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01-07-2005 | Paediatric Neuroradiology

Brain metabolite changes on proton magnetic resonance spectroscopy in children with poorly controlled type 1 diabetes mellitus

Authors: K. Sarac, A. Akinci, A. Alkan, M. Aslan, T. Baysal, C. Özcan

Published in: Neuroradiology | Issue 7/2005

Abstract

The metabolite changes in the brains of children with poorly controlled type 1 diabetes mellitus (DM) were investigated by proton magnetic resonance spectroscopy (MRS). A total of 30 subjects and 14 age-matched healthy volunteers underwent single-voxel MRS (TE: 136). The duration of disease, medication, presence of hypoglycaemia episodes and the level of haemoglobin A1C (HbA1C) in the patients were noted. Voxels were placed in the pons, left basal ganglion (LBG) and left posterior parietal white matter (PPWM). N-acetylaspartate (NAA)/creatinine (Cr) and choline (Cho)/Cr ratios were calculated. The average HbA1c level was 11.9±3.4 (8.2–19.4). The average number of keto-acidosis episodes was 1.9±2.2 (0–9) and the average number of daily insulin injections was 2.8±0.97 (2–4). MRS revealed lower NAA/Cr and Cho/Cr ratios in the pons and lower NAA/Cr ratio in the PPWM of patients with DM than in control subjects. No significant correlation was observed between the number of hypoglycaemia episodes and metabolite ratios. Metabolic abnormalities have been observed by MRS in the brain of poorly controlled type 1 DM children. These metabolic changes, in particular in the pons region, include a decrease in NAA, indicating neuronal loss or functional impairment, and likely explanations for a decrease in Cho may be dynamic changes in membrane lipids and/or decreased membrane turnover.

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Title: Brain metabolite changes on proton magnetic resonance spectroscopy in children with poorly controlled type 1 diabetes mellitus
Authors: K. Sarac
A. Akinci
A. Alkan
M. Aslan
T. Baysal
C. Özcan
Publication date: 01-07-2005
Publisher: Springer-Verlag
Published in: Neuroradiology / Issue 7/2005
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-005-1387-3

At a glance: The STEP trials

Springer Medicine

Brain metabolite changes on proton magnetic resonance spectroscopy in children with poorly controlled type 1 diabetes mellitus

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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