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Urolithiasis
Published in: Urolithiasis 3/2005

01-06-2005 | Original Paper

A novel antioxidant agent caffeic acid phenethyl ester prevents shock wave-induced renal tubular oxidative stress

Authors: Fehmi Ozguner, Abdullah Armagan, Ahmet Koyu, Sadettin Calıskan, Halis Koylu

Published in: Urolithiasis | Issue 3/2005

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Abstract

The aim of this study was to evaluate the effects of the novel free radical scavenger caffeic acid phenethyl ester (CAPE) on extracorporeal shock wave lithotripsy (ESWL) induced renal impairment. The study was performed using 30 rabbits which were divided into two groups, each exposed to 3,000 shock waves at 18 kV: (1) control group, (2) ESWL+CAPE treated group. Malodialdehyde (MDA), urine N-acetyl-β-glucosaminidase (NAG) activity, uric acid and white cell counts were used as markers of oxidative stress. Following shock wave exposure there was a significant rise in MDA, NAG and uric acid and white cell counts. CAPE reduced the rise in MDA, NAG, uric acid and white cell counts. Thus CAPE treatment to a great extent prevented the induction of these renal changes. Our results suggest that the antioxidant capacity of the kidney tissue was reduced after ESWL treatment and that the tissue was exposed to oxidant stress. We conclude that CAPE treatment provided significant protection against ESWL induced free radical damage.
Literature
1.
Strohmaier WL, Lahme S, Weidenbach PM, Bichler KH (1999) Reduction of high-energy shock-wave-induced renal tubular injury by selenium. Urol Res 27: 382CrossRefPubMed
2.
Biri H, Ozturk HS, Buyukkocak S, Kacmaz M, Cimen MY, Unal D, Birey M, Bozkirli I, Durak I (1998) Antioxidant defense potential of rabbit renal tissues after ESWL: protective effects of antioxidant vitamins. Nephron 79: 181CrossRefPubMed
3.
Morgan TR, Laudone PV, Heston WD, Zeitz L, Fair WR (1988) Free radical production by high energy shock waves comparison with ionising irradiation. J Urol 139: 186PubMed
4.
Suhr D, Brummer F, Hulcer DF (1991) Cavitation-generated free radicals during shock wave exposure: investigations with cell-free solutions and suspended cells. Ultrasound Med Biol 17: 761CrossRefPubMed
5.
Kirkali Z, Kirkali G, Tahiri Y (1994) The effect of extracorporeal electromagnetic shock waves on renal proximal tubular function. Int Urol Nephrol 26: 255PubMed
6.
Crum LA (1988) Cavitation microjets as a contributory mechanism for renal calculus disintegration in ESWL. J Urol 140: 1587PubMed
7.
Serel TA, Ozguner F, Soyupek S (2004) Prevention of shock wave-induced renal oxidative stress by melatonin: an experimental study. Urol Res 32: 69CrossRefPubMed
8.
Bosomworth MP, Aparicio SR, Hay AWM (1999) Urine N-acetyl-β-D-glucosaminidase-A marker of tubular damage. Nephrol Dial Transplant 14: 620CrossRefPubMed
9.
Raab WP (1972) Diagnostic value of urinary enzyme determinations. Clin Chem 18: 5PubMed
10.
Ilhan A, Koltuksuz U, Ozen S, Uz E, Ciralik H, Akyol O (1999) The effects of caffeic acid phenethyl ester (CAPE) on spinal cord ischemia/reperfusion injury in rabbits. Eur J Cardiothorac Surg 16: 458CrossRefPubMed
11.
Rao C, Desai D, Kaul B, Amin S, Reddy BS (1992) Effect of caffeic acid esters on carcinogen-induced mutagenicity and human colon adenocarcinoma cell growth. Chem Biol Interact 84: 277CrossRefPubMed
12.
Sud’ina GF, Mirzoeva OK, Pushkareva GA, Korshunova GA, Sumbatyan NV, Varfolomeev SD (1993) Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties. FEBS Lett 329: 21CrossRefPubMed
13.
Michaluart P, Masferrer JL, Carothers AM, Subbaramaiah K, Zweifel BS, Koboldt C, Mestre JR, Grunberger D, Sacks PG, Tanabe T, Dannenberg AJ (1999) Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in rat model of inflammation. Cancer Res 59: 2347PubMed
14.
