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Pediatric Radiology
Published in: Pediatric Radiology 11/2015

01-10-2015 | Original Article

Imaging of childhood inflammatory myofibroblastic tumor

Authors: Berna Oguz, Hatice Nursun Ozcan, Burak Omay, Burce Ozgen, Mithat Haliloglu

Published in: Pediatric Radiology | Issue 11/2015

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Abstract

Background

Inflammatory myofibroblastic tumor is a rare benign neoplasm and most commonly involves the lung but occurs in extrapulmonary locations.

Objective

To present imaging findings in inflammatory myofibroblastic tumors in children based on a single-centre experience.

Materials and methods

We retrospectively reviewed CT and MRI findings of children diagnosed with inflammatory myofibroblastic tumor in a single institution.

Results

We identified 15 children (range: 1–17 years) with inflammatory myofibroblastic tumor. The tumor was localized to the lung (n = 5), mediastinum (n = 3), trachea (n = 1), bronchus (n = 1), abdomen (n = 2) and orbit (n = 3). All the extraorbital tumors were solid masses with homogeneous or heterogeneous enhancement. Four lung tumors and one posterior mediastinal tumor contained calcification. Local recurrence following surgical removal occurred in two children with invasion of the esophagus and of the left atrium in one. Localized masses were seen in all children with orbital tumour. Two of these had episcleritis and perineuritis; one had episcleritis, tendonitis, perineuritis, myositis and dacryoadenitis.

