Skip to main content
Top
Published in: Osteoporosis International 4/2011

01-04-2011 | Original Article

Clinical and demographic factors associated with fractures among older Americans

Authors: A. J. Taylor, L. C. Gary, T. Arora, D. J. Becker, J. R. Curtis, M. L. Kilgore, M. A. Morrisey, K. G. Saag, R. Matthews, H. Yun, W. Smith, E. Delzell

Published in: Osteoporosis International | Issue 4/2011

Login to get access

Abstract

Summary

Medicare claims data were used to investigate associations between history of previous fractures, chronic conditions, and demographic characteristics and occurrence of fractures at six anatomic sites. The study confirmed previously established associations for hip and spine fractures and identified several new associations of interest for nonhip, nonspine fractures.

Introduction

This study investigates the associations of a history of fracture, comorbid chronic conditions, and demographic characteristics with incident fractures among Medicare beneficiaries. The majority of fracture incidence studies have focused on the hip and on white females. This study examines a greater variety of fracture sites and more population subgroups than prior studies.

Methods

We used Medicare claims data to examine the incidence of fracture at six anatomic sites in a random 5% sample of Medicare beneficiaries during the time period 2000 through 2005.

Results

For each type of incident fracture, women had a higher rate than men, and there was a positive association with age and an inverse association with income. Whites had a higher rate than nonwhites. Rates were lowest among African-Americans for all sites except ankle and tibia/fibula, which were lowest among Asian-Americans. Rates of hip and spine fracture were highest in the South, and fractures of other sites were highest in the Northeast. Fall-related conditions and depressive illnesses were associated with each type of incident fracture, conditions treated with glucocorticoids with hip and spine fractures and diabetes with ankle and humerus fractures. Histories of hip and spine fractures were associated positively with each site of incident fracture except ankle; histories of nonhip, nonspine fractures were associated with most types of incident fracture.

