Skip to main content
Top
Published in: Neuroradiology 1/2013

01-01-2013 | Interventional Neuroradiology

Is general anaesthesia preferable to conscious sedation in the treatment of acute ischaemic stroke with intra-arterial mechanical thrombectomy? A review of the literature

Authors: N. John, P. Mitchell, R. Dowling, B. Yan

Published in: Neuroradiology | Issue 1/2013

Login to get access

Abstract

Introduction

Intra-arterial mechanical thrombectomy (IAMT) is an endovascular technique that allows for the acute retrieval of intravascular thrombi and is increasingly being used for the treatment of acute ischaemic stroke (AIS). There are currently two anaesthetic options during IAMT: general anaesthesia (GA) and conscious sedation (CS). The decision to use GA versus CS is the source of controversy, as it requires careful balance between patient pain, movement and airway protection whilst minimising time delay and haemodynamic fluctuations. This review examines and summarises the evidence for the use of GA versus CS in the treatment of AIS by IAMT.

Methods

Studies were identified using systematic bibliographic searches. The five applicable studies were analysed with reference to overall outcomes and the key parameters that govern the decision to use GA or CS. The key parameters included the impact of GA and CS on pain, complication rates, time delays, airway protection and haemodynamic stability.

Results

Several retrospective analyses have shown that the use of GA is associated with adverse outcomes.

