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01-02-2019 | Short Report

There is an exception to every rule—T2-FLAIR mismatch sign in gliomas

Authors: Derek R. Johnson, Timothy J. Kaufmann, Sohil H. Patel, Andrew S. Chi, Matija Snuderl, Rajan Jain

Published in: Neuroradiology | Issue 2/2019

Abstract

The T2-FLAIR mismatch sign, in which a low-grade glioma is hyperintense on T2-weighted MR and centrally hypointense on T2-weighted FLAIR MR, has been reported as 100% specific for IDH-mutant astrocytomas in several series. We report several cases of “false positive” T2-FLAIR mismatch sign occurring outside the context of IDH-mutant astrocytomas, predominantly in children or young adults with pediatric-type gliomas. These results suggest caution in the interpretation of the T2-FLAIR mismatch sign in the pediatric glioma population.

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Title: There is an exception to every rule—T2-FLAIR mismatch sign in gliomas
Authors: Derek R. Johnson
Timothy J. Kaufmann
Sohil H. Patel
Andrew S. Chi
Matija Snuderl
Rajan Jain
Publication date: 01-02-2019
Publisher: Springer Berlin Heidelberg
Published in: Neuroradiology / Issue 2/2019
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-018-2148-4

At a glance: The STEP trials

Springer Medicine

There is an exception to every rule—T2-FLAIR mismatch sign in gliomas

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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