Conclusions

This study confirmed previously established associations for hip and spine fractures and identified several new associations of interest for nonhip, nonspine fractures.
Appendix
Available only for authorised users
Literature
1.
go back to reference Melton LJ (1996) Epidemiology of hip fractures: implications of the exponential increase with age. Bone 18:121S–125SPubMedCrossRef Melton LJ (1996) Epidemiology of hip fractures: implications of the exponential increase with age. Bone 18:121S–125SPubMedCrossRef
2.
go back to reference Felsenberg D, Silman AJ, Lunt M, Armbrecht G, Ismail AA (2002) Incidence of vertebral fracture in Europe: results from the European Prospective Osteoporosis Study (EPOS). J Bone Miner Res 17:716–724CrossRef Felsenberg D, Silman AJ, Lunt M, Armbrecht G, Ismail AA (2002) Incidence of vertebral fracture in Europe: results from the European Prospective Osteoporosis Study (EPOS). J Bone Miner Res 17:716–724CrossRef
3.
go back to reference Chang KPCJ, Nguyen TV (2004) Incidence of hip and other osteoporotic fractures in elderly men and women: Dubbo Osteoporosis Epidemiology Study. J Bone Miner Res 19:532–536PubMedCrossRef Chang KPCJ, Nguyen TV (2004) Incidence of hip and other osteoporotic fractures in elderly men and women: Dubbo Osteoporosis Epidemiology Study. J Bone Miner Res 19:532–536PubMedCrossRef
4.
go back to reference Baron JA, Karagas M, Barrett J, Kniffin W, Malenda D, Mayor M, Keller RB (1996) Basic epidemiology of fractures of the upper and lower limb among Americans over 65 years of age. Epidemiology 7:612–618PubMedCrossRef Baron JA, Karagas M, Barrett J, Kniffin W, Malenda D, Mayor M, Keller RB (1996) Basic epidemiology of fractures of the upper and lower limb among Americans over 65 years of age. Epidemiology 7:612–618PubMedCrossRef
5.
go back to reference van Staa TP, Dennison EM, Leufkens HG, Cooper C (2001) Epidemiology of fractures in England and Wales. Bone 29:517–522PubMedCrossRef van Staa TP, Dennison EM, Leufkens HG, Cooper C (2001) Epidemiology of fractures in England and Wales. Bone 29:517–522PubMedCrossRef
6.
go back to reference Jones G, Nguyen T, Sambrook PN, Kelly PJ, Gilbert C, Eisman JA (1994) Symptomatic fracture incidence in elderly men and women: the Dubbo Osteoporosis Epidemiology Study (DOES). Osteoporos Int 4:277–282PubMedCrossRef Jones G, Nguyen T, Sambrook PN, Kelly PJ, Gilbert C, Eisman JA (1994) Symptomatic fracture incidence in elderly men and women: the Dubbo Osteoporosis Epidemiology Study (DOES). Osteoporos Int 4:277–282PubMedCrossRef
7.
go back to reference Sanders KM, Seeman E, Ugoni AM, Pasco JA, Martin TJ, Skoric B, Nicholson GC, Kotowicz MA (1999) Age- and gender-specific rate of fractures in Australia: a population-based study. Osteoporos Int 10:240–247PubMedCrossRef Sanders KM, Seeman E, Ugoni AM, Pasco JA, Martin TJ, Skoric B, Nicholson GC, Kotowicz MA (1999) Age- and gender-specific rate of fractures in Australia: a population-based study. Osteoporos Int 10:240–247PubMedCrossRef
8.
go back to reference Baron JA, Barrett J, Malenka D, Fisher E, Kniffin W, Bubolz T, Tosteson T (1994) Racial differences in fracture risk. Epidemiology 5:42–47PubMedCrossRef Baron JA, Barrett J, Malenka D, Fisher E, Kniffin W, Bubolz T, Tosteson T (1994) Racial differences in fracture risk. Epidemiology 5:42–47PubMedCrossRef
9.
go back to reference Barrett-Connor E, Siris ES, Wehren LE, Miller PD, Abbott TA, Berger ML, Santora AC, Sherwood LM (2005) Osteoporosis and fracture risk in women of different ethnic groups. J Bone Miner Res 20:185–194PubMedCrossRef Barrett-Connor E, Siris ES, Wehren LE, Miller PD, Abbott TA, Berger ML, Santora AC, Sherwood LM (2005) Osteoporosis and fracture risk in women of different ethnic groups. J Bone Miner Res 20:185–194PubMedCrossRef
10.
go back to reference Cauley JA, Wampler NS, Barnhart JM, Wu L, Allison M, Chen Z, Hendrix S, Robbins J, Jackson RD (2008) Incidence of fractures compared to cardiovascular disease and breast cancer: The Women's Health Initiative Observational Study. Osteoporos Int 19:1717–1723PubMedCrossRef Cauley JA, Wampler NS, Barnhart JM, Wu L, Allison M, Chen Z, Hendrix S, Robbins J, Jackson RD (2008) Incidence of fractures compared to cardiovascular disease and breast cancer: The Women's Health Initiative Observational Study. Osteoporos Int 19:1717–1723PubMedCrossRef
11.
go back to reference Cauley JA, Lui LY, Ensrud KE, Zmuda JM (2005) Bone mineral density and the risk of incident nonspinal fractures in black and white women. JAMA 293:2102–2108PubMedCrossRef Cauley JA, Lui LY, Ensrud KE, Zmuda JM (2005) Bone mineral density and the risk of incident nonspinal fractures in black and white women. JAMA 293:2102–2108PubMedCrossRef
