and women before radiologic testing: does radiology need a national guideline? J Am Coll Radiol 4:533–536CrossRefPubMed
65.
go back to reference Goldman SM (2000) Overview of emergency radiological management of the pregnant patient, especially the traumatized pregnant patient. Emerg Radiol 7:198–205CrossRef Goldman SM (2000) Overview of emergency radiological management of the pregnant patient, especially the traumatized pregnant patient. Emerg Radiol 7:198–205CrossRef
66.
go back to reference Devine CE, Mawlawi O (2010) Radiation safety with positron emission tomography and computed tomography. Semin Ultrasound CT MR 31:39–45CrossRefPubMed Devine CE, Mawlawi O (2010) Radiation safety with positron emission tomography and computed tomography. Semin Ultrasound CT MR 31:39–45CrossRefPubMed
67.
go back to reference Jaffe TA, Neville AM, Anderson-Evans C et al (2009) Early first trimester fetal dose estimation method in a multivendor study of 16- and 64-MDCT scanners and low-dose imaging protocols. AJR Am J Roentgenol 193:1019–1024CrossRefPubMed Jaffe TA, Neville AM, Anderson-Evans C et al (2009) Early first trimester fetal dose estimation method in a multivendor study of 16- and 64-MDCT scanners and low-dose imaging protocols. AJR Am J Roentgenol 193:1019–1024CrossRefPubMed
68.
go back to reference Tutty L (2001) Risk/benefit ratios of perfusion scanning in the diagnosis of pulmonary embolus in pregnant patients. Radiography 7:227–234CrossRef Tutty L (2001) Risk/benefit ratios of perfusion scanning in the diagnosis of pulmonary embolus in pregnant patients. Radiography 7:227–234CrossRef
69.
go back to reference Bural GG, Laymon CM, Mountz JM (2012) Nuclear imaging of a pregnant patient: should we perform nuclear medicine procedures during pregnancy? Mol Imaging Radionucl Ther 21:1–5PubMedCentralCrossRefPubMed Bural GG, Laymon CM, Mountz JM (2012) Nuclear imaging of a pregnant patient: should we perform nuclear medicine procedures during pregnancy? Mol Imaging Radionucl Ther 21:1–5PubMedCentralCrossRefPubMed
70.
go back to reference Leung AN, Bull TM, Jaeschke R et al (2011) An official American Thoracic Society/Society of Thoracic Radiology clinical practice guideline: evaluation of suspected pulmonary embolism in pregnancy. Am J Respir Crit Care Med 184:1200–1208CrossRefPubMed Leung AN, Bull TM, Jaeschke R et al (2011) An official American Thoracic Society/Society of Thoracic Radiology clinical practice guideline: evaluation of suspected pulmonary embolism in pregnancy. Am J Respir Crit Care Med 184:1200–1208CrossRefPubMed
71.
go back to reference Rajaraman P, Simpson J, Neta G et al (2011) Early life exposure to diagnostic radiation and ultrasound scans and risk of childhood cancer: case–control study. BMJ 342:d472PubMedCentralCrossRefPubMed Rajaraman P, Simpson J, Neta G et al (2011) Early life exposure to diagnostic radiation and ultrasound scans and risk of childhood cancer: case–control study. BMJ 342:d472PubMedCentralCrossRefPubMed
72.
go back to reference Shu XO, Potter JD, Linet MS et al (2002) Diagnostic X-rays and ultrasound exposure and risk of childhood acute lymphoblastic leukemia by immunophenotype. Cancer Epidemiol Biomarkers Prev 11:177–185PubMed Shu XO, Potter JD, Linet MS et al (2002) Diagnostic X-rays and ultrasound exposure and risk of childhood acute lymphoblastic leukemia by immunophenotype. Cancer Epidemiol Biomarkers Prev 11:177–185PubMed
73.
