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Published in: European Journal of Plastic Surgery 5/2016

01-10-2016 | Case Report

Lipofilling may induce nerve regeneration after previous traumatic injury: a clinical case with remarkable outcome

Authors: Geraldine L. Nanninga, Tim H. Nijhuis, Rutger M. Schols, Sjoerd B. Paulusma, J. Henk Coert, Jean Bart Jaquet

Published in: European Journal of Plastic Surgery | Issue 5/2016

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Abstract

Despite the fast amount of techniques, which promote nerve regeneration, the outcomes of high ulnar nerve injuries are still poor. This case report illuminates the usability of lipofilling in peripheral nerve regeneration. In the case described, we encountered a successful regeneration with return of sensibility and motor function. We believe that the rationale for this technique is the presence of adipose-derived stem cells (ADSCs). We speculate that this improvement depends on tissue regeneration induced by these ADSCs.
Level of Evidence: Level V, therapeutic study.
Literature
1.
go back to reference di Summa PG, Kalbermatten DF, Raffoul W et al (2013) Extracellular matrix molecules enhance the neurotrophic effect of Schwann cell-like differentiated adipose-derived stem cells and increase cell survival under stress conditions. Tissue Eng Part A 19(3–4):368–379 di Summa PG, Kalbermatten DF, Raffoul W et al (2013) Extracellular matrix molecules enhance the neurotrophic effect of Schwann cell-like differentiated adipose-derived stem cells and increase cell survival under stress conditions. Tissue Eng Part A 19(3–4):368–379
2.
go back to reference Hundepool CA, Nijhuis TH, Mohseny B et al (2014) The effect of stem cells in bridging peripheral nerve defects: a meta-analysis. J Neurosurg 121(1):195–209 Hundepool CA, Nijhuis TH, Mohseny B et al (2014) The effect of stem cells in bridging peripheral nerve defects: a meta-analysis. J Neurosurg 121(1):195–209
3.
go back to reference Khouri RK, Rigotti G, Khouri RK Jr et al (2015) Tissue-engineered breast reconstruction with Brava-assisted fat grafting: a 7-year, 488-patient, multicenter experience. Plast Reconstr Surg 135(3):643–658CrossRefPubMed Khouri RK, Rigotti G, Khouri RK Jr et al (2015) Tissue-engineered breast reconstruction with Brava-assisted fat grafting: a 7-year, 488-patient, multicenter experience. Plast Reconstr Surg 135(3):643–658CrossRefPubMed
4.
go back to reference Klinger M, Marazzi M, Vigo D et al (2008) Fat injection for cases of severe burn outcomes: a new perspective of scar remodeling and reduction. Aesthetic Plast Surg 32(3):465–469 Klinger M, Marazzi M, Vigo D et al (2008) Fat injection for cases of severe burn outcomes: a new perspective of scar remodeling and reduction. Aesthetic Plast Surg 32(3):465–469
5.
go back to reference Mazzola RF, Mazzola IC (2015) History of fat grafting: from ram fat to stem cells. Clin Plast Surg 42(2):147–153CrossRefPubMed Mazzola RF, Mazzola IC (2015) History of fat grafting: from ram fat to stem cells. Clin Plast Surg 42(2):147–153CrossRefPubMed
7.
go back to reference Zack-Williams SD, Butler PE, Kalaskar DM (2015) Current progress in use of adipose derived stem cells in peripheral nerve regeneration. World J Stem Cells 7(1):51–64CrossRefPubMedPubMedCentral Zack-Williams SD, Butler PE, Kalaskar DM (2015) Current progress in use of adipose derived stem cells in peripheral nerve regeneration. World J Stem Cells 7(1):51–64CrossRefPubMedPubMedCentral
8.
go back to reference di Summa PG, Kingham PJ, Raffoul W et al (2010) Adipose-derived stem cells enhance peripheral nerve regeneration. J Plastic Reconstr Aesthet Surg 63(9):1544–1552 di Summa PG, Kingham PJ, Raffoul W et al (2010) Adipose-derived stem cells enhance peripheral nerve regeneration. J Plastic Reconstr Aesthet Surg 63(9):1544–1552
9.
go back to reference Lopatina T, Kalinina N, Karagyaur M et al (2011) Adipose-derived stem cells stimulate regeneration of peripheral nerves: BDNF secreted by these cells promotes nerve healing and axon growth de novo. PLoS One 6(3):e17899CrossRefPubMedPubMedCentral Lopatina T, Kalinina N, Karagyaur M et al (2011) Adipose-derived stem cells stimulate regeneration of peripheral nerves: BDNF secreted by these cells promotes nerve healing and axon growth de novo. PLoS One 6(3):e17899CrossRefPubMedPubMedCentral
10.
go back to reference Sowa J, Kishida T, Imura T et al (2016) Adipose-derived stem cells promote peripheral nerve regeneration in vivo without differentiation into Swann-like lineage. J Plast Reconstr Surg 137(2):318e–330eCrossRef Sowa J, Kishida T, Imura T et al (2016) Adipose-derived stem cells promote peripheral nerve regeneration in vivo without differentiation into Swann-like lineage. J Plast Reconstr Surg 137(2):318e–330eCrossRef
Metadata
Title
Lipofilling may induce nerve regeneration after previous traumatic injury: a clinical case with remarkable outcome
Authors
Geraldine L. Nanninga
Tim H. Nijhuis
Rutger M. Schols
Sjoerd B. Paulusma
J. Henk Coert
Jean Bart Jaquet
Publication date
01-10-2016
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Plastic Surgery / Issue 5/2016
Print ISSN: 0930-343X
Electronic ISSN: 1435-0130
DOI
https://doi.org/10.1007/s00238-016-1193-7

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