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01-05-2015 | Diagnostic Neuroradiology

Diffusion tensor MR imaging of white matter integrity in HIV-positive patients with planning deficit

Authors: Diogo Goulart Corrêa, Nicolle Zimmermann, Thomas M. Doring, Nina Ventura Wilner, Sarah C. B. Leite, Rafael Ferracini Cabral, Rochele Paz Fonseca, Paulo R. V. Bahia, Emerson Leandro Gasparetto

Published in: Neuroradiology | Issue 5/2015

Abstract

Introduction

The aim of this study was to evaluate whether normal controls and human immunodeficiency virus (HIV) patients with and without planning deficits differ on white matter integrity.

Methods

A total of 34 HIV-positive patients with planning deficits were compared with 13 HIV-positive patients without planning deficits and 19 gender-, age-, and education-matched control subjects. Diffusion tensor imaging (DTI) was performed along 30 noncolinear directions in a 1.5-T scanner. For tract-based spatial statistics analysis, a white matter skeleton was created, and a permutation-based inference with 5000 permutations with a threshold of p < 0.05 was used to identify abnormalities in fractional anisotropy (FA). The median, radial, and axial diffusivities were also projected onto the mean FA skeleton.

Results

Compared with controls, HIV-positive patients with planning deficits had decreased FA in bilateral anterior thalamic radiations, bilateral inferior fronto-occiptal fasciculi, genu and splenium of the corpus callosum, bilateral superior longitudinal fascicule, and bilateral uncinate fasciculi. Compared to HIV-positive patients without planning deficits, patients with planning deficits had decreased FA in bilateral anterior thalamic radiations, bilateral inferior fronto-occiptal fasciculi, genu of the corpus callosum, bilateral superior longitudinal fascicule, and right uncinate fascicule.

Conclusion

DTI can detect extensive white matter abnormalities in the normal-appearing white matter of HIV-positive patients with planning deficits compared with controls and HIV-positive patients without planning deficits.

Karampekios S, John Hesselink J (2005) Cerebral infections. Eur Radiol 15:485–493CrossRefPubMed

Sundgren PC, Dong Q, Gómez-Hassan D, Mukherji SK, Maly P, Welsh R (2004) Diffusion tensor imaging of the brain: review of clinical applications. Neuroradiology 46(5):339–350CrossRefPubMed

Thurnher MM, Castillo M, Stadler A, Rieger A, Schmid B, Sundgren PC (2005) Diffusion-tensor MR imaging of the brain in human immunodeficiency virus-positive patients. AJNR Am J Neuroradiol 26:2275–2281PubMed

Filippi CG, Ulug AM, Ryan E, Ferrando SJ, van Gorp W (2001) Diffusion tensor imaging of HIV patients and normal-appearing white matter on MR images of the brain. AJNR Am J Neuroradiol 22:277–83PubMed

Wu Y, Storey P, Cohen BA, Epstein LG, Edelman RR, Ragin AB (2006) Diffusion alterations in corpus callosum of patients with HIV. AJNR Am J Neuroradiol 27:656–60PubMedCentralPubMed

Pomara N, Crandall DT, Choi SJ, Johnson G, Lim KO (2001) White matter abnormalities in HIV-1 infection: a diffusion tensor imaging study. Psychiatry Res 106(1):15–24CrossRefPubMed

Ragin AB, Storey P, Cohen BA, Epstein LG, Edelman RR (2004) Whole brain diffusion tensor imaging in HIV-associated cognitive impairment. AJNR Am J Neuroradiol 25(2):195–200PubMedCentralPubMed

Ragin AB, Wu Y, Storey P, Cohen BA, Edelman RR, Epstein LG (2005) Diffusion tensor imaging of subcortical brain injury in patients infected with human immunodeficiency virus. J Neurovirol 11:292–298CrossRefPubMedCentralPubMed

Leite SC, Corrêa DG, Doring TM et al (2013) Diffusion tensor MRI evaluation of the corona radiata, cingulate gyri, and corpus callosum in HIV patients. J Magn Reson Imaging 38(6):1488–1493CrossRefPubMed

10.

Gongvatana A, Schweinsburg BC, Taylor MJ et al (2009) White matter tract injury and cognitive impairment in human immunodeficiency virus-infected individuals. J Neurovirol 15(2):187–95CrossRefPubMedCentralPubMed

11.

Chen Y, An H, Zun H et al (2009) White matter abnormalities revealed by diffusion tensor imaging in non-demented and demented HIV+ patients. NeuroImage 47:1154–1162CrossRefPubMed

12.

Stubbe-Dräger B, Deppe M, Mohammadi S et al (2012) Early microstructural white matter changes in patients with HIV: a diffusion tensor imaging study. BMC Neurol 12:23CrossRef

13.

Antinori A, Arendt G, Becker JT et al (2007) Updated research nosology for HIV-associated neurocognitive disorders. Neurology 69:1789–1799CrossRefPubMed

14.

Elliott R (2003) Executive functions and their disorders. Br Med Bull 65:49–59CrossRefPubMed

15.

Jurado MB, Rosselli M (2007) The elusive nature of executive functions: a review of our current understanding. Neuropsychol Rev 17:213–233CrossRefPubMed

16.