go back to reference Bailey HD, Armstrong BK, de Klerk NH et al (2010) Exposure to diagnostic radiological procedures and the risk of childhood acute lymphoblastic leukemia. Cancer Epidemiol Biomarkers Prev 19:2897–2909CrossRefPubMed Bailey HD, Armstrong BK, de Klerk NH et al (2010) Exposure to diagnostic radiological procedures and the risk of childhood acute lymphoblastic leukemia. Cancer Epidemiol Biomarkers Prev 19:2897–2909CrossRefPubMed
74.
go back to reference Wallace GW, Davis MA, Semelka RC et al (2012) Imaging the pregnant patient with abdominal pain. Abdom Imaging 37:849–860CrossRefPubMed Wallace GW, Davis MA, Semelka RC et al (2012) Imaging the pregnant patient with abdominal pain. Abdom Imaging 37:849–860CrossRefPubMed
75.
go back to reference Weinreb JC (2008) Which study when? Is gadolinium-enhanced MR imaging safer than iodine-enhanced CT? Radiology 249:3–8CrossRefPubMed Weinreb JC (2008) Which study when? Is gadolinium-enhanced MR imaging safer than iodine-enhanced CT? Radiology 249:3–8CrossRefPubMed
76.
go back to reference Niemann T, Nicolas G, Roser HW et al (2010) Imaging for suspected pulmonary embolism in pregnancy-what about the fetal dose? A comprehensive review of the literature. Insights Imaging 1:361–372PubMedCentralCrossRefPubMed Niemann T, Nicolas G, Roser HW et al (2010) Imaging for suspected pulmonary embolism in pregnancy-what about the fetal dose? A comprehensive review of the literature. Insights Imaging 1:361–372PubMedCentralCrossRefPubMed
77.
go back to reference Tremblay E, Therasse E, Thomassin-Naggara I et al (2012) Quality initiatives: guidelines for use of medical imaging during pregnancy and lactation. Radiographics 32:897–911CrossRefPubMed Tremblay E, Therasse E, Thomassin-Naggara I et al (2012) Quality initiatives: guidelines for use of medical imaging during pregnancy and lactation. Radiographics 32:897–911CrossRefPubMed
78.
go back to reference Hodnett PA, Maher MM (2007) Imaging of gastrointestinal and hepatic diseases during pregnancy. Best Pract Res Clin Gastroenterol 21:901–917CrossRefPubMed Hodnett PA, Maher MM (2007) Imaging of gastrointestinal and hepatic diseases during pregnancy. Best Pract Res Clin Gastroenterol 21:901–917CrossRefPubMed
79.
go back to reference Kanal E, Barkovich AJ, Bell C et al (2013) ACR guidance document on MR safe practices: 2013. J Magn Reson Imaging 37:501–530CrossRefPubMed Kanal E, Barkovich AJ, Bell C et al (2013) ACR guidance document on MR safe practices: 2013. J Magn Reson Imaging 37:501–530CrossRefPubMed
80.
go back to reference Kanal E, Barkovich AJ, Bell C et al (2007) ACR guidance document for safe MR practices: 2007. AJR Am J Roentgenol 188:1447–1474CrossRefPubMed Kanal E, Barkovich AJ, Bell C et al (2007) ACR guidance document for safe MR practices: 2007. AJR Am J Roentgenol 188:1447–1474CrossRefPubMed
81.
82.
go back to reference Han BH, Lee KS, Han JY et al (2011) Pregnancy outcome after 1st-trimester inadvertent exposure to barium sulphate as a contrast media for upper gastrointestinal tract radiography. J Obstet Gynaecol 31:586–588CrossRefPubMed Han BH, Lee KS, Han JY et al (2011) Pregnancy outcome after 1st-trimester inadvertent exposure to barium sulphate as a contrast media for upper gastrointestinal tract radiography. J Obstet Gynaecol 31:586–588CrossRefPubMed
83.
go back to reference Ong SJ, Clarke L, Safar-Aly H et al (2011) Imaging the patient with suspected pulmonary venous thromboembolism. Br J Hosp Med (Lond) 72:M134–M137CrossRef Ong SJ, Clarke L, Safar-Aly H et al (2011) Imaging the patient with suspected pulmonary venous thromboembolism. Br J Hosp Med (Lond) 72:M134–M137CrossRef
84.
