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Neuroradiology

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01-07-2013 | Diagnostic Neuroradiology

Detection of irreversible changes in susceptibility-weighted images after whole-brain irradiation of children

Authors: S. Peters, R. Pahl, A. Claviez, O. Jansen

Published in: Neuroradiology | Issue 7/2013

Abstract

Introduction

Whole-brain irradiation is part of the therapy protocol for patients with medulloblastomas. Side effects and complications of radiation can be detected by follow-up magnetic resonance imaging (MRI). Susceptibility-weighted images (SWI) can detect even very small amounts of residual blood that cannot be shown with conventional MRI. The purpose of this study was to determine when and where SWI lesions appear after whole-brain irradiation.

Methods

MRI follow-up of seven patients with medulloblastoma who were treated with whole-brain irradiation were analyzed retrospectively. SWI were part of the initial and follow-up MRI protocol. De novo SWI lesions, localization, and development over time were documented.

Results

At time of irradiation, mean age of the patients was 13 years (±4 years). Earliest SWI lesions were detected 4 months after radiation treatment. In all patients, SWI lesions accumulated over time, although the individual number of SWI lesions varied. No specific dissemination of SWI lesions was observed.

Conclusion

Whole-brain irradiation can cause relatively early dot-like SWI lesions. The lesions are irreversible and accumulate over time. Histopathological correlation and clinical impact of these SWI lesions should be investigated.

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Title: Detection of irreversible changes in susceptibility-weighted images after whole-brain irradiation of children
Authors: S. Peters
R. Pahl
A. Claviez
O. Jansen
Publication date: 01-07-2013
Publisher: Springer Berlin Heidelberg
Published in: Neuroradiology / Issue 7/2013
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-013-1185-2

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Detection of irreversible changes in susceptibility-weighted images after whole-brain irradiation of children

Abstract

Introduction

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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