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Osteoporosis International

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01-09-2015 | Original Article

Serum C3 epimer of 25-hydroxyvitamin D and its determinants in adults: a national health examination survey in Thais

Authors: L. Chailurkit, W. Aekplakorn, B. Ongphiphadhanakul

Published in: Osteoporosis International | Issue 9/2015

Abstract

Summary

A high percentage have detectable C3 epimer of 25-hydroxyvitamin D3 (3-epi-25(OH)D3) in the population of Thai National Health Examination Survey IV.

Introduction

C3 epimers of vitamin D have recently been shown to contribute significantly to 25-hydroxyvitamin D (25(OH)D) levels in an infant population. However, the findings in the general adult population are unclear. Therefore, the purpose of the present study is to determine the percentage of the C3 epimer of 25(OH)D (3-epi-25(OH)D) and its determinants in an adult population.

Methods

A subsample of 1148 sera randomly selected from the Thai National Health Examination Survey IV (2009) samples were measured for serum 25(OH)D2, 25(OH)D3, 3-epi-25(OH)D2, and 3-epi-25(OH)D3 by LC-MS/MS method. The relative 3-epimer contribution (%) was used to express the amount of 3-epimer-25(OH)D3 as a percentage of total 25(OH)D3 (the sum of 25(OH)D3, and 3-epi-25(OH)D3).

Results

A high proportion of subjects had detectable 3-epi-25(OH)D3 that was <10 % of the total 25(OH)D levels. Since the level of total 25(OH)D2 is low, only a minority of subjects had detectable 3-epi-25(OH)D2. Multivariate analysis suggested that age, male gender, and rural residence were independently related to the 3-epi-25(OH)D3/total 25(OH)D3 ratio.

Conclusions

A high percentage of Thai adults had detectable 3-epi-25(OH)D3 that was <10 % of the total 25(OH)D levels. Age, gender, and living in a rural area were associated with the relative amount of 3-epi-25(OH)D3 to total 25(OH)D3.

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Title: Serum C3 epimer of 25-hydroxyvitamin D and its determinants in adults: a national health examination survey in Thais
Authors: L. Chailurkit
W. Aekplakorn
B. Ongphiphadhanakul
Publication date: 01-09-2015
Publisher: Springer London
Published in: Osteoporosis International / Issue 9/2015
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-015-3125-y

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Serum C3 epimer of 25-hydroxyvitamin D and its determinants in adults: a national health examination survey in Thais

Abstract

Summary

Introduction

Methods

Results

Conclusions

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