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Published in:

01-11-2010 | Original Article

PET assessment of disease activity in children with juvenile idiopathic arthritis

Authors: Ukihide Tateishi, Tomoyuki Imagawa, Noriko Kanezawa, Tetsuhiko Okabe, Kazuya Shizukuishi, Tomio Inoue, Shumpei Yokota

Published in: Pediatric Radiology | Issue 11/2010

Abstract

Background

The degree of 18-fluorodeoxyglucose (FDG) uptake is previously reported to correlate with physical examination and laboratory tests for evaluating disease activity in patients with rheumatoid arthritis. The clinical validity of ¹⁸F-FDG positron emission tomography (PET) has not been evaluated in juvenile idiopathic arthritis (JIA).

Objective

To assess the relationship between ¹⁸F-FDG PET uptake and disease activity in children with JIA.

Materials and methods

A total of 560 joints in 28 children (mean age, 5.4 years; range, 1–16 years) with JIA who had undergone whole-body ¹⁸F-FDG PET before treatment were retrospectively assessed clinically, biochemically and radiographically. PET images were assessed independently by two readers. We investigated the relationships between the degree of synovial ¹⁸F-FDG uptake and radiographic and clinical symptoms and laboratory findings.

Results

Joint tenderness and swelling had a positive association with abnormal ¹⁸F-FDG uptake in the joint [odds ratio (OR) 5.37, 7.12, respectively]. The standardized uptake value (SUV) max correlated with the neutrophil count, plasma C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and matrix metalloproteinase (MMP) 3. Joint erosion (OR, 6.17), soft-tissue swelling (OR, 3.77), major joints involvement (OR, 3.50), tenderness (OR, 5.22), and CRP concentration in plasma (OR, 1.81) were positively associated with SUVmax.

Conclusion

The degree of ¹⁸F-FDG uptake may be associated with the severity of synovitis in children with JIA.

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Title: PET assessment of disease activity in children with juvenile idiopathic arthritis
Authors: Ukihide Tateishi
Tomoyuki Imagawa
Noriko Kanezawa
Tetsuhiko Okabe
Kazuya Shizukuishi
Tomio Inoue
Shumpei Yokota
Publication date: 01-11-2010
Publisher: Springer-Verlag
Published in: Pediatric Radiology / Issue 11/2010
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-010-1716-5

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

PET assessment of disease activity in children with juvenile idiopathic arthritis

Abstract

Background

Objective

Materials and methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Objective

Materials and methods

Results

Conclusion

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