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01-05-2018 | Diagnostic Neuroradiology

Roles of the apparent diffusion coefficient and tumor volume in predicting tumor grade in patients with choroid plexus tumors

Authors: Tomoaki Sasaki, John Kim, Toshio Moritani, Aristides A. Capizzano, Shawn P. Sato, Yutaka Sato, Patricia Kirby, Shunta Ishitoya, Akiko Oya, Masahiro Toda, Sayaka Yuzawa, Koji Takahashi

Published in: Neuroradiology | Issue 5/2018

Abstract

Purpose

To explore the utility of the apparent diffusion coefficient (ADC) and tumor volume to predict histological grade and prognosis in patients with choroid plexus tumors.

Methods

ADC and tumor volumes were retrospectively evaluated in 25 patients with choroid plexus papilloma (CPP; WHO grade 1 [n = 13]), atypical CPP (aCPP; grade 2 [n = 8]), or choroid plexus carcinoma (grade 3 [n = 4]) The prognostic roles of ADC and tumor volume were assessed.

Results

There were significant differences in mean and minimum ADC values, and tumor volume among the WHO grades (p = 0.033, p = 0.044, and p = 0.014, respectively). Receiver-operating characteristic analysis revealed a mean cutoff ADC value ≤ 1.397 × 10⁻³ mm²/s for aCPP (sensitivity = 0.667, specificity = 0.923). Multiple linear regression analysis demonstrated that both mean ADC (β = − 0.455, p = 0.005) and tumor volume (β = 0.513, p = 0.002) were correlated with WHO grade (adjusted R² = 0.520, p = 0.005). Kaplan-Meier curve analysis identified poorer survival in patients with WHO grade 2 and 3 tumors than in those with WHO grade 1 disease (p = 0.049 and p = 0.012, respectively). A mean ADC ≤ 1.397 × 10⁻³ mm²/s (p = 0.001) and tumor volume 21.05 ml (p = 0.031) predicted significantly poorer survival.

Conclusion

Mean ADC and tumor volume were correlated with WHO grade of choroid plexus tumors. A lower ADC value and a larger tumor volume predicted a poorer prognosis.

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Title: Roles of the apparent diffusion coefficient and tumor volume in predicting tumor grade in patients with choroid plexus tumors
Authors: Tomoaki Sasaki
John Kim
Toshio Moritani
Aristides A. Capizzano
Shawn P. Sato
Yutaka Sato
Patricia Kirby
Shunta Ishitoya
Akiko Oya
Masahiro Toda
Sayaka Yuzawa
Koji Takahashi
Publication date: 01-05-2018
Publisher: Springer Berlin Heidelberg
Published in: Neuroradiology / Issue 5/2018
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-018-2008-2

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Roles of the apparent diffusion coefficient and tumor volume in predicting tumor grade in patients with choroid plexus tumors

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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