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Neuroradiology
Published in: Neuroradiology 3/2005

01-03-2005 | Paediatric Neuroradiology

Diffusion-weighted MR imaging and MR spectroscopy in glutaric aciduria type 1

Authors: K. K. Oguz, A Ozturk, A Cila

Published in: Neuroradiology | Issue 3/2005

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Abstract

Although conventional magnetic resonance imaging (MRI) findings of glutaric aciduria type 1 (GA-1) have been well established, diffusion weighted MR imaging (DWI) and proton MR spectroscopy (MRS) findings are limited. We report widespread restricted diffusion in the white matter and increased diffusion in bilateral putamen in a case of GA-1. The MRS showed decreased N-acetyl-aspartate (NAA)/creatine (Cr) ratio compared with a sex and age-matched control with no significant change in choline (Cho)/Cr ratio. The presence of the lactate peak reflecting disturbed mitochondrial functions in this disease has never been reported.
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Metadata
Title
Diffusion-weighted MR imaging and MR spectroscopy in glutaric aciduria type 1
Authors
K. K. Oguz
A Ozturk
A Cila
Publication date
01-03-2005
Publisher
Springer-Verlag
Published in
Neuroradiology / Issue 3/2005
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI
https://doi.org/10.1007/s00234-005-1350-3

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