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01-05-2012 | Research Article

Pain catastrophizing and cortical responses in amputees with varying levels of phantom limb pain: a high-density EEG brain-mapping study

Authors: Lene Vase, Line Lindhardt Egsgaard, Lone Nikolajsen, Peter Svensson, Troels Staehelin Jensen, Lars Arendt-Nielsen

Published in: Experimental Brain Research | Issue 3/2012

Abstract

Pain catastrophizing has been associated with phantom limb pain, but so far the cortical processes and the brain regions involved in this relationship have not been investigated. It was therefore tested whether catastrophizing was related to (1) spontaneous pain, (2) somatosensory activity and (3) cortical responses in phantom limb pain patients. The cortical responses were investigated via electroencephalography (EEG) as it has a high temporal resolution which may be ideal for investigating especially the attentional and hypervigilance aspect of catastrophizing to standardized acute stimuli. Eighteen upper limb amputees completed the pain catastrophizing scale. Patients’ spontaneous pain levels (worst and average pain, numerical rating scales) and thresholds to electrical stimulation (sensory detection and VRS2: intense but not painful) were determined. Non-painful electrical stimuli were applied to both the affected and non-affected arm, while high-resolution (128 channels) EEG signals were recorded. Catastrophizing accounted for significant amounts of the variance in relation to spontaneous pain, especially worst pain (64.1%), and it was significantly associated with thresholds. At the affected side, catastrophizing was significantly related to the power RMS of the N/P135 dipole located in the area around the secondary somatosensory cortex which has been shown to be associated with arousal and expectations. These findings corroborate the attentional model of pain catastrophizing by indicating that even non-painful stimuli are related to enhanced attention to and negative expectations of stimuli, and they suggest that memory processes may be central to understanding the link between catastrophizing and pain.

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Bromm B (2004) The involvement of the posterior cingulate gyrus in phasic pain processing of humans. Neurosci Lett 361:245–249. doi:10.1016/j.neulet.2004.01.018 PubMedCrossRef

Buchgreitz L, Egsgaard LL, Jensen R, Arendt-Nielsen L, Bendtsen L (2008) Abnormal pain processing in chronic tension-type headache: a high-density EEG brain mapping study. Brain 131:3232–3238. doi:10.1093/brain/awn199 PubMedCrossRef

Egsgaard LL, Buchgreitz L, Wang L, Bendtsen L, Jensen R, Arendt-Nielsen L (2012) Short term cortical plasticity induced by conditioning pain modulation. Exp Brain Res 216:91–101. doi:10.1007/s00221-011-2913-7 PubMedCrossRef

Flor H (2008) Maladaptive plasticity, memory for pain and phantom limb pain: review and suggestions for new therapies. Expert Rev Neuother 8:809–818CrossRef

Flor H, Birbaumer N (2000) Phantom limb pain: cortical plasticity and novel therapeutic approaches. Curr Opin Anaesthesiol 13:561–564PubMedCrossRef

Flor H, Elbert T, Knecht S, Wienbruch C, Pantev C, Birbaumer N, Larbig W, Taub E (1995) Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation. Nature 375:482–484. doi:10.1038/375482a0 PubMedCrossRef

Flor H, Elbert T, Muhlnickel W, Pantev C, Wienbruch C, Taub E (1998) Cortical reorganization and phantom phenomena in congenital and traumatic upper-extremity amputees. Exp Brain Res 119:205–212. doi:10.1586/14737175.8.5809 PubMedCrossRef

Flor H, Nikolajsen L, Staehelin Jensen T (2006) Phantom limb pain: a case of maladaptive CNS plasticity? Nat Rev Neurosci 7:873–881. doi:10.1038/nrn1991 PubMedCrossRef

Frot M, Rambaud L, Guenot M, Mauguiere F (1999) Intracortical recordings of early pain-related CO2-laser evoked potentials in the human second somatosensory (SII) area. Clin Neurophysiol 110:133–145PubMedCrossRef

