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01-11-2012 | Diagnostic Neuroradiology

Olfactory bulb volume in patients with idiopathic normal pressure hydrocephalus

Authors: Dino Podlesek, Mario Leimert, Benno Schuster, Johannes Gerber, Gabriele Schackert, Matthias Kirsch, Thomas Hummel

Published in: Neuroradiology | Issue 11/2012

Abstract

Introduction

An important pathological feature of idiopathic normal pressure hydrocephalus (iNPH) is a dysfunction of cerebrospinal fluid dynamics. Considering the delicate olfactory structures it appears possible that the olfactory bulb (OB) is compromised by this disease. Reports on the anatomy of the olfactory bulb and smell function in patients with idiopathic normal pressure hydrocephalus are absent in the literature. The main purpose of the present study was to evaluate the olfactory bulb (OB) volume and smell function in iNPH.

Methods

The study comprised 17 patients with iNPH (seven women and ten men, mean age = 66 years); they were compared to a group of 24 healthy people (11 women and 13 men, mean age = 62 years). Comprehensive assessment of olfactory function was conducted with the "Sniffin’ Sticks" test kit. In an additional pilot study, in a small subgroup of eight patients, measurements were performed before and approximately 7 months after surgical treatment of the hydrocephalus.

Results

The OB volume in patients with iNPH was significantly smaller compared to healthy controls. In our small postoperative patient population (n = 8), there was no significant change of the OB volume.

Conclusion

In conclusion our results suggest that iNPH significantly affects OB volumes.

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Title: Olfactory bulb volume in patients with idiopathic normal pressure hydrocephalus
Authors: Dino Podlesek
Mario Leimert
Benno Schuster
Johannes Gerber
Gabriele Schackert
Matthias Kirsch
Thomas Hummel
Publication date: 01-11-2012
Publisher: Springer-Verlag
Published in: Neuroradiology / Issue 11/2012
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-012-1050-8

At a glance: The STEP trials

Springer Medicine

Olfactory bulb volume in patients with idiopathic normal pressure hydrocephalus

Abstract

Introduction

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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