go back to reference Winer-Muram HT, Boone JM, Brown HL et al (2002) Pulmonary embolism in pregnant patients: fetal radiation dose with helical CT. Radiology 224:487–492CrossRefPubMed Winer-Muram HT, Boone JM, Brown HL et al (2002) Pulmonary embolism in pregnant patients: fetal radiation dose with helical CT. Radiology 224:487–492CrossRefPubMed
85.
go back to reference Mullins JK, Semins MJ, Hyams ES et al (2012) Half Fourier single-shot turbo spin-echo magnetic resonance urography for the evaluation of suspected renal colic in pregnancy. Urology 79:1252–1255CrossRefPubMed Mullins JK, Semins MJ, Hyams ES et al (2012) Half Fourier single-shot turbo spin-echo magnetic resonance urography for the evaluation of suspected renal colic in pregnancy. Urology 79:1252–1255CrossRefPubMed
86.
go back to reference Kahaleh M, Hartwell GD, Arseneau KO et al (2004) Safety and efficacy of ERCP in pregnancy. Gastrointest Endosc 60:287–292CrossRefPubMed Kahaleh M, Hartwell GD, Arseneau KO et al (2004) Safety and efficacy of ERCP in pregnancy. Gastrointest Endosc 60:287–292CrossRefPubMed
87.
go back to reference Casele H, Meyer J (2004) The selective use of magnetic resonance imaging in prenatal diagnosis. Ultrasound Obstet Gynecol 23:105–110CrossRefPubMed Casele H, Meyer J (2004) The selective use of magnetic resonance imaging in prenatal diagnosis. Ultrasound Obstet Gynecol 23:105–110CrossRefPubMed
88.
go back to reference Levine D (2001) Ultrasound versus magnetic resonance imaging in fetal evaluation. Top Magn Reson Imaging 12:25–38CrossRefPubMed Levine D (2001) Ultrasound versus magnetic resonance imaging in fetal evaluation. Top Magn Reson Imaging 12:25–38CrossRefPubMed
89.
go back to reference Forstner R, Kalbhen CL, Filly RA et al (1996) Abdominopelvic MR imaging in the nonobstetric evaluation of pregnant patients. Am J Roentgenol 166:1139–1144CrossRef Forstner R, Kalbhen CL, Filly RA et al (1996) Abdominopelvic MR imaging in the nonobstetric evaluation of pregnant patients. Am J Roentgenol 166:1139–1144CrossRef
90.
go back to reference Elster AD (1994) Does MR imaging have any known effects on the developing fetus? AJR Am J Roentgenol 162:1493CrossRefPubMed Elster AD (1994) Does MR imaging have any known effects on the developing fetus? AJR Am J Roentgenol 162:1493CrossRefPubMed
91.
go back to reference Hand JW, Li Y, Thomas EL et al (2006) Prediction of specific absorption rate in mother and fetus associated with MRI examinations during pregnancy. Magn Reson Med 55:883–893CrossRefPubMed Hand JW, Li Y, Thomas EL et al (2006) Prediction of specific absorption rate in mother and fetus associated with MRI examinations during pregnancy. Magn Reson Med 55:883–893CrossRefPubMed
92.
go back to reference Crook N, Robinson L (2009) A review of the safety implications of magnetic resonance imaging at field strengths of 3 Tesla and above. Radiography 15:351–356CrossRef Crook N, Robinson L (2009) A review of the safety implications of magnetic resonance imaging at field strengths of 3 Tesla and above. Radiography 15:351–356CrossRef
93.
go back to reference Kikuchi S, Saito K, Takahashi M et al (2010) Temperature elevation in the fetus from electromagnetic exposure during magnetic resonance imaging. Phys Med Biol 55:2411–2426CrossRefPubMed Kikuchi S, Saito K, Takahashi M et al (2010) Temperature elevation in the fetus from electromagnetic exposure during magnetic resonance imaging. Phys Med Biol 55:2411–2426CrossRefPubMed
94.
