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Osteoporosis International

Published in:

01-03-2019 | Original Article

Long waiting time before tooth extraction may increase delayed wound healing in elderly Japanese

Authors: M. Kamimura, A. Taguchi, M. Komatsu, H. Koiwai, R. Ashizawa, A. Ichinose, K. Takahara, S. Uchiyama, H. Kato

Published in: Osteoporosis International | Issue 3/2019

Abstract

Summary

In osteoporosis patients receiving antiresorptive medications, stopping the drug and delaying tooth extraction has been suggested to reduce the risk of osteonecrosis of the jaw (ONJ). However, postponing tooth extraction for ≥ 2 months was associated with an increased risk of delayed wound healing beyond 8 weeks after extraction, a risk factor for developing ONJ.

Introduction

A long waiting time before tooth extraction could result from concern about a potential increased risk of osteonecrosis of the jaw (ONJ) in osteoporosis patients. We clarified whether a long waiting time before tooth extraction during the past year may be associated with an increased risk of delayed wound healing beyond 8 weeks after tooth extraction, which may be a risk factor of ONJ.

Methods

Of 5639 patients aged ≥ 60 years who visited our 20 clinics or hospitals and answered a structured questionnaire, 426 patients (151 men, 275 women) aged 60–96 years comprised the final participants in this study. Self-reported kyphosis was used as a surrogate marker of vertebral fractures. Stepwise logistic regression analysis, adjusted for covariates, was used to calculate the odds ratio (OR) and the 95% confidence interval (CI) for the presence of delayed wound healing longer than 8 weeks after tooth extraction during the past year based on the duration before extraction.

Results

Subjects who had waited > 2 months for tooth extraction had a significantly higher risk of delayed wound healing compared with those whose tooth was extracted within 1 month (OR = 7.23; 95% CI = 2.19–23.85, p = 0.001) regardless if antiresorptive medications for osteoporosis were used. The presence of self-reported kyphosis was significantly associated with an increased risk of delayed wound healing (OR = 5.08; 95% CI = 1.11–23.32, p = 0.036).

Conclusions

A long waiting time before tooth extraction may be a risk factor for delayed wound healing beyond 8 weeks after extraction in patients aged ≥ 60 years.

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Title: Long waiting time before tooth extraction may increase delayed wound healing in elderly Japanese
Authors: M. Kamimura
A. Taguchi
M. Komatsu
H. Koiwai
R. Ashizawa
A. Ichinose
K. Takahara
S. Uchiyama
H. Kato
Publication date: 01-03-2019
Publisher: Springer London
Published in: Osteoporosis International / Issue 3/2019
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-018-4775-3

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Long waiting time before tooth extraction may increase delayed wound healing in elderly Japanese

Abstract

Summary

Introduction

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusions

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