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01-11-2008 | Head and Neck Radiology

Distant metastases and synchronous second primary tumors in patients with newly diagnosed oropharyngeal and hypopharyngeal carcinomas: evaluation of ¹⁸F-FDG PET and extended-field multi-detector row CT

Authors: Shu-Hang Ng, Sheng-Chieh Chan, Chun-Ta Liao, Joseph Tung-Chieh Chang, Sheung-Fat Ko, Hung-Ming Wang, Shu-Chyn Chin, Chin-Yu Lin, Shiang-Fu Huang, Tzu-Chen Yen

Published in: Neuroradiology | Issue 11/2008

Abstract

Introduction

Patients with oropharyngeal or hypopharyngeal squamous cell carcinoma (SCC) have a high risk of having distant metastases or second primary tumors. We prospectively evaluate the clinical usefulness of ¹⁸F-fluoro-2-deoxyglucose positron emission tomography (¹⁸F-FDG PET), extended-field multi-detector computed tomography (MDCT), and their side-by-side visual correlation for the detection of distant malignancies in these two tumors at presentation.

Materials and methods

A total of 160 patients with SCC of the oropharynx (n = 74) or hypopharynx (n = 86) underwent ¹⁸F-FDG PET and extended-field MDCT to detect distant metastases or second primary tumors. Suspected lesions were investigated by means of biopsy, clinical, or imaging follow-up.

Results

Twenty-six (16.3%) of our 160 patients were found to have distant malignancy. Diagnostic yields of ¹⁸F-FDG PET and MDCT were 12.5% and 8.1%, respectively. The sensitivity of ¹⁸F-FDG PET for detection of distant malignancies was 1.5-fold higher than that of MDCT (76.9% vs. 50.0%, P = 0.039), while its specificity was slightly lower (94.0% vs. 97.8%, P = 0.125). Side-by-side visual correlation of MDCT and ¹⁸F-FDG PET improved the sensitivity and specificity up to 80.8% and 98.5%, respectively, leading to alteration of treatment in 13.1% of patients. A significant difference in survival rates between its positive and negative results was observed.

Conclusion

¹⁸F-FDG PET and extended-field MDCT had acceptable diagnostic yields for detection of distant malignancies in untreated oropharyngeal and hypopharyngeal SCC. ¹⁸F-FDG PET was 1.5-fold more sensitive than MDCT, but had more false-positive findings. Their visual correlation improved the diagnostic accuracy, treatment planning, and prognosis prediction.

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Title: Distant metastases and synchronous second primary tumors in patients with newly diagnosed oropharyngeal and hypopharyngeal carcinomas: evaluation of 18F-FDG PET and extended-field multi-detector row CT
Authors: Shu-Hang Ng
Sheng-Chieh Chan
Chun-Ta Liao
Joseph Tung-Chieh Chang
Sheung-Fat Ko
Hung-Ming Wang
Shu-Chyn Chin
Chin-Yu Lin
Shiang-Fu Huang
Tzu-Chen Yen
Publication date: 01-11-2008
Publisher: Springer-Verlag
Published in: Neuroradiology / Issue 11/2008
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-008-0426-2

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Distant metastases and synchronous second primary tumors in patients with newly diagnosed oropharyngeal and hypopharyngeal carcinomas: evaluation of ¹⁸F-FDG PET and extended-field multi-detector row CT

Abstract

Introduction

Materials and methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Introduction

Materials and methods

Results

Conclusion

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