12.
go back to reference Stone KL, Seeley DG, Lui LY, Cauley JA, Ensrud K, Browner WS, Nevitt MC, Cummings SR (2003) BMD at multiple sites and risk of fracture of multiple types: long-term results from the study of osteoporotic fractures. J Bone Miner Res 18:1947–1954PubMedCrossRef Stone KL, Seeley DG, Lui LY, Cauley JA, Ensrud K, Browner WS, Nevitt MC, Cummings SR (2003) BMD at multiple sites and risk of fracture of multiple types: long-term results from the study of osteoporotic fractures. J Bone Miner Res 18:1947–1954PubMedCrossRef
13.
go back to reference Klotzbuecher CM, Ross PD, Landsman PB, Abbott TA, Berger M (2000) Patients with prior fractures have an increased risk of future fractures: a summary of the literature and statistical synthesis. J Bone Miner Res 15:721–739PubMedCrossRef Klotzbuecher CM, Ross PD, Landsman PB, Abbott TA, Berger M (2000) Patients with prior fractures have an increased risk of future fractures: a summary of the literature and statistical synthesis. J Bone Miner Res 15:721–739PubMedCrossRef
14.
go back to reference Kanis JA, Johnell O, De Laet C, Johansson H, Oden A, Delmas P, Eisman J (2004) A meta-analysis of previous fracture and subsequent fracture risk. Bone 35:375–382PubMedCrossRef Kanis JA, Johnell O, De Laet C, Johansson H, Oden A, Delmas P, Eisman J (2004) A meta-analysis of previous fracture and subsequent fracture risk. Bone 35:375–382PubMedCrossRef
15.
go back to reference Nguyen ND, Pongchaiyakul C, Center JR, Eisman JA, Nguyen TV (2005) Identification of high-risk individuals for hip fracture: a 14-year prospective study. J Bone Miner Res 20:1921–1928PubMedCrossRef Nguyen ND, Pongchaiyakul C, Center JR, Eisman JA, Nguyen TV (2005) Identification of high-risk individuals for hip fracture: a 14-year prospective study. J Bone Miner Res 20:1921–1928PubMedCrossRef
16.
go back to reference LaFleur J, McAdam-Marx C, Kirkness C, Brixner DI (2008) Clinical risk factors for fracture in postmenopausal osteoporotic women: a review of the recent literature. Ann Pharmacother 42:375–386PubMedCrossRef LaFleur J, McAdam-Marx C, Kirkness C, Brixner DI (2008) Clinical risk factors for fracture in postmenopausal osteoporotic women: a review of the recent literature. Ann Pharmacother 42:375–386PubMedCrossRef
17.
go back to reference Cummings SR, Melton LJ (2002) Epidemiology and outcomes of osteoporotic fractures. Lancet 359:1761–1767PubMedCrossRef Cummings SR, Melton LJ (2002) Epidemiology and outcomes of osteoporotic fractures. Lancet 359:1761–1767PubMedCrossRef
18.
go back to reference Cauley JA, Wu L, Wampler NS, Barnhart JM, Allison M, Chen Z, Jackson R, Robbins J (2007) Clinical risk factors for fractures in multi-ethnic women: The Women's Health Initiative. J Bone Miner Res 22:1816–1826PubMedCrossRef Cauley JA, Wu L, Wampler NS, Barnhart JM, Allison M, Chen Z, Jackson R, Robbins J (2007) Clinical risk factors for fractures in multi-ethnic women: The Women's Health Initiative. J Bone Miner Res 22:1816–1826PubMedCrossRef
19.
go back to reference Nickolas TL, Leonard MB, Shane E (2008) Chronic kidney disease and bone fracture: a growing concern. Kidney Int 74:721–731PubMedCrossRef Nickolas TL, Leonard MB, Shane E (2008) Chronic kidney disease and bone fracture: a growing concern. Kidney Int 74:721–731PubMedCrossRef
20.
go back to reference Whooley MA, Kip KE, Cauley JA, Ensrud KE, Nevitt MC, Browner WS, Study of Osteoporotic Fractures Research Group (1999) Depression, falls, and risk of fracture in older women. Arch Intern Med 159:484–490PubMedCrossRef Whooley MA, Kip KE, Cauley JA, Ensrud KE, Nevitt MC, Browner WS, Study of Osteoporotic Fractures Research Group (1999) Depression, falls, and risk of fracture in older women. Arch Intern Med 159:484–490PubMedCrossRef
21.
go back to reference De Laet C, Kanis JA, Oden A, Johanson H, Johnell O (2005) Body mass index as a predictor of fracture risk: a meta-analysis. Osteoporos Int 16:1330–1338PubMedCrossRef De Laet C, Kanis JA, Oden A, Johanson H, Johnell O (2005) Body mass index as a predictor of fracture risk: a meta-analysis. Osteoporos Int 16:1330–1338PubMedCrossRef
22.
go back to reference Kanis JA, Johansson H, Oden AJO, de Laet C, Melton LJ III, Tenenhouse A, Reeve J, Silman AJ, Pols HA, Eisman JA, McCloskey EV, Mellstrom D (2004) A meta-analysis of prior corticosteroid use and fracture risk. J Bone Miner Res 19:893–899PubMedCrossRef Kanis JA, Johansson H, Oden AJO, de Laet C, Melton LJ III, Tenenhouse A, Reeve J, Silman AJ, Pols HA, Eisman JA, McCloskey EV, Mellstrom D (2004) A meta-analysis of prior corticosteroid use and fracture risk. J Bone Miner Res 19:893–899PubMedCrossRef
23.
