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European Journal of Plastic Surgery
Published in: European Journal of Plastic Surgery 2/2017

01-04-2017 | Review

Platelet biology and the rationale of PRP therapy in chronic wounds

Authors: Domantas Rainys, Gediminas Samulėnas, Mantas Kievišas, Eglė Samulėnienė, Loreta Pilipaitytė, Rytis Rimdeika

Published in: European Journal of Plastic Surgery | Issue 2/2017

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Abstract

For the past four decades, platelets have been thought to function only in hemostatic processes. With reference to recent research, today, it is known that platelets also play important roles in tissue regeneration and immunological processes. The keystone of the use of platelet-rich plasma (PRP) for the treatment of chronic wounds lays in the molecular composition of thrombocytes, which are rich in growth factors and other biologically active substances. PRP forms a matrix for cells and thus promotes wound healing processes. Harvesting PRP is relatively uncomplicated, minimally invasive, and potentially available for each patient. In this review, we provide an overview of the biology of the thrombocyte to better understand the effects of PRP. Additionally, we reviewed published studies, analyzing the effectiveness of PRP for the treatment of chronic wounds.
Level of evidence: Not ratable.
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Metadata
Title
Platelet biology and the rationale of PRP therapy in chronic wounds
Authors
Domantas Rainys
Gediminas Samulėnas
Mantas Kievišas
Eglė Samulėnienė
Loreta Pilipaitytė
Rytis Rimdeika
Publication date
01-04-2017
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Plastic Surgery / Issue 2/2017
Print ISSN: 0930-343X
Electronic ISSN: 1435-0130
DOI
https://doi.org/10.1007/s00238-017-1279-x

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