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01-11-2021 | Hyperparathyroidism | Short Communication

Higher serum levels of a cathepsin K–generated periostin fragment are associated with fractures in postmenopausal women with primary hyperparathyroidism: a pilot study

Authors: J. Pepe, N. Bonnet, C. Cipriani, C. Ferrara, M. Rossi, V. De Martino, L. Colangelo, C. Sonato, V. Cecchetti, S. Ferrari, S. Minisola

Published in: Osteoporosis International | Issue 11/2021

Abstract

Summary

The only difference between fractured and non-fractured postmenopausal women with PHPT of same sex, age, and BMI was a significantly mean higher serum k-periostin level. K-periostin value was associated with fracture at any site (odds ratio 1.044, 95% CI 1.005–1.091, p = 0.03).

Introduction

To assess serum k-periostin fragment levels in patients with primary hyperparathyroidism (PHPT), fractured and non-fractured matched for sex, age, and body mass index.

Methods

Twenty-five Caucasian fractured postmenopausal women with PHPT (group Fx) and 25 PHPT non-fractured (group NFx) were enrolled. Each patient underwent DXA scan at lumbar, hip, and forearm, spine X-ray, and biochemical evaluation of calcium metabolism. For k-periostin analyses, we utilized a specific ELISA test that detects CatK-generated fragment levels in the bloodstream.

Results

We found no difference in mean BMD and bone turnover marker values between Fx and NFx groups. Prevalence of osteoporosis was not significantly different in Fx vs NFx (72% vs 60%, p = 0.55). Among Fx, 16% reported multiple fractures, 28% morphometric vertebral fractures, 4% femoral fractures, 28% non-vertebral non-femoral fractures, and 8% wrist fractures. The only detectable difference between Fx and NFx group was a significantly mean higher k-periostin serum level (46.2 ± 21.4 vs 34.7 ± 13.5 ng/ml, p = 0.02). K-periostin was associated with fracture at any site (odds ratio 1.044, 95% CI 1.005–1.091, p = 0.03). No difference in mean k-periostin values was found between patients with vertebral fracture vs those with non-vertebral fracture, and between those with multiple fractures vs those with single fracture.

Conclusion

Serum k-periostin is significantly associated with fracture in PHPT. If confirmed by further studies, k-periostin could be considered a new marker of bone fragility in PHPT, independently of BMD.

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Title: Higher serum levels of a cathepsin K–generated periostin fragment are associated with fractures in postmenopausal women with primary hyperparathyroidism: a pilot study
Authors: J. Pepe
N. Bonnet
C. Cipriani
C. Ferrara
M. Rossi
V. De Martino
L. Colangelo
C. Sonato
V. Cecchetti
S. Ferrari
S. Minisola
Publication date: 01-11-2021
Publisher: Springer London
Keywords: Hyperparathyroidism
Osteoporosis
Osteoporosis
Published in: Osteoporosis International / Issue 11/2021
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-021-06018-x

Keynote webinar | Spotlight on medication adherence

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Higher serum levels of a cathepsin K–generated periostin fragment are associated with fractures in postmenopausal women with primary hyperparathyroidism: a pilot study

Abstract

Summary

Introduction

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusion

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