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01-06-2012 | Original Article

MRI assessment of bone marrow in children with juvenile idiopathic arthritis: intra- and inter-observer variability

Authors: Laura Tanturri de Horatio, Maria Beatrice Damasio, Domenico Barbuti, Claudia Bracaglia, Karen Lambot-Juhan, Peter Boavida, Lil-Sofie Ording Müller, Clara Malattia, Lucilla Ravà, Karen Rosendahl, Paolo Tomà

Published in: Pediatric Radiology | Issue 6/2012

Abstract

Background

Bone marrow oedema (BMO) is included in MRI-based scoring systems of disease activity in adults with rheumatoid arthritis. Similar systems in juvenile idiopathic arthritis (JIA) are lacking.

Objective

To assess the reproducibility in a multi-centre setting of an MRI BMO scoring system in children with JIA.

Materials and methods

Seventy-six wrist MRIs were read twice, independently, by two experienced paediatric radiologists. BMO was defined as ill-defined lesions within the trabecular bone, returning high and low signal on T2- and T1-weighted images respectively, with or without contrast enhancement. BMO extension was scored for each of 14 bones at the wrist from 0 (none) to 3 (extensive).

Results

The intra-observer agreement was moderate to excellent, with weighted kappa ranging from 0.85 to 1.0 and 0.49 to 1.0 (readers 1 and 2 respectively), while the inter-observer agreement ranged from 0.41 to 0.79. The intra- and inter-observer intraclass correlation coefficients were excellent and satisfactory, respectively.

Conclusion

The scoring system was reliable and may be used for grading bone marrow abnormality in JIA. The relatively large variability in aggregate scores, particularly between readers, underscores the need for thorough standardisation.

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Title: MRI assessment of bone marrow in children with juvenile idiopathic arthritis: intra- and inter-observer variability
Authors: Laura Tanturri de Horatio
Maria Beatrice Damasio
Domenico Barbuti
Claudia Bracaglia
Karen Lambot-Juhan
Peter Boavida
Lil-Sofie Ording Müller
Clara Malattia
Lucilla Ravà
Karen Rosendahl
Paolo Tomà
Publication date: 01-06-2012
Publisher: Springer-Verlag
Published in: Pediatric Radiology / Issue 6/2012
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-012-2345-y

At a glance: The STEP trials

Springer Medicine

MRI assessment of bone marrow in children with juvenile idiopathic arthritis: intra- and inter-observer variability

Abstract

Background

Objective

Materials and methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Objective

Materials and methods

Results

Conclusion

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