Cattie JE, Doyle K, Weber E et al (2012) Planning deficits in HIV-associated neurocognitive disorders: component processes, cognitive correlates, and implications for everyday functioning. J Clin Exp Neuropsychol 34(9):906–918CrossRefPubMedCentralPubMed

17.

Reger M, Welsh R, Razani J, Martin DJ, Boone KB (2002) A meta-analysis of the neuropsychological sequelae of HIV infection. J Int Neuropsychol Soc 8:410–424CrossRefPubMed

18.

Dawes S, Suarez P, Casey CY, Cherner M, Marcotte TD, Letendre S (2008) Variable patterns of neuropsychological performance in HIV-1 infection. J Clin Exp Neuropsychol 30:613–626CrossRefPubMedCentralPubMed

19.

Woods SP, Moore DJ, Weber E, Grant I (2009) Cognitive neuropsychology of HIV-associated neurocognitive disorders. Neuropsychol Rev 19:152–168CrossRefPubMedCentralPubMed

20.

Heaton RK, Chelune GJ, Talley JL, Kay GG, Curtiss G (1993) Wisconsin card sorting test manual (revised and expanded). Psychological Assessment Resources, Odessa

21.

Cunha JA, Trentini CM, Argimon I, Oliveira MS, Werlang BG, Prieb RGG (2005) Adaptação e padronização brasileira do Manual do Teste Wisconsin de Classificação de Cartas. Casa do Psicólogo

22.

Kavé G, Heled E, Vakil E, Agranov E (2011) Which verbal fluency measure is most useful in demonstrating executive deficits after traumatic brain injury? J Clin Exp Neuropsychol 33(3):358–365CrossRefPubMed

23.

Gauthier L, Dehaut F, Joanette Y (1989) The bells test: a quantitative and qualitative test for visual neglect. J Int Neuropsychol Soc 11:49–54

24.

Fonseca RP, Oliveira C, Gindri G, Zimmermann N, Reppold C (2010) Teste Hayling: um instrumento de avaliação de componentes das funções executivas. In: Hutz C (ed) Avaliação psicológica e neuropsicológica de crianças e adolescente. Casa do Psicólogo, São Paulo, pp 337–364

25.

War Department Adjutant General′s Office (1944) Army individual test battery: manual of directions and scoring. Edited by: Washington DC: War Department Adjutant General′s Office

26.

Wechsler D (1997) Wechsler adult intelligence scale—III. The Psychological Corporation, San Antonio

27.

Salgado JV, Malloy-Diniz LF, Abrantes SSC et al (2011) Applicability of the rey auditory-verbal learning test to an adult sample in Brazil. Rev Bras Psiquiatr 33:234–237CrossRefPubMed

28.

Fonseca RP, Salles JF, Parente MAMP (2009) Instrumento de avaliação neuropsicológica breve NEUPSILIN. Vetor, São Paulo

29.

Fonseca RP, Parente MAMP, Côté H, Ska B, Joanette Y (2008) Bateria montreal de avaliação da comunicação—Bateria MAC. Pró-Fono, São Paulo

30.

Smith SM, Jenkinson M, Woolrich MW et al (2004) Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage 23:208–219CrossRef

31.

Smith SM, Jenkinson M, Johansen-Berg H et al (2006) Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data. Neuroimage 31:1487–1505CrossRefPubMed

32.

Kramer JH, Mungas D, Possin KL et al (2014) NIH EXAMINER: conceptualization and development of an executive function battery. J Int Neuropsychol Soc 20:11–19CrossRefPubMed

33.

Gouveia PAR, Brucki SMD, Malheiros SMF, Bueno OFA (2007) Disorders in planning and strategy application in frontal lobe lesion patients. Brain Cogn 63:240–246CrossRefPubMed

34.

Alexander MP, Stuss DT, Picton T, Shallice T, Gillingham S (2007) Regional frontal injuries cause distinct impairments in cognitive control. Neurology 68:1515–1523CrossRefPubMed

35.

Grafman J (1995) Similarities and distinctions among current models of prefrontal cortical functions. Ann N Y Acad Sci 769:337–368CrossRefPubMed

36.

Sun SW, Liang HF, Trinkaus K, Cross AH, Armstrong RC, Song SK (2006) Noninvasive detection of cuprizone induced axonal damage and demyelination in the mouse corpus callosum. Magn Reson Med 55:302–308CrossRefPubMed

37.

Smith AB, Smirniotopoulos JG, Rushing EJ (2008) From the archives of the AFIP—central nervous system infections associated with human immunodeficiency virus infection: radiologic–pathologic correlation. RadioGraphics 28:2033–2058CrossRefPubMed

Title: Diffusion tensor MR imaging of white matter integrity in HIV-positive patients with planning deficit
Authors: Diogo Goulart Corrêa
Nicolle Zimmermann
Thomas M. Doring
Nina Ventura Wilner
Sarah C. B. Leite
Rafael Ferracini Cabral
Rochele Paz Fonseca
Paulo R. V. Bahia
Emerson Leandro Gasparetto
Publication date: 01-05-2015
Publisher: Springer Berlin Heidelberg
Published in: Neuroradiology / Issue 5/2015
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-015-1489-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Diffusion tensor MR imaging of white matter integrity in HIV-positive patients with planning deficit

Abstract

Introduction

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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