go back to reference Delmas PD, Marin F, Marcus R, Misurski DA, Mitlak BH (2007) Beyond hip: importance of other nonspinal fractures. Am J Med 120:381–387PubMedCrossRef Delmas PD, Marin F, Marcus R, Misurski DA, Mitlak BH (2007) Beyond hip: importance of other nonspinal fractures. Am J Med 120:381–387PubMedCrossRef
24.
go back to reference Griffin MR, Ray W, Fought RL, Melton JL (1992) Black-white differences in fracture rates. Am J Epidemiol 136:1378–1385PubMed Griffin MR, Ray W, Fought RL, Melton JL (1992) Black-white differences in fracture rates. Am J Epidemiol 136:1378–1385PubMed
25.
go back to reference CDC (1996) Incidence and costs to Medicare of fractures among Medicare beneficiaries aged > or =65 years—United States, July 1991-June 1992. MMWR 45:877–883 CDC (1996) Incidence and costs to Medicare of fractures among Medicare beneficiaries aged > or =65 years—United States, July 1991-June 1992. MMWR 45:877–883
26.
go back to reference Brauer CA, Coca-Perraillon M, Cutler DM, Rosen AB (2009) Incidence and mortality of hip fractures in the United States. JAMA 302:1573–1579PubMedCrossRef Brauer CA, Coca-Perraillon M, Cutler DM, Rosen AB (2009) Incidence and mortality of hip fractures in the United States. JAMA 302:1573–1579PubMedCrossRef
27.
go back to reference Stroup NE, Freni-Titulaer LWJ, Schwartz JJ (1990) Unexpected geographic variation in rates of hospitalization for patients who have fracture of the hip. J Bone Joint Surg Am 72:1294–1298PubMed Stroup NE, Freni-Titulaer LWJ, Schwartz JJ (1990) Unexpected geographic variation in rates of hospitalization for patients who have fracture of the hip. J Bone Joint Surg Am 72:1294–1298PubMed
28.
go back to reference Karagas MR, Baron JA, Barrett JA, Jacobsen SJ (1996) Patterns of fracture among the United States elderly: geographic and fluoride effects. Ann Epidemiol 6:209–216PubMedCrossRef Karagas MR, Baron JA, Barrett JA, Jacobsen SJ (1996) Patterns of fracture among the United States elderly: geographic and fluoride effects. Ann Epidemiol 6:209–216PubMedCrossRef
29.
go back to reference Lauderdale DS, Thisted RA, Goldberg J (1998) Is geographic variation in hip fracture rates related to current or former region of residence? Epidemiology 9:574–577PubMedCrossRef Lauderdale DS, Thisted RA, Goldberg J (1998) Is geographic variation in hip fracture rates related to current or former region of residence? Epidemiology 9:574–577PubMedCrossRef
30.
go back to reference Sporer SM, Weinstein JN, Koval KJ (2006) The geographic incidence and treatment variation of common fractures of elderly patients. J Am Acad Orthop Surg 14:246–255PubMed Sporer SM, Weinstein JN, Koval KJ (2006) The geographic incidence and treatment variation of common fractures of elderly patients. J Am Acad Orthop Surg 14:246–255PubMed
31.
go back to reference Jacobsen SJ, Goldberg J, Miles TP, Brody JA, Stiers W, Rimm AA (1990) Regional variation in the incidence of hip fracture. US white women aged 65 years and older. JAMA 264:500–502PubMedCrossRef Jacobsen SJ, Goldberg J, Miles TP, Brody JA, Stiers W, Rimm AA (1990) Regional variation in the incidence of hip fracture. US white women aged 65 years and older. JAMA 264:500–502PubMedCrossRef
32.
go back to reference Jacobsen SJ, Cooper C, Gottlieb MS, Goldberg J, Yahnke DP, Melton LJ 3rd (1992) Hospitalization with vertebral fracture among the aged: a national population-based study, 1986–1989. Epidemiology 3:515–518PubMedCrossRef Jacobsen SJ, Cooper C, Gottlieb MS, Goldberg J, Yahnke DP, Melton LJ 3rd (1992) Hospitalization with vertebral fracture among the aged: a national population-based study, 1986–1989. Epidemiology 3:515–518PubMedCrossRef
33.
go back to reference Hinton RY, Lennox DW, Ebert FR, Jacobsen SJ, Smith GS (1995) Relative rates of fracture of the hip in the United States. Geographic, sex, and age variations. Bone Joint Surg Am 77:695–702 Hinton RY, Lennox DW, Ebert FR, Jacobsen SJ, Smith GS (1995) Relative rates of fracture of the hip in the United States. Geographic, sex, and age variations. Bone Joint Surg Am 77:695–702
34.
go back to reference Koval KJ, Lurie J, Zhou W, Sparks MB, Cantu RV, Sporer SM, Weinstein J (2005) Ankle fractures in the elderly: what you get depends on where you live and who you see. J Orthop Trauma 19:635–639PubMedCrossRef Koval KJ, Lurie J, Zhou W, Sparks MB, Cantu RV, Sporer SM, Weinstein J (2005) Ankle fractures in the elderly: what you get depends on where you live and who you see. J Orthop Trauma 19:635–639PubMedCrossRef
35.
go back to reference Lauderdale DS, Jacobsen SJ, Furner SE, Levy PS, Brody JA, Goldberg J (1997) Hip fracture incidence among elderly Asian-American populations. Am J Epidemiol 146:502–509PubMed Lauderdale DS, Jacobsen SJ, Furner SE, Levy PS, Brody JA, Goldberg J (1997) Hip fracture incidence among elderly Asian-American populations. Am J Epidemiol 146:502–509PubMed
