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01-04-2021 | Osteoporosis | Letter to the Editor

Using health-economic evidence to support policy-level decision-making in Singapore—sensitivity analysis that provides further confidence in fracture probability-based cost-effective intervention thresholds

Authors: M. Chandran, G. Ganesan, K. B. Tan, J.-Y. Reginster, M. Hiligsmann

Published in: Osteoporosis International | Issue 4/2021

Excerpt

FRAX®-based intervention thresholds (ITs) were identified in Singapore in 2018 [1]. Subsequently, in a separate study, the impact of age-dependent ITs was determined on a population-based sample [2]. The mean-weighted age-dependent thresholds identified in the two studies were mostly similar with a minor difference noted at older ages (e.g. at the age of 75 years, major osteoporotic fracture (MOF) IT being 24% for the former study vs 25.7% for the latter). The clinical impact of these minor differences noted at extremely old ages is unlikely to be significant and is presumed secondary to the small methodological differences between the two studies. …

Chandran M, McCloskey EV, Thu WPP, Logan S, Hao Y, Tay D, Ang WC, Aung TKK, Choo KS, Ali A, Yan SX, Huang XF, Liu XM, Yong EL, Lekamwasam S (2018) FRAX® based intervention thresholds for management of osteoporosis in Singaporean women. Arch Osteoporos 13(1):130CrossRef

Kanis JA, Chandran M, Chionh SB, Ganeson G, Harvey NC, Koh WP, Kwok T, Lau TC, Liu E, Lorentzon M, McCloskey EV, Tan KB, Vandenput L, Johansson H (2020) Use of age-dependent FRAX-based intervention thresholds for Singapore. Arch Osteoporos 15(1):104CrossRef

Chandran M, Ganesan G, Tan KB, Reginster JY, Hiligsmann M (2020) Cost-effectiveness of FRAX-based intervention thresholds for management of osteoporosis in Singaporean women. Osteoporos Int. https://doi.org/10.1007/s00198-020-05536-4

World Health Organization CHOosing Interventions that are Cost Effective (WHO-CHOICE): cost effectiveness thresholds. http://www.who.int/choice/costs/CER_thresholds/en/ Last accessed December 8 2020

Title: Using health-economic evidence to support policy-level decision-making in Singapore—sensitivity analysis that provides further confidence in fracture probability-based cost-effective intervention thresholds
Authors: M. Chandran
G. Ganesan
K. B. Tan
J.-Y. Reginster
M. Hiligsmann
Publication date: 01-04-2021
Publisher: Springer London
Keywords: Osteoporosis
Osteoporosis
Published in: Osteoporosis International / Issue 4/2021
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-021-05876-9

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Using health-economic evidence to support policy-level decision-making in Singapore—sensitivity analysis that provides further confidence in fracture probability-based cost-effective intervention thresholds

Excerpt

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