go back to reference Dumonceau JM, Garcia-Fernandez FJ, Verdun FR et al (2012) Radiation protection in digestive endoscopy: European Society of Digestive Endoscopy (ESGE) guideline. Endoscopy 44:408–421CrossRefPubMed Dumonceau JM, Garcia-Fernandez FJ, Verdun FR et al (2012) Radiation protection in digestive endoscopy: European Society of Digestive Endoscopy (ESGE) guideline. Endoscopy 44:408–421CrossRefPubMed
95.
go back to reference Al-Hashem H, Muralidharan V, Cohen H et al (2009) Biliary disease in pregnancy with an emphasis on the role of ERCP. J Clin Gastroenterol 43:58–62CrossRefPubMed Al-Hashem H, Muralidharan V, Cohen H et al (2009) Biliary disease in pregnancy with an emphasis on the role of ERCP. J Clin Gastroenterol 43:58–62CrossRefPubMed
96.
go back to reference Bates SM, Ginsberg JS (2002) How we manage venous thromboembolism during pregnancy. Blood 100:3470–3478CrossRefPubMed Bates SM, Ginsberg JS (2002) How we manage venous thromboembolism during pregnancy. Blood 100:3470–3478CrossRefPubMed
97.
go back to reference Litmanovich D, Boiselle PM, Bankier AA et al (2009) Dose reduction in computed tomographic angiography of pregnant patients with suspected acute pulmonary embolism. J Comput Assist Tomogr 33:961–966CrossRefPubMed Litmanovich D, Boiselle PM, Bankier AA et al (2009) Dose reduction in computed tomographic angiography of pregnant patients with suspected acute pulmonary embolism. J Comput Assist Tomogr 33:961–966CrossRefPubMed
99.
go back to reference Cook TS, Hilton S, Papanicolaou N (2013) Perspectives on radiation dose in abdominal imaging. Abdom Imaging 38:1190–1196CrossRefPubMed Cook TS, Hilton S, Papanicolaou N (2013) Perspectives on radiation dose in abdominal imaging. Abdom Imaging 38:1190–1196CrossRefPubMed
100.
go back to reference Birnbaum S (2010) Radiation protection in the era of helical CT: practical patient based programs for decreasing patient exposure. Semin Ultrasound CT MR 31:46–52CrossRefPubMed Birnbaum S (2010) Radiation protection in the era of helical CT: practical patient based programs for decreasing patient exposure. Semin Ultrasound CT MR 31:46–52CrossRefPubMed
101.
go back to reference Tan M, Huisman MV (2011) The diagnostic management of acute venous thromboembolism during pregnancy: recent advancements and unresolved issues. Thromb Res 127:S13–S16CrossRefPubMed Tan M, Huisman MV (2011) The diagnostic management of acute venous thromboembolism during pregnancy: recent advancements and unresolved issues. Thromb Res 127:S13–S16CrossRefPubMed
102.
go back to reference Iball GR, Kennedy EV, Brettle DS (2008) Modelling the effect of lead and other materials for shielding of the fetus in CT pulmonary angiography. Br J Radiol 81:499–503CrossRefPubMed Iball GR, Kennedy EV, Brettle DS (2008) Modelling the effect of lead and other materials for shielding of the fetus in CT pulmonary angiography. Br J Radiol 81:499–503CrossRefPubMed
103.
go back to reference Doshi SK, Negus IS, Oduko JM (2008) Fetal radiation dose from CT pulmonary angiography in late pregnancy: a phantom study. Br J Radiol 81:653–658CrossRefPubMed Doshi SK, Negus IS, Oduko JM (2008) Fetal radiation dose from CT pulmonary angiography in late pregnancy: a phantom study. Br J Radiol 81:653–658CrossRefPubMed
Metadata
Title
Risks to the fetus from diagnostic imaging during pregnancy: review and proposal of a clinical protocol
Authors
Mafalda Gomes
Alexandra Matias
Filipe Macedo
Publication date
01-12-2015
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Radiology / Issue 13/2015
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI
https://doi.org/10.1007/s00247-015-3403-z

Other articles of this Issue 13/2015

Pediatric Radiology 13/2015 Go to the issue