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01-11-2018 | Original Article

Incidence of subsequent fractures in the UK between 1990 and 2012 among individuals 50 years or older

Authors: R. Y. van der Velde, C. E. Wyers, P. P. M. M. Geusens, J. P. W. van den Bergh, F. de Vries, C. Cooper, T. P. van de Staa, N. C. Harvey

Published in: Osteoporosis International | Issue 11/2018

Abstract

Summary

We studied the incidence of subsequent fractures in persons of 50+ years from 1990 to 2012 and the relative risk (RR) of subsequent fractures after an index femur/hip fracture, stratified per 5-year age band. Patients suffering a fracture have a high incidence of a subsequent fracture; the RR of subsequent fracture after a femur/hip fracture ranged from 2 to 7.

Introduction

Recent information on the risk of subsequent fractures after a broad range of index fractures in the UK population is scarce. We therefore studied the rates of subsequent fractures of the femur/hip, humerus, radius/ulna, vertebrae, rib, or pelvis after fractures at one of these sites from 1990 to 2012 in 3,156,347 UK men and women aged 50 years or over.

Methods

We undertook a retrospective observational study using the UK Clinical Practice Research Datalink (CPRD). The incidence of subsequent fractures at a specific site was calculated by dividing the observed number of fractures by the number of person-years (py) at risk. The relative risk (RR) of subsequent fractures after a femur/hip fracture, by 5-year age band, was calculated by dividing the incidence of a specific subsequent fracture type by the incidence of first fractures at the same site in the same age group.

Results

The highest subsequent fracture incidence after a femur/hip fracture was for humerus fracture in men (59.5/10.000 py) and radius/ulna fracture in women (117.2/10.000 py). After an index fracture of the radius/ulna, humerus fracture in men (59.3/10.000 py) and femur/hip fracture in women (82.4 per 10.000 py) were most frequent. The RR of fractures after a femur/hip fracture ranged from 2 to 7 and were highest in men and younger age groups.

Conclusion

Patients suffering a fracture have a high incidence of a subsequent fracture. Our findings demonstrate the importance of fracture prevention in patients with a history of a fracture by adequate medical diagnosis and treatment.

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Title: Incidence of subsequent fractures in the UK between 1990 and 2012 among individuals 50 years or older
Authors: R. Y. van der Velde
C. E. Wyers
P. P. M. M. Geusens
J. P. W. van den Bergh
F. de Vries
C. Cooper
T. P. van de Staa
N. C. Harvey
Publication date: 01-11-2018
Publisher: Springer London
Published in: Osteoporosis International / Issue 11/2018
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-018-4636-0

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Incidence of subsequent fractures in the UK between 1990 and 2012 among individuals 50 years or older

Abstract

Summary

Introduction

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusion

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