Conclusion

Intra-arterial mechanical thrombectomy under general anaesthesia is associated with poor outcomes in observational studies. It is reasonable to offer conscious sedation as the preferred option where adverse patient factors such as agitation are lacking.
Literature
1.
go back to reference NINDS rt-PA Stroke Study Group (1995) Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 333:1581–1587CrossRef NINDS rt-PA Stroke Study Group (1995) Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 333:1581–1587CrossRef
2.
go back to reference Hacke W, Kaste M, Fieschi C et al (1995) Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke: The European Cooperative Acute Stroke Study (ECASS). J Am Med Assoc 274:1017–1025CrossRef Hacke W, Kaste M, Fieschi C et al (1995) Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke: The European Cooperative Acute Stroke Study (ECASS). J Am Med Assoc 274:1017–1025CrossRef
3.
go back to reference Hacke W, Kaste M, Fieschi C et al (1998) Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II): Second European-Australasian Acute Stroke Study Investigators. Lancet 352:1245–1511PubMedCrossRef Hacke W, Kaste M, Fieschi C et al (1998) Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II): Second European-Australasian Acute Stroke Study Investigators. Lancet 352:1245–1511PubMedCrossRef
4.
go back to reference Hacke W, Kaste M, Bluhmki E et al (2008) Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 359:1317–1329PubMedCrossRef Hacke W, Kaste M, Bluhmki E et al (2008) Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 359:1317–1329PubMedCrossRef
5.
go back to reference Mazighi M, Serfaty JM, Labreuche J et al (2009) Comparison of intravenous alteplase with a combined intravenous-endovascular approach in patients with stroke and confirmed arterial occlusion (RECANALISE study): a prospective cohort study. Lancet Neurol 8:802–809PubMedCrossRef Mazighi M, Serfaty JM, Labreuche J et al (2009) Comparison of intravenous alteplase with a combined intravenous-endovascular approach in patients with stroke and confirmed arterial occlusion (RECANALISE study): a prospective cohort study. Lancet Neurol 8:802–809PubMedCrossRef
6.
go back to reference Molina CA, Alexandrov AV, Demchuk AM, Saqqur M, Uchino K, Alvarez-Sabin J (2004) Improving the predictive accuracy of recanalization on stroke outcome in patients treated with tissue plasminogen activator. Stroke 35:151–156PubMedCrossRef Molina CA, Alexandrov AV, Demchuk AM, Saqqur M, Uchino K, Alvarez-Sabin J (2004) Improving the predictive accuracy of recanalization on stroke outcome in patients treated with tissue plasminogen activator. Stroke 35:151–156PubMedCrossRef
7.
go back to reference Saqqur M, Uchino K, Demchuk AM et al (2007) Site of arterial occlusion identified by transcranial Doppler predicts the response to intravenous thrombolysis for stroke. Stroke 38:948–954PubMedCrossRef Saqqur M, Uchino K, Demchuk AM et al (2007) Site of arterial occlusion identified by transcranial Doppler predicts the response to intravenous thrombolysis for stroke. Stroke 38:948–954PubMedCrossRef
8.
go back to reference Del Zoppo GJ, Poeck K, Pessin MS et al (1992) Recombinant tissue plasminogen activator in acute thrombotic and embolic stroke. Ann Neurol 32:78–86PubMedCrossRef Del Zoppo GJ, Poeck K, Pessin MS et al (1992) Recombinant tissue plasminogen activator in acute thrombotic and embolic stroke. Ann Neurol 32:78–86PubMedCrossRef
9.
go back to reference IMS Study Investigators (2004) Combined intravenous and intra-arterial recanalization for acute ischemic stroke: the Interventional Management of Stroke Study. Stroke 35:904–911CrossRef IMS Study Investigators (2004) Combined intravenous and intra-arterial recanalization for acute ischemic stroke: the Interventional Management of Stroke Study. Stroke 35:904–911CrossRef
10.
go back to reference Lewandowski CA, Frankel M, Tomsick TA et al (1999) Combined intravenous and intra-arterial r-TPA versus intra-arterial therapy of acute ischemic stroke: Emergency Management of Stroke (EMS) Bridging Trial. Stroke 30:2598–2605PubMedCrossRef Lewandowski CA, Frankel M, Tomsick TA et al (1999) Combined intravenous and intra-arterial r-TPA versus intra-arterial therapy of acute ischemic stroke: Emergency Management of Stroke (EMS) Bridging Trial. Stroke 30:2598–2605PubMedCrossRef
11.
go back to reference Del Zoppo GJ, Higashida RT, Furlan AJ, Pessin MS, Rowley HA, Gent M (1998) PROACT: a phase II randomized trial of recombinant pro-urokinase by direct arterial delivery in acute middle cerebral artery stroke—PROACT Investigators. Prolyse in Acute Cerebral Thromboembolism. Stroke 29:4–11PubMedCrossRef Del Zoppo GJ, Higashida RT, Furlan AJ, Pessin MS, Rowley HA, Gent M (1998) PROACT: a phase II randomized trial of recombinant pro-urokinase by direct arterial delivery in acute middle cerebral artery stroke—PROACT Investigators. Prolyse in Acute Cerebral Thromboembolism. Stroke 29:4–11PubMedCrossRef
12.
go back to reference Furlan A, Higashida R, Wechsler L et al (1999) Intra-arterial prourokinase for acute ischemic stroke: The PROACT II study—a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism. J Am Med Assoc 282:2003–2011CrossRef Furlan A, Higashida R, Wechsler L et al (1999) Intra-arterial prourokinase for acute ischemic stroke: The PROACT II study—a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism. J Am Med Assoc 282:2003–2011CrossRef