36.
go back to reference Lauderdale DS, Jacobsen SJ, Furner SE, Levy PS, Brody JA, Goldberg J (1998) Hip fracture incidence among elderly Hispanics. Am J Public Health 88:1245–1247PubMedCrossRef Lauderdale DS, Jacobsen SJ, Furner SE, Levy PS, Brody JA, Goldberg J (1998) Hip fracture incidence among elderly Hispanics. Am J Public Health 88:1245–1247PubMedCrossRef
37.
go back to reference Yuan Z, Dawson N, Cooper GS, Einstadter D, Cebul R, Rimm AA (2001) Effects of alcohol-related disease on hip fracture and mortality: a retrospective cohort study of hospitalized Medicare beneficiaries. Am J Public Health 91:1089–1093PubMedCrossRef Yuan Z, Dawson N, Cooper GS, Einstadter D, Cebul R, Rimm AA (2001) Effects of alcohol-related disease on hip fracture and mortality: a retrospective cohort study of hospitalized Medicare beneficiaries. Am J Public Health 91:1089–1093PubMedCrossRef
38.
go back to reference Sugarman JR, Connell FA, Hansen A, Helgerson SD, Jessup MC, Lee H (2002) Hip fracture incidence in nursing home residents and community-dwelling older people, Washington State, 1993–1995. J Am Geriatr Soc 50:1638–1643PubMedCrossRef Sugarman JR, Connell FA, Hansen A, Helgerson SD, Jessup MC, Lee H (2002) Hip fracture incidence in nursing home residents and community-dwelling older people, Washington State, 1993–1995. J Am Geriatr Soc 50:1638–1643PubMedCrossRef
39.
go back to reference Colón-Emeric CS, Biggs DP, Schenck AP, Lyles KW (2003) Risk factors for hip fracture in skilled nursing facilities: who should be evaluated? Osteoporos Int 14:484–489PubMedCrossRef Colón-Emeric CS, Biggs DP, Schenck AP, Lyles KW (2003) Risk factors for hip fracture in skilled nursing facilities: who should be evaluated? Osteoporos Int 14:484–489PubMedCrossRef
40.
go back to reference Lamont EB, Lauderdale DS (2003) Low risk of hip fracture among elderly breast cancer survivors. Ann Epidemiol 13:698–703PubMedCrossRef Lamont EB, Lauderdale DS (2003) Low risk of hip fracture among elderly breast cancer survivors. Ann Epidemiol 13:698–703PubMedCrossRef
41.
go back to reference Baxter NN, Habermann EB, Tepper JE, Durham SB, Virnig BA (2005) Risk of pelvic fractures in older women following pelvic irradiation. JAMA 294:2587–2593PubMedCrossRef Baxter NN, Habermann EB, Tepper JE, Durham SB, Virnig BA (2005) Risk of pelvic fractures in older women following pelvic irradiation. JAMA 294:2587–2593PubMedCrossRef
42.
go back to reference Gage BF, Birman-Deych E, Radford MJ, Nilasena DS, Binder DF (2006) Risk of osteoporotic fracture in elderly patients taking warfarin. Arch Intern Med 166:241–246PubMedCrossRef Gage BF, Birman-Deych E, Radford MJ, Nilasena DS, Binder DF (2006) Risk of osteoporotic fracture in elderly patients taking warfarin. Arch Intern Med 166:241–246PubMedCrossRef
43.
go back to reference Liperoti R, Onder G, Lapane KL, Mor V, Friedman JH, Bernabei R, Gambassi G (2007) Conventional or atypical antipsychotics and the risk of femur fracture among elderly patients: results of a case-control study. J Clin Psychiatry 68:929–934PubMedCrossRef Liperoti R, Onder G, Lapane KL, Mor V, Friedman JH, Bernabei R, Gambassi G (2007) Conventional or atypical antipsychotics and the risk of femur fracture among elderly patients: results of a case-control study. J Clin Psychiatry 68:929–934PubMedCrossRef
44.
go back to reference Lyles KWSA, Colón-Emeric CS (2008) Hip and other osteoporotic fractures increase the risk of subsequent fractures in nursing home residents. Osteoporos Int 19:1225–1233PubMedCrossRef Lyles KWSA, Colón-Emeric CS (2008) Hip and other osteoporotic fractures increase the risk of subsequent fractures in nursing home residents. Osteoporos Int 19:1225–1233PubMedCrossRef
46.
go back to reference Ray WA, Griffin MR, Fought RL, Adams ML (1992) Identification of fractures from computerized Medicare files. J Clin Epidemiol 45:703–714PubMedCrossRef Ray WA, Griffin MR, Fought RL, Adams ML (1992) Identification of fractures from computerized Medicare files. J Clin Epidemiol 45:703–714PubMedCrossRef
47.
go back to reference Curtis JR, Mudano A, Solomon DH, Kim Y, Saag KG (2007) Identifying clinical vertebral fracture using administrative claims data: a validation study. J Bone Miner Res 22:Abstract M354:S199. Curtis JR, Mudano A, Solomon DH, Kim Y, Saag KG (2007) Identifying clinical vertebral fracture using administrative claims data: a validation study. J Bone Miner Res 22:Abstract M354:S199.
48.
