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01-12-2011 | Diagnostic Neuroradiology

Diffusion tensor imaging of peripheral nerve in patients with chronic inflammatory demyelinating polyradiculoneuropathy: a feasibility study

Authors: Takako Kakuda, Hiroshi Fukuda, Keizo Tanitame, Miyuki Takasu, Shuji Date, Kazuhide Ochi, Tomohiko Ohshita, Tatsuo Kohriyama, Katsuhide Ito, Masayasu Matsumoto, Kazuo Awai

Published in: Neuroradiology | Issue 12/2011

Abstract

Introduction

The purpose of this study was to assess the clinical feasibility of diffusion tensor imaging (DTI) for the evaluation of peripheral nerves in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP).

Methods

Using a 3-T magnetic resonance imaging scanner, we obtained DTI scans of the tibial nerves of 10 CIDP patients and 10 sex- and age-matched healthy volunteers. We prepared fractional anisotropy (FA) maps, measured the FA values of tibial nerves, and compared these values in the two study groups. In nine patients, we also performed tibial nerve conduction studies and analyzed the correlation between the FA values and parameters of the nerve conduction study.

Results

The tibial nerve FA values in CIDP patients (median 0.401, range 0.312–0.510) were significantly lower than those in healthy volunteers (median 0.530, range 0.469–0.647) (Mann–Whitney test, p < 0.01). They were significantly correlated with the amplitude of action potential (Spearman correlation coefficient, p = 0.04, r = 0.86) but not with nerve conduction velocity (p = 0.79, r = 0.11).

Conclusion

Our preliminary data suggest that the noninvasive DTI assessment of peripheral nerves may provide useful information in patients with CIDP.

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Title: Diffusion tensor imaging of peripheral nerve in patients with chronic inflammatory demyelinating polyradiculoneuropathy: a feasibility study
Authors: Takako Kakuda
Hiroshi Fukuda
Keizo Tanitame
Miyuki Takasu
Shuji Date
Kazuhide Ochi
Tomohiko Ohshita
Tatsuo Kohriyama
Katsuhide Ito
Masayasu Matsumoto
Kazuo Awai
Publication date: 01-12-2011
Publisher: Springer-Verlag
Published in: Neuroradiology / Issue 12/2011
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-010-0833-z

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Diffusion tensor imaging of peripheral nerve in patients with chronic inflammatory demyelinating polyradiculoneuropathy: a feasibility study

Abstract

Introduction

Methods

Results

Conclusion

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Abstract

Introduction

Methods

Results

Conclusion

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