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01-10-2019 | Cytokines | Original Paper

Adolescents with urinary stones have elevated urine levels of inflammatory mediators

Authors: Kirsten Kusumi, John Ketz, Vijay Saxena, John David Spencer, Fayez Safadi, Andrew Schwaderer

Published in: Urolithiasis | Issue 5/2019

Abstract

Urinary stones are increasing in children, primarily during adolescence. Although urinary stones are often viewed in the context of intermittent stone events, increasing evidence indicates that stones are a metabolic process associated with chronic kidney disease and cardiovascular disease. These aforementioned stone-associated conditions may have pediatric origins. To compare urine inflammatory markers in otherwise healthy stone forming children versus matched controls. Urine samples were collected from 12 adolescents with urinary stones along with 15 controls. The levels of 30 urine cytokines were measured using a Mesoscale 30-Plex Human Cytokine panel and normalized to urine creatinine levels. Macrophage inflammatory protein 1β and interleukin 13 levels were significantly elevated in the urine of the stone forming adolescents compared to controls. Interleukin 17A was elevated in the urine of controls. This study indicates that urine levels of cytokines involved in chronic inflammation and fibrosis are elevated in urinary stone formers as early as adolescence. Because stone formers are at risk for chronic kidney disease, macrophage inflammatory protein 1β and interleukin 13 represent investigative targets.

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Title: Adolescents with urinary stones have elevated urine levels of inflammatory mediators
Authors: Kirsten Kusumi
John Ketz
Vijay Saxena
John David Spencer
Fayez Safadi
Andrew Schwaderer
Publication date: 01-10-2019
Publisher: Springer Berlin Heidelberg
Keywords: Cytokines
Chronic Kidney Disease
Published in: Urolithiasis / Issue 5/2019
Print ISSN: 2194-7228
Electronic ISSN: 2194-7236
DOI: https://doi.org/10.1007/s00240-019-01133-1

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Adolescents with urinary stones have elevated urine levels of inflammatory mediators

Abstract

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Abstract

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