Chen YJ, Shiao MS, Wang SY (2001) The antioxidant caffeic acid phenethyl ester induces apoptosis associated with selective scavenging of hydrogen peroxide in human leukemic HL-60 cells. Anticancer Drugs 12: 143CrossRefPubMed
15.
Fesen MR, Pommier Y, Leteurtre E, Hiroguchi S, Yung J, Kohn KW (1994) Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds. Biochem Pharmacol 48: 595CrossRefPubMed
16.
Park EH, Kahng JH (1999) Suppressive effects of propolis in rat adjuvant arthritis. Arch Pharm Res 22: 554PubMed
17.
Hepsen IF, Er H, Cekic O (1999) Topically applied water extract of propolis to suppress corneal neovascularization in rabbits. Ophthalmic Res 31: 426CrossRefPubMed
18.
Gurel A, Armutcu F, Sahin S, Sogut S, Ozyurt H, Gulec M, Kutlu NO, Akyol O (2004) Protective role of alphatocopherol and caffeic acid phenethyl ester on ischemia-reperfusion injury via nitric oxide and myeloperoxidase in rat kidneys. Clin Chim Acta 339: 33CrossRefPubMed
19.
Uz E, Sogut S, Sahin S, Var A, Ozyurt H, Gulec M, Akyol O (2002) The protective role of caffeic acid phenethyl ester (CAPE) on testicular tissue after testicular torsion and detorsion. World J Urol 20: 264PubMed
20.
Yilmaz HR, Uz E, Yucel N, Altuntas I, Ozcelik N (2004) Protective effect of caffeic acid phenethyl ester (CAPE) on lipid peroxidation and antioxidant enzymes in diabetic rat liver. J Biochem Mol Toxicol 18: 234CrossRefPubMed
21.
Draper HH, Hadley M (1990) Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol 186: 421PubMed
22.
Yakata M, Sugita O, Sakai T, Uchiyama K, Wada K (1983) Urinary enzyme determination and its clinical significance. C. Enzyme derived from the kidney epithelium-N acetyl.beta-D-glucosaminidase. 4. Preclinical evaluation of the urinary NAG activity and changes in the renal disease. Rinsho Byori 56: 90
23.
Rovin BH, Wurst E, Kohan DE (1990) Production of reactive oxygen species by tubular epithelium in cell culture. Kidney Int 37: 1509PubMed
24.
Everaert K, Kerckhaert W, Delanghe J, Lameire N, Sturley W, Van de Wiele C, Dierckx RA, Van de Voorde J, Oosterlinck W (1998) Elevated tubular proteinuria, albuminuria and decreased urinary N-acetyl-beta-D-glucosaminidase activity following unilateral total ureteral obstruction in rats. Urol Res 26: 285CrossRefPubMed
25.
Kunin CM, Chesney RW, Craig WA, England AC, DeAngelis C (1978) Enzymuria as a marker of renal injury and disease: studies of N-acetyl-β-glucosaminidase in the general population and in patients with renal disease. Pediatrics 62: 751PubMed
26.
Sarica K, Kosar A, Yaman O, Beduk Y, Durak I, Gogus O, Kavukcu M (1996) Evaluation of ischemia after ESWL: detection of free oxygen radical scavenger enzymes in renal parenchyma subjected to high-energy shock waves. Urol Int 57: 221PubMed
27.
Yaman O, Sarica K, Ozer G, Soygur T, Kutsal O, Yaman LS, Gous O (1996) Protective effect of verapamil on renal tissue during shockwave application in rabbit model. J Endourol 10: 329PubMed
28.
Sener G, Paskaloglu K, Toklu H, Kapucu C, Ayanoglu-Dulger G, Kacmaz A, Sakarcan A (2004) Melatonin ameliorates chronic renal failure-induced oxidative organ damage in rats. J Pineal Res 36: 232CrossRefPubMed
29.
Sakamoto W, Kishimoto T, Nakatani T, Ameno Y, Ohyama A, Kamizuru M, Yasumoto R, Maekawa M (1991) Examination of aggravating factors of urinary excretion of N-acetyl-beta-D-glucosaminidase after extracorporeal shock wave lithotripsy. Nephron 58: 20
30.
Strohmaier WL, Koch J, Wilbert DM, Bichler KH (1991) Protective effects of verapamil on shock wave induced tubular dysfunction. J Urol150: 27
Metadata
Title
A novel antioxidant agent caffeic acid phenethyl ester prevents shock wave-induced renal tubular oxidative stress
Authors
Fehmi Ozguner
Abdullah Armagan
Ahmet Koyu
Sadettin Calıskan
Halis Koylu
Publication date
01-06-2005
Publisher
Springer-Verlag
Published in
Urolithiasis / Issue 3/2005
Print ISSN: 2194-7228
Electronic ISSN: 2194-7236
DOI
https://doi.org/10.1007/s00240-005-0470-x

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