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Neuroradiology

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01-12-2018 | Functional Neuroradiology

Abnormal changes in functional connectivity between the amygdala and frontal regions are associated with depression in Alzheimer’s disease

Authors: Zhongwei Guo, Xiaozheng Liu, Songquan Xu, Hongtao Hou, Xingli Chen, Zhenzhong Zhang, Wei Chen

Published in: Neuroradiology | Issue 12/2018

Abstract

Purpose

The aim of the present study was to investigate the functional connectivity (FC) of Alzheimer’s disease patients with depression (D-AD) based on an amygdalar seed using resting-state functional magnetic resonance imaging (rs-fMRI).

Methods

Twenty-one non-depressed AD (nD-AD) patients and 21 D-AD patients underwent rs-fMRI. The Hamilton Depression Rating Scale and Neuropsychiatric Inventory were used to evaluate the severity of depression. The amygdala was used as the seed for FC analysis. The FC differences between the two groups were evaluated by two-sample t tests, and the correlation of FC changes with depressive severity was analyzed by Pearson correlational analysis.

Results

Compared with the nD-AD patients, D-AD patients had increased FC values between the amygdala and orbitofrontal cortex and decreased FC values among the amygdala, medial prefrontal cortex, and inferior frontal gyrus.

Conclusion

These data suggest that abnormal amygdala-prefrontal FC may be an important characteristic of AD patients with depression.

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Title: Abnormal changes in functional connectivity between the amygdala and frontal regions are associated with depression in Alzheimer’s disease
Authors: Zhongwei Guo
Xiaozheng Liu
Songquan Xu
Hongtao Hou
Xingli Chen
Zhenzhong Zhang
Wei Chen
Publication date: 01-12-2018
Publisher: Springer Berlin Heidelberg
Published in: Neuroradiology / Issue 12/2018
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-018-2100-7

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abnormal changes in functional connectivity between the amygdala and frontal regions are associated with depression in Alzheimer’s disease

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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