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Urolithiasis
Published in: Urolithiasis 4/2015

01-08-2015 | Original Paper

Biochemical diagnosis in 3040 kidney stone formers in Argentina

Authors: Francisco Rodolfo Spivacow, Elisa Elena del Valle, Armando Luis Negri, Erich Fradinger, Anabella Abib, Paula Rey

Published in: Urolithiasis | Issue 4/2015

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Abstract

Nephrolithiasis is a frequent condition in urology that has an important recurrence and high impact in health economy. Knowing the biochemical abnormalities implicated in its pathogenesis is mandatory to establish therapeutic aims. Our objectives are to present the results in 3040 kidney stone formers in Argentina. All patients were selected after completing an ambulatory metabolic protocol with diagnostic purposes. There were 1717 men, (56.48 %), with a mean age of 45 ± 12 years, and 1323 women, (43.52 %), mean age 44 ± 12 years. 2781 patients had biochemical abnormalities, (91.49 %), and were arbitrarily divided in two groups: those who had only one (single) biochemical abnormality (n = 2156) and those who had associated abnormalities (n = 625). No biochemical abnormalities were found in 259 patients (8.51 %). The abnormalities present, single and associated, in order of frequency, were idiopathic hypercalciuria, (56.88 %), hyperuricosuria (21.08 %), unduly acidic urine (10.95 %), hypocitraturia (10.55 %), hypomagnesuria (7.9 %), primary hyperparathyroidism (3.01 %), hyperoxaluria (2.6 %), and cystinuria (0.32 %). We performed in 484 patient’s stone composition and found calcium oxalate stones related to idiopathic hypercalciuria predominantly while uric acid stones to unduly acidic urine. In conclusion, the biochemical abnormalities described are similar to those found in a previous series of our own and to those reported in the literature. Its diagnosis is important to therapeutic purposes to avoid eventual recurrence.
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Metadata
Title
Biochemical diagnosis in 3040 kidney stone formers in Argentina
Authors
Francisco Rodolfo Spivacow
Elisa Elena del Valle
Armando Luis Negri
Erich Fradinger
Anabella Abib
Paula Rey
Publication date
01-08-2015
Publisher
Springer Berlin Heidelberg
Published in
Urolithiasis / Issue 4/2015
Print ISSN: 2194-7228
Electronic ISSN: 2194-7236
DOI
https://doi.org/10.1007/s00240-015-0778-0

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