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Osteoporosis International

Published in:

01-03-2016 | Original Article

Polymorphisms of the WNT16 gene are associated with the heel ultrasound parameter in young adults

Authors: M. Correa-Rodríguez, J. Schmidt Rio-Valle, B. Rueda-Medina

Published in: Osteoporosis International | Issue 3/2016

Abstract

Summary

Bone mineral content is influenced by genetic factors. We investigated the role of WNT16 in bone properties determined using quantitative ultrasound (QUS) on young adults. Three WNT16 genetic markers (rs2908007, rs2908004, and rs2707466) were found to have a significant association with the broadband ultrasound attenuation (BUA) measurement, suggesting that WNT16 influences bone mass in young adults.

Introduction

The aim of this study was to investigate whether genetic markers on the WNT16 gene are associated with bone mass, as assessed using QUS in a population of healthy young Spanish adults.

Methods

A cross-sectional study was conducted on 575 individuals (mean age 20.41 ± 2.69). Bone quality was assessed using BUA measurements (dB/MHz) on the right calcaneus. Six single nucleotide polymorphisms (SNPs) (rs2908007, rs2908004, rs3801387, rs3801385, rs2707466, and rs2536184) covering the WNT16 gene were selected as genetic markers and genotyped to test their association with BUA variations.

Results

The rs2908007, rs2908004, and rs2707466 SNPs were found to have a significant association with BUA (p = 0.004, p = 0.001, and p = 0.004, respectively).

Conclusion

We demonstrate for the first time that WNT16 genetic polymorphisms influence QUS traits in a population of young adults. This finding suggests that WNT16 might be an important genetic factor in determining peak bone mass acquisition.

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Title: Polymorphisms of the WNT16 gene are associated with the heel ultrasound parameter in young adults
Authors: M. Correa-Rodríguez
J. Schmidt Rio-Valle
B. Rueda-Medina
Publication date: 01-03-2016
Publisher: Springer London
Published in: Osteoporosis International / Issue 3/2016
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-015-3379-4

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Polymorphisms of the WNT16 gene are associated with the heel ultrasound parameter in young adults

Abstract

Summary

Introduction

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusion

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