go back to reference Morrill R, Cromartie J, Hart LG (1999) Metropolitan, urban, and rural commuting area: toward a better depiction of the U.S. settlement system. Urban Geogr 20:727–748CrossRef Morrill R, Cromartie J, Hart LG (1999) Metropolitan, urban, and rural commuting area: toward a better depiction of the U.S. settlement system. Urban Geogr 20:727–748CrossRef
51.
go back to reference Leslie WD, O’Donnell S, Jean S, Lagace C, Walsh P, Bancej C, Morin S, Hanley DA, Papaioannou A (2009) Trends in hip fracture rates in Canada. JAMA 302:883–889PubMedCrossRef Leslie WD, O’Donnell S, Jean S, Lagace C, Walsh P, Bancej C, Morin S, Hanley DA, Papaioannou A (2009) Trends in hip fracture rates in Canada. JAMA 302:883–889PubMedCrossRef
52.
go back to reference Zingmond DS, Soohoo NF, SL S (2006) The role of socioeconomic status on hip fracture. Osteoporos Int 17:1562–1568PubMedCrossRef Zingmond DS, Soohoo NF, SL S (2006) The role of socioeconomic status on hip fracture. Osteoporos Int 17:1562–1568PubMedCrossRef
53.
go back to reference Bacon WE, Hadden WC (2000) Occurrence of hip fractures and socioeconomic position. J Aging Health 12:193–203PubMedCrossRef Bacon WE, Hadden WC (2000) Occurrence of hip fractures and socioeconomic position. J Aging Health 12:193–203PubMedCrossRef
54.
go back to reference van Staa TP, Leufkens HGM, Cooper C (2002) The epidemiology of corticosteroid-induced osteoporosis: a metaanalysis. Osteoporos Int 10:777–787CrossRef van Staa TP, Leufkens HGM, Cooper C (2002) The epidemiology of corticosteroid-induced osteoporosis: a metaanalysis. Osteoporos Int 10:777–787CrossRef
55.
go back to reference Ismail AA, Cockerill W, Cooper C, Finn JD, Abendroth K, Parisi G, Banzer D, Benevolenskaya LI, Bhalla AK, Armas JB, Cannata JB, Delmas PD (2001) Prevalent vertebral deformity predicts incident hip though not distal forearm fracture: results from the European Prospective Osteoporosis Study. Osteoporos Int 12:85–90PubMedCrossRef Ismail AA, Cockerill W, Cooper C, Finn JD, Abendroth K, Parisi G, Banzer D, Benevolenskaya LI, Bhalla AK, Armas JB, Cannata JB, Delmas PD (2001) Prevalent vertebral deformity predicts incident hip though not distal forearm fracture: results from the European Prospective Osteoporosis Study. Osteoporos Int 12:85–90PubMedCrossRef
56.
go back to reference Cuddihy MT, Gabriel SE, Crowson CS, O’Fallon WM, Melton LJ 3rd (1999) Forearm fractures as predictors of subsequent osteoporotic fractures. Osteoporos Int 9:469–475PubMed Cuddihy MT, Gabriel SE, Crowson CS, O’Fallon WM, Melton LJ 3rd (1999) Forearm fractures as predictors of subsequent osteoporotic fractures. Osteoporos Int 9:469–475PubMed
57.
go back to reference AEJ MLJ, Cooper C, O’Fallon WM, Riggs BL (1999) Vertebral fractures predict subsequent fractures. Osteoporos Int 10:214–221CrossRef AEJ MLJ, Cooper C, O’Fallon WM, Riggs BL (1999) Vertebral fractures predict subsequent fractures. Osteoporos Int 10:214–221CrossRef
58.
go back to reference Black DM, Arden NK, Palermo L, Pearson J, Cummings SR (1999) Prevalent vertebral deformities predict hip fractures and new vertebral deformities but not wrist fractures. Study of Osteoporotic Fractures Research Group. J Bone Miner Res 14:821–828PubMedCrossRef Black DM, Arden NK, Palermo L, Pearson J, Cummings SR (1999) Prevalent vertebral deformities predict hip fractures and new vertebral deformities but not wrist fractures. Study of Osteoporotic Fractures Research Group. J Bone Miner Res 14:821–828PubMedCrossRef
59.
go back to reference Davis JW, Grove JS, Wasnich RD, Ross PD (1999) Spatial relationships between prevalent and incident spine fractures. Bone 24:261–264PubMedCrossRef Davis JW, Grove JS, Wasnich RD, Ross PD (1999) Spatial relationships between prevalent and incident spine fractures. Bone 24:261–264PubMedCrossRef
60.
go back to reference Ross PD, Genant HK, Davis JW, Miller PD, Wasnich RD (1993) Predicting vertebral fracture incidence from prevalent fractures and bone density among non-black, osteoporotic women. Osteoporos Int 3:120–126PubMedCrossRef Ross PD, Genant HK, Davis JW, Miller PD, Wasnich RD (1993) Predicting vertebral fracture incidence from prevalent fractures and bone density among non-black, osteoporotic women. Osteoporos Int 3:120–126PubMedCrossRef
61.
go back to reference Mezuk B, Eaton W, Golden SH (2008) Depression and osteoporosis: epidemiology and potential mediating pathways. Osteoporos Int 19:1–12PubMedCrossRef Mezuk B, Eaton W, Golden SH (2008) Depression and osteoporosis: epidemiology and potential mediating pathways. Osteoporos Int 19:1–12PubMedCrossRef
62.