Frot M, Garcia-Larrea L, Guenot M, Mauguiere F (2001) Responses of the supra-sylvian (SII) cortex in humans to painful and innocuous stimuli. A study using intra-cerebral recordings. Pain 94:65–73PubMedCrossRef

Gracely RH, Geisser ME, Giesecke T, Grant MA, Petzke F, Williams DA, Clauw DJ (2004) Pain catastrophizing and neural responses to pain among persons with fibromyalgia. Brain 127:835–843. doi:10.1093/brain/awh098 PubMedCrossRef

Gratkowski M, Haueisen J, Arendt-Nielsen L, Chen AC, Zanow F (2006) Time-frequency filtering of MEG signals with matching pursuit. J Physiol Paris 99:47–57. doi:10.1016/j.jphysparis.2005.06.009 PubMedCrossRef

Gratkowski M, Haueisen J, Arendt-Nielsen L, Chen AC, Zanow F (2008) Decomposition of biomedical signals in spatial and time-frequency modes. Methods Inf Med 47:26–37PubMed

Hanley MA, Jensen MP, Ehde DM, Hoffman AJ, Patterson DR, Robinson LR (2004) Psychosocial predictors of long-term adjustment to lower-limb amputation and phantom limb pain. Disabil Rehabil 26:882–893PubMedCrossRef

Hill A, Niven CA, Knussen C (1995) The role of coping in adjustment to phantom limb pain. Pain 62:79–86. http://www.brainvoyager.com/BrainTutor.html

Jensen MP, Ehde DM, Hoffman AJ, Patterson DR, Czerniecki JM, Robinson LR (2002) Cognitions, coping and social environment predict adjustment to phantom limb pain. Pain 95:133–142PubMedCrossRef

Lancaster JL, Woldorff MG, Parsons LM, Liotti M, Freitas CS, Rainey L, Kochunov PV, Nickerson D, Mikiten SA, Fox PT (2000) Automated Talairach atlas labels for functional brain mapping. Hum Brain Mapp 10:120–131PubMedCrossRef

Lefebvre JC, Keefe FJ (2002) Memory for pain: the relationship of pain catastrophizing to the recall of daily rheumatoid arthritis pain. Clin J Pain 18:56–63PubMedCrossRef

Linden DE (2005) The p300: where in the brain is it produced and what does it tell us? Neuroscientist 11:563–576. doi:10.1177/1073858405280524 PubMedCrossRef

Lopes da Silva FH, Wieringa HJ, Peters MJ (1991) Source localization of EEG versus MEG: empirical comparison using visually evoked responses and theoretical considerations. Brain Topogr 4:133–142PubMedCrossRef

Mallat SG, Zhang Z (1993) Matching pursuits with time-frequency dictionaries. IEEE Trans Signal Process 41:3397–3415CrossRef

Mersky H, Bogduk N (eds) (1994/2007) Classification on chronic pain, second ed. IASP task force on taxonomy. Part III: pain terms, a current list with definitions and notes on usage. IASP Press, Seattle

Michel CM, Murray MM, Lantz G, Gonzalez S, Spinelli L, Grave de Peralta R (2004) EEG source imaging. Clin Neurophysiol 115:2195–2222PubMedCrossRef

Niddam DM, Yeh TC, Wu YT, Lee PL, Ho LT, Arendt-Nielsen L, Chen AC, Hsieh JC (2002) Event-related functional MRI study on central representation of acute muscle pain induced by electrical stimulation. Neuroimage 17:1437–1450PubMedCrossRef

Nikolajsen L, Jensen TS (2001) Phantom limb pain. Br J Anaesth 87:107–116PubMedCrossRef

Oostenveld R, Praamstra P (2001) The five n electrode system for high-resolution EEG and ERP measurements. Clin Neurophysiol 112:713–719PubMedCrossRef

Price DD (1999) Psychological mechanisms of pain and analgesia. Progress in pain research and management. IAPS Press, Seattle

Price DD, Milling LS, Kirsch I, Duff A, Montgomery GH, Nicholls SS (1999) An analysis of factors that contribute to the magnitude of placebo analgesia in an experimental paradigm. Pain 83:147–156. doi:10.1016/s0304-3959(99)00081-0 PubMedCrossRef

