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Osteoporosis International

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01-02-2013 | Original Article

Bisphosphonate use and increased incidence of subtrochanteric fracture in South Korea: results from the National Claim Registry

Authors: Y.-K. Lee, Y.-C. Ha, C. Park, J. J. Yoo, C. S. Shin, K.-H. Koo

Published in: Osteoporosis International | Issue 2/2013

Abstract

Summary

We evaluated trends in the incidences of typical and atypical hip fracture in relation to bisphosphonate use in Korea from 2006 to 2010, using nationwide data obtained from the Health Insurance Review and Assessment Service (HIRA).

Introduction

Recently, atypical hip fractures in the subtrochanteric region have been reported among patients on bisphosphonate. However, the association between atypical hip fracture and bisphosphonate is controversial. We evaluated trends in the incidences of typical and atypical hip fracture in relation to bisphosphonate use in Korea from 2006 to 2010, using nationwide data obtained from the HIRA.

Methods

All new visits or admissions to clinics or hospitals for a typical and atypical hip fractures were recorded nationwide by HIRA using the ICD-10 code classification. Typical and atypical hip fractures were defined as femoral neck/intertrochanteric and subtrochanteric fracture, respectively. Bisphosphonate prescription data were also abstracted from the HIRA database.

Results

The absolute number of typical and atypical hip fracture increased during the study period. Although age-adjusted incidence rates of typical hip fractures were stable in men and women, those of atypical hip fractures increased in women. Nationally, the annual numbers of prescriptions of bisphosphonate also increased during the study period.

Conclusions

The results of this study suggest a possible causal relationship between bisphosphonate use and the increased incidence of atypical hip fracture in Korea.

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Title: Bisphosphonate use and increased incidence of subtrochanteric fracture in South Korea: results from the National Claim Registry
Authors: Y.-K. Lee
Y.-C. Ha
C. Park
J. J. Yoo
C. S. Shin
K.-H. Koo
Publication date: 01-02-2013
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 2/2013
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-012-2016-8

At a glance: The STEP trials

Springer Medicine

Bisphosphonate use and increased incidence of subtrochanteric fracture in South Korea: results from the National Claim Registry

Abstract

Summary

Introduction

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusions

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