Conclusion

The locations and imaging features of inflammatory myofibroblastic tumors are variable.
Literature
1.
Hedlund GL, Navoy JF, Galliani CA et al (1999) Aggressive manifestations of inflammatory pulmonary pseudotumor in children. Pediatr Radiol 29:112–116CrossRefPubMed
2.
Patankar T, Prasad S, Shenoy A et al (2000) Pulmonary inflammatory pseudotumor in children. Australas Radiol 44:318–320CrossRefPubMed
3.
Karnak I, Senocak ME, Ciftci AO et al (2001) Inflammatory myofibroblastic tumor in children: diagnosis and treatment. J Pediatr Surg 36:908–912CrossRefPubMed
4.
Patnana M, Sevrukov AB, Elsayes KM et al (2012) Inflammatory pseudotumor: the great mimicker. AJR Am J Roentgenol 198:W217–W227CrossRefPubMed
5.
Narla LD, Newman B, Spottswood SS et al (2003) Inflammatory pseudotumor. Radiographics 23:719–729CrossRefPubMed
6.
Kim SJ, Kim WS, Cheon JE et al (2009) Inflammatory myofibroblastic tumors of the abdomen as mimickers of malignancy: imaging features in nine children. AJR Am J Roentgenol 193:1419–1424CrossRefPubMed
7.
Choi BY, Kim WS, Cheon JE et al (2003) Inflammatory myofibroblastic tumour of the liver in a child: CT and MR findings. Pediatr Radiol 33:30–33CrossRefPubMed
8.
Day DL, Sane S, Dehner LP (1986) Inflammatory pseudotumor of the mesentery and small intestine. Pediatr Radiol 16:210–215CrossRefPubMed
9.
Taratuta E, Krinsky G, Genega E et al (1996) Pediatric inflammatory pseudotumor of the stomach: contrast-enhanced CT and MR imaging findings. AJR Am J Roentgenol 167:919–920CrossRefPubMed
10.
Sanders BM, West KW, Gingalewski C et al (2001) Inflammatory pseudotumor of the alimentary tract: clinical and surgical experience. J Pediatr Surg 36:169–173CrossRefPubMed
11.
Park SB, Cho KS, Kim JK et al (2008) Inflammatory pseudotumor (myoblastic tumor) of the genitourinary tract. AJR Am J Roentgenol 191:1255–1262CrossRefPubMed
12.
Brunn H (1939) Two interesting benign lung tumours of contradictory histopathology: remarks on the necessity for maintaining the chest tumour registry. J Thorac Cardiovasc 9:119–131
13.
Umiker WO, Iverson LC (1954) Post inflammatory tumor of the lung: report of four cases simulating xanthoma, fibroma or plasma cell granuloma. J Thorac Surg 28:55–62PubMed
14.
Kirkpatrick JA Jr, Harris GB, Kushner DC (1984) Thoracic complications of plasma cell granuloma of the lung. Ann Radiol 27:145–149PubMed
15.
Cook JR, Dehner LP, Collins MH et al (2001) Anaplastic lymphoma kinase (ALK) expression in the inflammatory myofibroblastic tumor: a comparative immunohistochemical study. Am J Surg Pathol 25:1364–1368CrossRefPubMed
16.
17.
Priebe-Richter C, Ivanyi P, Buer J et al (2005) Inflammatory pseudotumor of the lung following invasive aspergillosis in a patient with chronic graft-vs.-host disease. Eur J Haematol 75:68–72CrossRefPubMed
18.
Takayama Y, Yabuuchi H, Matsuo Y et al (2008) Computed tomographic and magnetic resonance features of inflammatory myofibroblastic tumor of the lung in children. Radiat Med 26:613–617CrossRefPubMed
19.
Yan FH, Zhou KR, Jiang YP et al (2001) Inflammatory pseudotumor of the liver: 13 cases of MRI findings. World J Gastroenterol 7:422–424PubMed
20.
McCarville MB, Hoffer FA, Adelman S et al (2007) MRI and biological behavior of desmoid tumors in children. AJR Am J Roentgenol 189:633–640CrossRefPubMed
21.
Huellner MW, Schwizer B, Burger I et al (2010) Inflammatory pseudotumor of the lung with high FDG uptake. Clin Nucl Med 35:722–723CrossRefPubMed
22.
Alongi F, Bolognesi A, Gajate AM et al (2010) Inflammatory pseudotumor of mediastinum treated with tomotherapy and monitored with FDG-PET/CT: case report and literature review. Tumori 96:322–326PubMed
23.
Athanassiadi K, Laenger F, Dickgreber N et al (2009) Multiple inflammatory myofibroblastic tumors involving lung and mediastinum: a rare clinical entity. Thorac Cardiov Surg 57:343–346CrossRef
24.
Corneli G, Alifano M, Forti Parri S et al (2001) Invasive inflammatory pseudotumor involving the lung and mediastinum. Thorac Cardiovasc Surg 49:124–126CrossRefPubMed
25.
Li L, Burke A, He J et al (2011) Sudden unexpected death due to inflammatory myofibroblastic tumor of the heart: a case report and review of the literature. Int J Legal Med 125:81–85CrossRefPubMed
26.
Sugiyama K, Nakajima Y (2008) Inflammatory myofibroblastic tumor in the mediastinum mimicking a malignant tumor. Diagn Interv Radiol 14:197–199PubMed
27.
Guan Y, Chen G, Zhang W et al (2012) Computed tomography appearance of inflammatory myofibroblastic tumor in the mediastinum. J Comput Assist Tomogr 36:654–658CrossRefPubMed
28.
Dhouib A, Barrazzone C, Reverdin A et al (2013) Inflammatory myofibroblastic tumor of the lung: a rare cause of atelectasis in children. Pediatr Radiol 43:381–384CrossRefPubMed
29.
De Palma A, Loizzi D, Sollitto F et al (2009) Surgical treatment of a rare case of tracheal inflammatory pseudotumor in pediatric age. Interact Cardiovasc Thorac Surg 9:1035–1037CrossRefPubMed
30.
Franquet T, Montes M, Aizcorbe M et al (1989) Inflammatory pseudotumor of the spleen: ultrasound and computed tomographic findings. Gastrointest Radiol 14:181–183CrossRefPubMed
31.
Tublin ME, Moser AJ, Marsh JW et al (2007) Biliary inflammatory pseudotumor: imaging features in seven patients. AJR Am J Roentgenol 188:W44–W48CrossRefPubMed
32.
Uysal S, Tuncbilek I, Unlubay D et al (2005) Inflammatory pseudotumor of the sigmoid colon mesentery: US and CT findings. Eur Radiol 15:633–635CrossRefPubMed
33.
Slavotinek JP, Bourne AJ, Sage MR et al (2000) Inflammatory pseudotumor of the pancreas in a child. Pediatr Radiol 30:801–803CrossRefPubMed
34.
Lee HJ, Kim JS, Choi YS et al (2007) Treatment of inflammatory myofibroblastic tumor of the chest: the extent of resection. Ann Thorac Surg 84:221–224CrossRefPubMed
35.
Melloni G, Caretta A, Ciriaco P et al (2005) Inflammatory pseudotumor of the lung in adults. Ann Thorac Surg 79:426–432CrossRefPubMed
36.
Belanger C, Zhang KS, Reddy AK et al (2010) Inflammatory disorders of the orbit in childhood: a case series. Am J Ophthalmol 150:460–463CrossRefPubMed
37.
Weber AL, Romo LV, Sabates NR (1999) Pseudotumor of the orbit: clinical, pathologic, and radiologic evaluation. Radiol Clin North Am 37:151–168CrossRefPubMed
38.
39.
Martin CJ (1997) Orbital pseudotumor: a case report and overview. J Am Optom Assoc 68:775–781PubMed
40.
Sepahdari AR, Aakalu VK, Setabutr P et al (2010) Indeterminate orbital masses: restricted diffusion at MR imaging with echo-planar diffusion-weighted imaging predicts malignancy. Radiology 256:554–564CrossRefPubMed
41.
Mombaerts J, Sachlingermann RO, Koorneef L (1996) Are systemic corticosteroids useful in the management of orbital pseudotumors. Ophthalmology 103:521–528CrossRefPubMed
42.
Cherukupally SR, Mankarious LA, Fraquin W et al (2003) Pediatric non-orbital pseudotumor of the head and neck. Int J Pediatr Otorhinolaryngol 67:649–653CrossRefPubMed
43.
Park SB, Lee JH, Weon YC (2009) Imaging findings of head and neck inflammatory pseudotumor. AJR Am J Roentgenol 193:1180–1186CrossRefPubMed
44.
45.
Weber MA, Wiehoever A, Stieltjes B et al (2005) Intracerebral manifestation of an atypical monoclonal plasma cell hyperplasia depicted by MR perfusion and diffusion tensor imaging and MR spectroscopy. AJR Am J Roentgenol 185:784–787CrossRefPubMed
Metadata
Title
Imaging of childhood inflammatory myofibroblastic tumor
Authors
Berna Oguz
Hatice Nursun Ozcan
Burak Omay
Burce Ozgen
Mithat Haliloglu
Publication date
01-10-2015
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Radiology / Issue 11/2015
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI
https://doi.org/10.1007/s00247-015-3377-x

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