Pritchard WS (1981) Psychophysiology of P300. Psychol Bull 89:506–540. doi:10.1037/0033-2909.89.3.506 PubMedCrossRef

Quartana PJ, Campbell CM, Edwards RR (2009) Pain catastrophizing: a critical review. Expert Rev Neurother 9:745–758PubMedCrossRef

Richardson C, Glenn S, Horgan M, Nurmikko T (2007) A prospective study of factors associated with the presence of phantom limb pain six months after major lower limb amputation in patients with peripheral vascular disease. J Pain 8:793–801. doi:10.1016/j.jpain.2007.05.007 PubMedCrossRef

Rosenstiel AK, Keefe FJ (1983) The use of coping strategies in chronic low back pain patients: relationship to patient characteristics and current adjustment. Pain 17:33–44PubMedCrossRef

Sawamoto N, Honda M, Okada T, Hanakawa T, Kanda M, Fukuyama H, Konishi J, Shibasaki H (2000) Expectation of pain enhances responses to nonpainful somatosensory stimulation in the anterior cingulate cortex and parietal operculum/posterior insula: an event-related functional magnetic resonance imaging study. J Neurosci 20:7438–7445PubMed

Seminowicz DA, Davis KD (2006) Cortical responses to pain in healthy individuals depends on pain catastrophizing. Pain 120:297–306. doi:10.1016/j.pain.2005.11.008 PubMedCrossRef

Sullivan MJL, Bishop SR, Pivik J (1995) The pain catastrophizing scale: development and validation. Psychol Assess 7:524–532. doi:10.1037/1040-3590.7.4.524 CrossRef

Sullivan MJ, Thorn B, Haythornthwaite JA, Keefe F, Martin M, Bradley LA, Lefebvre JC (2001) Theoretical perspectives on the relation between catastrophizing and pain. Clin J Pain 17:52–64PubMedCrossRef

Treede RD, Apkarian AV, Bromm B, Greenspan JD, Lenz FA (2000) Cortical representation of pain: functional characterization of nociceptive areas near the lateral sulcus. Pain 87:113–119PubMedCrossRef

Van Damme S, Crombez G, Eccleston C (2002) Retarded disengagement from pain: the role of catastrophic thinking about pain. Pain 100:11–18

Van Damme S, Crombez G, Eccleston C (2004) Disengagement from pain cues: the effects of pain catastrophizing and pain expectancy. Pain 107:70–76PubMedCrossRef

Vase L, Nikolajsen L, Christensen B, Egsgaard LL, Arendt-Nielsen L, Svensson P, Jensen TS (2011) Cognitive-emotional sensitization contributes to wind-up-like pain in phantom limb pain patients. Pain 152:157–162. doi:10.1016/j.pain.2010.10.013 PubMedCrossRef

Vecchiet L, Galletti R, Giamberardino MA, Dragani L, Marini F (1988) Modifications of cutaneous, subcutaneous, and muscular sensory and pain thresholds after the induction of an experimental algogenic focus in the skeletal muscle. Clin J Pain 4:55–60CrossRef

Whyte A, Carroll LJ (2004) The relationship between catastrophizing and disability in amputees experiencing phantom pain. Disabil Rehabil 26:649–654. doi:10.1080/09638280410001672508 PubMedCrossRef

Title: Pain catastrophizing and cortical responses in amputees with varying levels of phantom limb pain: a high-density EEG brain-mapping study
Authors: Lene Vase
Line Lindhardt Egsgaard
Lone Nikolajsen
Peter Svensson
Troels Staehelin Jensen
Lars Arendt-Nielsen
Publication date: 01-05-2012
Publisher: Springer-Verlag
Published in: Experimental Brain Research / Issue 3/2012
Print ISSN: 0014-4819
Electronic ISSN: 1432-1106
DOI: https://doi.org/10.1007/s00221-012-3027-6

At a glance: The STEP trials

Springer Medicine

Pain catastrophizing and cortical responses in amputees with varying levels of phantom limb pain: a high-density EEG brain-mapping study

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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