go back to reference Rolland Y, Abellan van Kan G, Benetos A, Blain H, Bonnefoy M, Chassagne P, Jeandel C, Laroche M, Nourhashemi F, Orcel P, Piette F, Ribot C, Ritz P, Roux C, Taillandier J, Tremollieres F, Weryha G, Vellas B (2008) Frailty, osteoporosis and hip fracture: causes, consequences and therapeutic perspectives. J Nutr Health Aging 12:335–346PubMedCrossRef Rolland Y, Abellan van Kan G, Benetos A, Blain H, Bonnefoy M, Chassagne P, Jeandel C, Laroche M, Nourhashemi F, Orcel P, Piette F, Ribot C, Ritz P, Roux C, Taillandier J, Tremollieres F, Weryha G, Vellas B (2008) Frailty, osteoporosis and hip fracture: causes, consequences and therapeutic perspectives. J Nutr Health Aging 12:335–346PubMedCrossRef
63.
go back to reference Liu B, Anderson G, Mittmann N, To T, Axcell T, Shear N (1998) Use of selective serotonin-reuptake inhibitors of tricyclic antidepressants and risk of hip fractures in elderly people. Lancet 351:1303–1307PubMedCrossRef Liu B, Anderson G, Mittmann N, To T, Axcell T, Shear N (1998) Use of selective serotonin-reuptake inhibitors of tricyclic antidepressants and risk of hip fractures in elderly people. Lancet 351:1303–1307PubMedCrossRef
64.
go back to reference Robbins J, Hirsch C, Whitmer R, Cauley J, Harris T (2001) The association of bone mineral density and depression in an older population. J Am Geriatr Soc 49:732–736PubMedCrossRef Robbins J, Hirsch C, Whitmer R, Cauley J, Harris T (2001) The association of bone mineral density and depression in an older population. J Am Geriatr Soc 49:732–736PubMedCrossRef
65.
go back to reference Bonds DE, Larson JC, Schwartz AV, Strotmeyer ES, Robbins J, Rodriguez BL, Johnson KC, Margolis KL (2006) Risk of fracture in women with type 2 diabetes: the Women’s Health Initiative Observational Study. J Clin Endocrinol Metab 19:3404–3410CrossRef Bonds DE, Larson JC, Schwartz AV, Strotmeyer ES, Robbins J, Rodriguez BL, Johnson KC, Margolis KL (2006) Risk of fracture in women with type 2 diabetes: the Women’s Health Initiative Observational Study. J Clin Endocrinol Metab 19:3404–3410CrossRef
66.
go back to reference Holmberg AH, Johnell O, Nilsson PM (2006) Risk factors for fragility fracture in middle age. A prospective population-based study of 33, 000 men and women. Osteoporos Int 17:1065–1077PubMedCrossRef Holmberg AH, Johnell O, Nilsson PM (2006) Risk factors for fragility fracture in middle age. A prospective population-based study of 33, 000 men and women. Osteoporos Int 17:1065–1077PubMedCrossRef
67.
go back to reference Schwartz A, Sellmeyer D, Ensrud K (2001) Older women with diabetes have an increased risk of fracture: a prospective study. J Clin Endocrinol Metab 86:32–38PubMedCrossRef Schwartz A, Sellmeyer D, Ensrud K (2001) Older women with diabetes have an increased risk of fracture: a prospective study. J Clin Endocrinol Metab 86:32–38PubMedCrossRef
68.
go back to reference Vestergaard P (2007) Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes—a meta-analysis. Osteoporos Int 81:427–444CrossRef Vestergaard P (2007) Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes—a meta-analysis. Osteoporos Int 81:427–444CrossRef
69.
go back to reference Janghorbani M, Van Dam RM, Willett WC, Hu FB (2007) Systematic review of Type 1 and Type 2 diabetes mellitus and risk of fracture. Am J Epidemiol 166:495–505PubMedCrossRef Janghorbani M, Van Dam RM, Willett WC, Hu FB (2007) Systematic review of Type 1 and Type 2 diabetes mellitus and risk of fracture. Am J Epidemiol 166:495–505PubMedCrossRef
70.
71.
go back to reference Thrailkill KM, Lumpkin CK Jr, Bunn RC, Kemp SF, Fowlkes JL (2005) Is insulin an anabolic agent in bone? Dissecting the diabetic bone for clues. Am J Physiol Endocrinol Metab 289:E735–E745PubMedCrossRef Thrailkill KM, Lumpkin CK Jr, Bunn RC, Kemp SF, Fowlkes JL (2005) Is insulin an anabolic agent in bone? Dissecting the diabetic bone for clues. Am J Physiol Endocrinol Metab 289:E735–E745PubMedCrossRef
72.
go back to reference Beck TJ, Oreskovic TL, Stone KL, Ruff CB, Ensrud K, Nevitt MC, Genant HK, Cummings SR (2001) Structural adaptation to changing skeletal load in the progression toward hip fragility: the study of osteoporotic fractures. J Bone Miner Res 16:1108–1119PubMedCrossRef Beck TJ, Oreskovic TL, Stone KL, Ruff CB, Ensrud K, Nevitt MC, Genant HK, Cummings SR (2001) Structural adaptation to changing skeletal load in the progression toward hip fragility: the study of osteoporotic fractures. J Bone Miner Res 16:1108–1119PubMedCrossRef
73.
go back to reference Geusens P, Milisen K, Dejaeger E, Boonen S (2003) Falls and fractures in postmenopausal women: a review. J Br Menopause Soc 9:101–106PubMedCrossRef Geusens P, Milisen K, Dejaeger E, Boonen S (2003) Falls and fractures in postmenopausal women: a review. J Br Menopause Soc 9:101–106PubMedCrossRef
74.
