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Osteoporosis International
Published in: Osteoporosis International 9/2012

01-09-2012 | Original Article

Normalization of cortical bone density in children and adolescents with hyperthyroidism treated with antithyroid medication

Authors: N. Numbenjapon, G. Costin, P. Pitukcheewanont

Published in: Osteoporosis International | Issue 9/2012

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Abstract

Summary

We assessed bone size and bone density (BD) measurements using computed tomography (CT) in children and adolescents with hyperthyroidism treated with antithyroid medication. We found that cortical BD appeared to improve at 1 year and normalize at 2 years in all tested patients.

Introduction

Our previous study demonstrated that cortical BD in children and adolescents with untreated hyperthyroidism was significantly decreased as compared to age-, sex- and ethnicity-matched healthy controls. The present report evaluated whether attainment of euthyroidism by medical antithyroid treatment was able to improve or normalize cortical BD in these patients.

Methods

Anthropometrics and three-dimensional CT bone measurements including cross-sectional area (CSA), cortical bone area (CBA) and cortical BD at midshaft of the femur (cortical bone), and CSA and BD of L1 to L3 vertebrae (cancellous bone) in 15 children and adolescents after 1- and 2-year treatments with antithyroid medication were reviewed and compared to their pretreatment results.

Results

All patients were euthyroid at 1 and 2 years after medical antithyroid treatment. After adjusting for age, height, weight and Tanner stage, a significant increase in cortical BD in all patients (15/15) was found after 1 year of treatment (P < 0.001). Normalization of cortical BD was demonstrated in all tested patients (10/15) after 2 years. There were no significant changes in the other cancellous or cortical bone parameters.

Conclusion

Cortical BD was improved at 1 year and normalized at 2 years in hyperthyroid patients rendered euthyroid with antithyroid medication.
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Metadata
Title
Normalization of cortical bone density in children and adolescents with hyperthyroidism treated with antithyroid medication
Authors
N. Numbenjapon
G. Costin
P. Pitukcheewanont
Publication date
01-09-2012
Publisher
Springer-Verlag
Published in
Osteoporosis International / Issue 9/2012
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-011-1867-8

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