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Pediatric Radiology
Published in: Pediatric Radiology 8/2014

01-08-2014 | Case Report

All-trans retinoic acid-induced inflammatory myositis in a patient with acute promyelocytic leukemia

Authors: Lydia H. Pecker, Jason Tsai, Anne Angiolillo

Published in: Pediatric Radiology | Issue 8/2014

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Abstract

All-trans retinoic acid (ATRA), a component of standard therapy for acute promyelocytic leukemia (APL), is associated with potentially serious but treatable adverse effects involving numerous organ systems, including rare skeletal muscle involvement. Only a handful of cases of ATRA-induced myositis in children have been reported, and none in the radiology literature. We present such a case in a 15-year-old boy with APL, where recognition of imaging findings played a crucial role in making the diagnosis and facilitated prompt, effective treatment.
Literature
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Chan KH, Yuen SLS, Joshua D (2005) A case of all-trans retinoic acid induced myositis in the treatment of acute promyelocytic leukemia. Clin Lab Haematol 27:399–401PubMedCrossRef
2.
Citak FE, Ezer U, Akkaya E et al (2006) All-trans-retinoic acid-induced myositis in a child with promyelocytic leukemia. Haemotologica 91:ECR 35
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Melinkeri SR, Gupta RK, Dabadghao S (2002) A Sweet-like syndrome manifesting as gingival hyperplasia and myositis without cutaneous involvement. Ann Hematol 81:397–398PubMedCrossRef
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Manglani MV, Balamurugan P (2009) All-trans-retinoic acid (ATRA) induced myositis. Indian Pediatr 46:912–913PubMed
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van Der Vliet HJ, Roberson AE, Hogan MC et al (2000) All-trans-retinoic acid-induced myositis: a description of two patients. Am J Hematol 63:94–98CrossRef
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Montesinos P, Bergua JM, Vellenga E et al (2009) Differentiation syndrome in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline chemotherapy: characteristics, outcome, and prognostic factors. Blood 113:775–783PubMedCrossRef
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Fisher BT, Singh S, Huang Y et al (2013) Induction mortality, ATRA administration, and resource utilization in a nationally representative cohort of children with acute promyelocytic leukemia in the United States from 1999 to 2009. Pediatr Blood Cancer 61:68–73PubMedCentralPubMedCrossRef
Metadata
Title
All-trans retinoic acid-induced inflammatory myositis in a patient with acute promyelocytic leukemia
Authors
Lydia H. Pecker
Jason Tsai
Anne Angiolillo
Publication date
01-08-2014
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Radiology / Issue 8/2014
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI
https://doi.org/10.1007/s00247-014-2951-y

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