go back to reference Weinstein JN, Birkmeyer JD (eds) (2000) The Dartmouth Atlas of Musculoskeletal Health Care. American Hospital Publishing, Chicago, IL Weinstein JN, Birkmeyer JD (eds) (2000) The Dartmouth Atlas of Musculoskeletal Health Care. American Hospital Publishing, Chicago, IL
75.
go back to reference Finkelstein JS, Lee ML, Sowers M, Ettinger B, Neer RM, Kelsey JL, Cauley JA, Huang MH, Greendale GA (2002) Ethnic variation in bone density in premenopausal and early perimenopausal women: effects of anthropometric and lifestyle factors. J Clin Endocrinol Metab 87:3057–3067PubMedCrossRef Finkelstein JS, Lee ML, Sowers M, Ettinger B, Neer RM, Kelsey JL, Cauley JA, Huang MH, Greendale GA (2002) Ethnic variation in bone density in premenopausal and early perimenopausal women: effects of anthropometric and lifestyle factors. J Clin Endocrinol Metab 87:3057–3067PubMedCrossRef
76.
go back to reference Pothiwala P, Evans EM, Chapman-Novakofski KM (2006) Ethnic variation in risk for osteoporosis among women: a review of biological and behavioral factors. J Womens Health (Larchmt) 15:709–719CrossRef Pothiwala P, Evans EM, Chapman-Novakofski KM (2006) Ethnic variation in risk for osteoporosis among women: a review of biological and behavioral factors. J Womens Health (Larchmt) 15:709–719CrossRef
78.
go back to reference Fang J, Freeman R, Jeganathan R, Alderman MH (2004) Variations in hip fracture hospitalization rates among different race/ethnicity groups in New York City. Ethn Dis 14:280–284PubMed Fang J, Freeman R, Jeganathan R, Alderman MH (2004) Variations in hip fracture hospitalization rates among different race/ethnicity groups in New York City. Ethn Dis 14:280–284PubMed
79.
go back to reference Cummings SR, Cauley JA, Palermo L, Ross PD, Wasnich RD, Black D, Faulkner KG (1994) Racial differences in hip axis lengths might explain racial differences in rates of hip fracture. Study of Osteoporotic Fractures Research Group. Osteoporos Int 4:226–229PubMedCrossRef Cummings SR, Cauley JA, Palermo L, Ross PD, Wasnich RD, Black D, Faulkner KG (1994) Racial differences in hip axis lengths might explain racial differences in rates of hip fracture. Study of Osteoporotic Fractures Research Group. Osteoporos Int 4:226–229PubMedCrossRef
80.
go back to reference Brownbill RA, Ilich JZ (2003) Hip geometry and its role in fracture: what do we know so far? Curr Osteoporos Rep 1:25–31PubMedCrossRef Brownbill RA, Ilich JZ (2003) Hip geometry and its role in fracture: what do we know so far? Curr Osteoporos Rep 1:25–31PubMedCrossRef
81.
go back to reference Seeley DG, Kelsey J, Jergas M, Nevitt MC (1996) Predictors of ankle and foot fractures in older women. The Study of Osteoporotic Fractures Research Group. J Bone Miner Res 11:1347–1355PubMedCrossRef Seeley DG, Kelsey J, Jergas M, Nevitt MC (1996) Predictors of ankle and foot fractures in older women. The Study of Osteoporotic Fractures Research Group. J Bone Miner Res 11:1347–1355PubMedCrossRef
82.
go back to reference Hasselman CT, Vogt MT, Stone KL, Cauley JA, Conti SF (2003) Foot and ankle fractures in elderly white women. Incidence and risk factors. J Bone Joint Surg Am 85-A:820–824PubMed Hasselman CT, Vogt MT, Stone KL, Cauley JA, Conti SF (2003) Foot and ankle fractures in elderly white women. Incidence and risk factors. J Bone Joint Surg Am 85-A:820–824PubMed
83.
go back to reference Guggenbuhl P, Meadeb J, Chales G (2005) Osteoporotic fractures of the proximal humerus, pelvis, and ankle: epidemiology and diagnosis. Joint Bone Spine 72:372–375PubMedCrossRef Guggenbuhl P, Meadeb J, Chales G (2005) Osteoporotic fractures of the proximal humerus, pelvis, and ankle: epidemiology and diagnosis. Joint Bone Spine 72:372–375PubMedCrossRef
84.
85.
go back to reference Barrett JA, Baron JA, Karagas MR, ML B (1999) Fracture risk in the U.S. Medicare population. J Clin Epidemiol 52:243–249PubMedCrossRef Barrett JA, Baron JA, Karagas MR, ML B (1999) Fracture risk in the U.S. Medicare population. J Clin Epidemiol 52:243–249PubMedCrossRef
86.
go back to reference Eicheldinger C, Bonito A (2008) More accurate racial and ethnic codes for Medicare administrative data. Health Care Financ Rev 29:27–42PubMed Eicheldinger C, Bonito A (2008) More accurate racial and ethnic codes for Medicare administrative data. Health Care Financ Rev 29:27–42PubMed
Metadata
Title
Clinical and demographic factors associated with fractures among older Americans
Authors
A. J. Taylor
L. C. Gary
T. Arora
D. J. Becker
J. R. Curtis
M. L. Kilgore
M. A. Morrisey
K. G. Saag
R. Matthews
H. Yun
W. Smith
E. Delzell
Publication date
01-04-2011
Publisher
Springer-Verlag
Published in
Osteoporosis International / Issue 4/2011
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-010-1300-8

Other articles of this Issue 4/2011

Osteoporosis International 4/2011 Go to the issue