13.
go back to reference Gobin YP, Starkman S, Duckwiler GP et al (2004) Merci 1: a phase 1 study of mechanical embolus removal in cerebral ischemia. Stroke 35:2848–2854PubMedCrossRef Gobin YP, Starkman S, Duckwiler GP et al (2004) Merci 1: a phase 1 study of mechanical embolus removal in cerebral ischemia. Stroke 35:2848–2854PubMedCrossRef
14.
go back to reference Smith W, Sung G, Saver J et al (2008) Mechanical thrombectomy for acute ischemic stroke: final results of the Multi Merci trial. Stroke 39:1205–1212PubMedCrossRef Smith W, Sung G, Saver J et al (2008) Mechanical thrombectomy for acute ischemic stroke: final results of the Multi Merci trial. Stroke 39:1205–1212PubMedCrossRef
15.
go back to reference Miteff F, Faulder KC, Goh AC, Steinfort BS, Sue C, Harrington TJ (2011) Mechanical thrombectomy with a self-expanding retrievable intracranial stent (Solitaire AB): experience in 26 patients with acute cerebral artery occlusion. Am J Neuroradiol 32:1078–1081PubMedCrossRef Miteff F, Faulder KC, Goh AC, Steinfort BS, Sue C, Harrington TJ (2011) Mechanical thrombectomy with a self-expanding retrievable intracranial stent (Solitaire AB): experience in 26 patients with acute cerebral artery occlusion. Am J Neuroradiol 32:1078–1081PubMedCrossRef
16.
go back to reference Varma MK, Price K, Jayakrishnan V, Manickam B, Kessell G (2007) Anaesthetic considerations for interventional neuroradiology. Br J Anaesth 99(1):75–85PubMedCrossRef Varma MK, Price K, Jayakrishnan V, Manickam B, Kessell G (2007) Anaesthetic considerations for interventional neuroradiology. Br J Anaesth 99(1):75–85PubMedCrossRef
17.
go back to reference Adams H, Zoppo GD, Alberts M et al (2007) Guidelines for the early management of adults with ischemic stroke. Stroke 38:1655–1711PubMedCrossRef Adams H, Zoppo GD, Alberts M et al (2007) Guidelines for the early management of adults with ischemic stroke. Stroke 38:1655–1711PubMedCrossRef
18.
go back to reference McDonagh Dm Olson D, Kalia J, Gupta R, Abou-Chebl A, Zaidat OO (2010) Anaesthesia and sedation practices among neurointerventionalists during acute ischaemic stroke endovascular therapy. Front Neurol 1:118 McDonagh Dm Olson D, Kalia J, Gupta R, Abou-Chebl A, Zaidat OO (2010) Anaesthesia and sedation practices among neurointerventionalists during acute ischaemic stroke endovascular therapy. Front Neurol 1:118
19.
go back to reference Abou-Chebl A, Lin R, Hussain MS et al (2010) Conscious sedation versus general anesthesia during endovascular therapy for acute anterior circulation stroke: preliminary results from a retrospective multicenter study. Stroke 41:1175–1179PubMedCrossRef Abou-Chebl A, Lin R, Hussain MS et al (2010) Conscious sedation versus general anesthesia during endovascular therapy for acute anterior circulation stroke: preliminary results from a retrospective multicenter study. Stroke 41:1175–1179PubMedCrossRef
20.
go back to reference Brekenheld C, Mattle H, Schroth G (2010) General is better than local anesthesia during endovascular procedures. Stroke 41:2716–2717CrossRef Brekenheld C, Mattle H, Schroth G (2010) General is better than local anesthesia during endovascular procedures. Stroke 41:2716–2717CrossRef
21.
go back to reference Jumaa M, Zhang F, Ruiz-Ares G, Gelzinis T et al (2010) Comparison of safety and clinical and radiographic outcomes in endovascular acute stroke therapy for proximal middle cerebral artery occlusion with intubation and general anesthesia versus the non-intubated state. Stroke 41:1180–1184PubMedCrossRef Jumaa M, Zhang F, Ruiz-Ares G, Gelzinis T et al (2010) Comparison of safety and clinical and radiographic outcomes in endovascular acute stroke therapy for proximal middle cerebral artery occlusion with intubation and general anesthesia versus the non-intubated state. Stroke 41:1180–1184PubMedCrossRef
22.
go back to reference Davis MJ, Menon BK, Baghirzada LB, Campos-Herrera CR, Goyal M, Hill M, Archer D (2012) Anesthetic management and outcome in patients during endovascular therapy for acute stroke. Anesthesiology 116:396–405PubMedCrossRef Davis MJ, Menon BK, Baghirzada LB, Campos-Herrera CR, Goyal M, Hill M, Archer D (2012) Anesthetic management and outcome in patients during endovascular therapy for acute stroke. Anesthesiology 116:396–405PubMedCrossRef
23.
24.
go back to reference TIMI Study Group (1985) The thrombolysis in myocardial infarction (TIMI) trial: phase I findings. N Engl J Med 312:932–936 TIMI Study Group (1985) The thrombolysis in myocardial infarction (TIMI) trial: phase I findings. N Engl J Med 312:932–936
25.
go back to reference Abou-Chebl A, Krieger DW, Bajzer CT, Yadav JS (2006) Intracranial angioplasty and stenting in the awake patient. J Neuroimaging 16:216–223PubMedCrossRef Abou-Chebl A, Krieger DW, Bajzer CT, Yadav JS (2006) Intracranial angioplasty and stenting in the awake patient. J Neuroimaging 16:216–223PubMedCrossRef
27.
go back to reference Smith WS, Sung G, Starkmann S et al (2005) Safety and efficacy of mechanical embolectomy in acute ischemic stroke: results of the MERCI trial. Stroke 36:1432–1438PubMedCrossRef Smith WS, Sung G, Starkmann S et al (2005) Safety and efficacy of mechanical embolectomy in acute ischemic stroke: results of the MERCI trial. Stroke 36:1432–1438PubMedCrossRef
