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01-07-2007 | Original Article

Coronary magnetic resonance angiography and vessel wall imaging in children with Kawasaki disease

Authors: Gerald F. Greil, Achim Seeger, Stephan Miller, Claus D. Claussen, Michael Hofbeck, René M. Botnar, Ludger Sieverding

Published in: Pediatric Radiology | Issue 7/2007

Abstract

Background

In patients with Kawasaki disease (KD) serial evaluation of the distribution and size of coronary artery aneurysms (CAA) is necessary for risk stratification and therapeutic management.

Objective

To apply whole-heart coronary MR angiography (CMRA) and black-blood coronary vessel wall imaging in children with KD.

Materials and methods

Six children (mean age 4.6 years, range 2.5–7.8 years) with KD underwent CMRA using a free-breathing, T2-prepared, three-dimensional steady-state free-precession (3D-SSFP), whole-heart approach with navigator gating and tracking. Vessel walls were imaged with an ECG-triggered and navigator-gated double inversion recovery (DIR) black-blood segmented turbo spin-echo sequence.

Results

There was complete agreement between CMRA and conventional angiography (n=6) in the detection of CAA (n=15). Excellent agreement was found between the two techniques in determining the maximal diameter (mean difference 0.2±0.7 mm), length (mean difference 0.1±0.8 mm) and distance from the ostium (mean difference −0.8±2.1 mm) of the CAAs. In all subjects with a CAA, abnormally thickened vessel walls were found (2.5±0.5 mm).

Conclusions

CMRA accurately defines CAA in free-breathing sedated children with KD using the whole-heart approach and detects abnormally thickened vessel walls. This technique may reduce the need for serial X-ray coronary angiography, and improve risk stratification and monitoring of therapy.

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Title: Coronary magnetic resonance angiography and vessel wall imaging in children with Kawasaki disease
Authors: Gerald F. Greil
Achim Seeger
Stephan Miller
Claus D. Claussen
Michael Hofbeck
René M. Botnar
Ludger Sieverding
Publication date: 01-07-2007
Publisher: Springer-Verlag
Published in: Pediatric Radiology / Issue 7/2007
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-007-0498-x

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Coronary magnetic resonance angiography and vessel wall imaging in children with Kawasaki disease

Abstract

Background

Objective

Materials and methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Objective

Materials and methods

Results

Conclusions

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