28.
go back to reference Khatri P, Abruzzo T, Yeatts SD, Nichols C, Broderick JP, Tomsick TA (2009) Good clinical outcome after ischemic stroke with successful revascularization is time-dependent. Neurology 73(13):1066–1072PubMedCrossRef Khatri P, Abruzzo T, Yeatts SD, Nichols C, Broderick JP, Tomsick TA (2009) Good clinical outcome after ischemic stroke with successful revascularization is time-dependent. Neurology 73(13):1066–1072PubMedCrossRef
29.
go back to reference Young WL (2007) Anesthesia for endovascular neurosurgery and interventional neuroradiology. Anesthesiol Clin 25:391–412PubMedCrossRef Young WL (2007) Anesthesia for endovascular neurosurgery and interventional neuroradiology. Anesthesiol Clin 25:391–412PubMedCrossRef
30.
go back to reference Klinger RY, White WD, Hale B, Habib AS, Bennett-Guerrero E (2012) Hemodynamic impact of dexmedetomidine administration in 15,656 non-cardiac surgical cases. J Clin Anesth 24(3):212–220PubMedCrossRef Klinger RY, White WD, Hale B, Habib AS, Bennett-Guerrero E (2012) Hemodynamic impact of dexmedetomidine administration in 15,656 non-cardiac surgical cases. J Clin Anesth 24(3):212–220PubMedCrossRef
31.
go back to reference Anonymous (1999) Practice guidelines for preoperative fasting and the use of pharmacological agents to reduce the risk of pulmonary aspiration: application to healthy patients undergoing elective procedures: a report by the American Society of Anesthesiologist Task Force on Preoperative Fasting. Anesthesiology 90(3):896–905CrossRef Anonymous (1999) Practice guidelines for preoperative fasting and the use of pharmacological agents to reduce the risk of pulmonary aspiration: application to healthy patients undergoing elective procedures: a report by the American Society of Anesthesiologist Task Force on Preoperative Fasting. Anesthesiology 90(3):896–905CrossRef
32.
go back to reference Martino R, Foley N, Bhogal S, Diamant N, Speechley M, Teasell R (2005) Dysphagia after stroke: incidence, diagnosis, and pulmonary complications. Stroke 36:2756–2763PubMedCrossRef Martino R, Foley N, Bhogal S, Diamant N, Speechley M, Teasell R (2005) Dysphagia after stroke: incidence, diagnosis, and pulmonary complications. Stroke 36:2756–2763PubMedCrossRef
33.
go back to reference Rosenberg M, Weaver J (1991) General anesthesia. Anesth Prog 38:172–186PubMed Rosenberg M, Weaver J (1991) General anesthesia. Anesth Prog 38:172–186PubMed
34.
go back to reference Ginsberg MD, Pulsinelli WA (1994) The ischemic penumbra, injury thresholds, and the therapeutic window for acute stroke. Ann Neurol 36:557–565CrossRef Ginsberg MD, Pulsinelli WA (1994) The ischemic penumbra, injury thresholds, and the therapeutic window for acute stroke. Ann Neurol 36:557–565CrossRef
35.
go back to reference Stead LG, Gilmore RM, Vedula KC, Weaver AL, Decker WW, Brown RD Jr (2006) Impact of acute blood pressure variability on ischaemic stroke outcome. Neurology 66(12):1878–1881PubMedCrossRef Stead LG, Gilmore RM, Vedula KC, Weaver AL, Decker WW, Brown RD Jr (2006) Impact of acute blood pressure variability on ischaemic stroke outcome. Neurology 66(12):1878–1881PubMedCrossRef
36.
go back to reference Reich DL, Hossain S, Krol M, Baez B, Patel P, Bernstein A, Bodian CA (2005) Predictors of hypotension after induction of general anaesthesia. Anesth Analg 101(3):622–628PubMedCrossRef Reich DL, Hossain S, Krol M, Baez B, Patel P, Bernstein A, Bodian CA (2005) Predictors of hypotension after induction of general anaesthesia. Anesth Analg 101(3):622–628PubMedCrossRef
37.
go back to reference Alexandrov AV, Sharma VK, Lao AY, Tsivgoulis G, Malkoff MD, Alexandrov AW (2007) Reversed Robin Hood syndrome in acute ischemic stroke patients. Stroke 38:3045–3048PubMedCrossRef Alexandrov AV, Sharma VK, Lao AY, Tsivgoulis G, Malkoff MD, Alexandrov AW (2007) Reversed Robin Hood syndrome in acute ischemic stroke patients. Stroke 38:3045–3048PubMedCrossRef
38.
go back to reference Ahmed A (2007) Anaesthesia for interventional neuroradiology. J Ayub Med Coll Abbottabad 19(3):80–84PubMed Ahmed A (2007) Anaesthesia for interventional neuroradiology. J Ayub Med Coll Abbottabad 19(3):80–84PubMed
39.
go back to reference Manninen PH, Chan AS, Papworth D (1997) Conscious sedation for interventional neuroradiology: a comparison of midazolam and propofol infusion. Can J Anaesth 44(1):26–30PubMedCrossRef Manninen PH, Chan AS, Papworth D (1997) Conscious sedation for interventional neuroradiology: a comparison of midazolam and propofol infusion. Can J Anaesth 44(1):26–30PubMedCrossRef
Metadata
Title
Is general anaesthesia preferable to conscious sedation in the treatment of acute ischaemic stroke with intra-arterial mechanical thrombectomy? A review of the literature
Authors
N. John
P. Mitchell
R. Dowling
B. Yan
Publication date
01-01-2013
Publisher
Springer-Verlag
Published in
Neuroradiology / Issue 1/2013
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI
https://doi.org/10.1007/s00234-012-1084-y

Other articles of this Issue 1/2013

Neuroradiology 1/2013 Go to the issue

ACKNOWLEDGEMENT TO REFEREES

Reviewers January 2012–November 2012