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Osteoporosis International

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01-01-2011 | Original Article

Vitamin D status and parathyroid hormone in a urban population in Vietnam

Authors: L. T. Ho-Pham, N. D. Nguyen, T. Q. Lai, J. A. Eisman, T. V. Nguyen

Published in: Osteoporosis International | Issue 1/2011

Abstract

Summary

In this cross-sectional study in Vietnam, the prevalence of vitamin D insufficiency was 46% in adult women and 20% in adult men. There was a linear inverse relationship between serum 25(OH)D and PTH concentrations, but there was no threshold of 25(OH)D at which PTH levels plateaued.

Introduction

Vitamin D insufficiency is adversely associated with health outcomes. Vitamin D status in Asian populations is not well documented. This study sought to assess vitamin D status and its relationship to parathyroid hormone in a Vietnamese population.

Methods

This cross-sectional study involved 205 men and 432 women aged 18–87 years, who were randomly sampled from various districts in Ho Chi Minh City (Vietnam) according to a proportional sampling scheme. Serum concentration of 25(OH)D and PTH were measured by the Electrochemiluminescence immunoassay on the Roche Elecsys 10100/201 system (Roche Diagnosis Elecsys). Vitamin D insufficiency was quantified as serum 25(OH)D levels below 30 ng/ml (75 nmol/L).

Results

The average age for men and women was 43.8 ± 18.4 years (mean ± SD) and 47.7 ± 17.1 years, respectively. The mean 25(OH)D concentration in men (36.8 ± 10.2 ng/mL) was significantly higher than in women (30.1 ± 5.9; P < 0.0001). The prevalence of vitamin D insufficiency in men was 20% (41/205) which was significantly lower than in women (46%, 199/432). Age, height and weight were independent predictors of 25(OH)D concentrations, and the three factors explained 15% and 5% of variance in 25(OH)D in men and women, respectively. There was a linear inverse relationship between serum 25(OH)D and PTH concentrations, but there was no threshold of 25(OH)D at which PTH levels plateaued.

Conclusions

These data show that vitamin D insufficiency is common even in tropical region, and that women had a greater risk of vitamin D insufficiency than men. These data suggest that an elevation in PTH cannot be used as a marker for vitamin D deficiency.

Lips P (2006) Vitamin D physiology. Prog Biophys Mol Biol 92:4–8CrossRefPubMed

Holick MF (2005) The vitamin D epidemic and its health consequences. J Nutr 135:2739S–2748SPubMed

Stechschulte SA, Kirsner RS, Federman DG (2009) Vitamin D: bone and beyond, rationale and recommendations for supplementation. Am J Med 122:793–802CrossRefPubMed

Peterlik M, Grant WB, Cross HS (2009) Calcium, vitamin D and cancer. Anticancer Res 29:3687–3698PubMed

Garland CF, Gorham ED, Mohr SB, Garland FC (2009) Vitamin D for cancer prevention: global perspective. Ann Epidemiol 19:468–483CrossRefPubMed

Grant WB (2003) Ecologic studies of solar UV-B radiation and cancer mortality rates. Recent Results Canc Res 164:371–377

Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP (2007) Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Am J Clin Nutr 85:1586–1591PubMed

Alfonso B, Liao E, Busta A, Poretsky L (2009) Vitamin D in diabetes mellitus-a new field of knowledge poised for D-velopment. Diabetes Metab Res Rev 25:417–419CrossRefPubMed

Svoren BM, Volkening LK, Wood JR, Laffel LM (2009) Significant vitamin D deficiency in youth with type 1 diabetes mellitus. J Pediatr 154:132–134CrossRefPubMed

10.

Pittas AG, Lau J, Hu FB, Dawson-Hughes B (2007) The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab 92:2017–2029CrossRefPubMed

11.

Lee JH, O'Keefe JH, Bell D, Hensrud DD, Holick MF (2008) Vitamin D deficiency an important, common, and easily treatable cardiovascular risk factor? J Am Coll Cardiol 52:1949–1956CrossRefPubMed

12.

Zittermann A (2006) Vitamin D and disease prevention with special reference to cardiovascular disease. Prog Biophys Mol Biol 92:39–48CrossRefPubMed

13.

Giovannucci E, Liu Y, Hollis BW, Rimm EB (2008) 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Arch Intern Med 168:1174–1180CrossRefPubMed

14.

Linhartova K, Veselka J, Sterbakova G, Racek J, Topolcan O, Cerbak R (2008) Parathyroid hormone and vitamin D levels are independently associated with calcific aortic stenosis. Circ J 72:245–250CrossRefPubMed

15.

Wang TJ, Pencina MJ, Booth SL, Jacques PF, Ingelsson E, Lanier K, Benjamin EJ, D'Agostino RB, Wolf M, Vasan RS (2008) Vitamin D deficiency and risk of cardiovascular disease. Circulation 117:503–511CrossRefPubMed

16.

Cutolo M, Otsa K (2008) Review: vitamin D, immunity and lupus. Lupus 17:6–10CrossRefPubMed

17.

Merlino LA, Curtis J, Mikuls TR, Cerhan JR, Criswell LA, Saag KG (2004) Vitamin D intake is inversely associated with rheumatoid arthritis: results from the Iowa Women's Health Study. Arthritis Rheum 50:72–77CrossRefPubMed

18.

Munger KL, Zhang SM, O'Reilly E, Hernan MA, Olek MJ, Willett WC, Ascherio A (2004) Vitamin D intake and incidence of multiple sclerosis. Neurology 62:60–65PubMed

19.

Cannell JJ, Vieth R, Umhau JC, Holick MF, Grant WB, Madronich S, Garland CF, Giovannucci E (2006) Epidemic influenza and vitamin D. Epidemiol Infect 134:1129–1140CrossRefPubMed

20.

Lips P (2004) Which circulating level of 25-hydroxyvitamin D is appropriate? J Steroid Biochem Mol Biol 89–90:611–614CrossRefPubMed

21.

Holick MF (2007) Vitamin D deficiency. N Engl J Med 357:266–281CrossRefPubMed

22.

Bouillon RA, Auwerx JH, Lissens WD, Pelemans WK (1987) Vitamin D status in the elderly: seasonal substrate deficiency causes 1, 25-dihydroxycholecalciferol deficiency. Am J Clin Nutr 45:755–763PubMed

23.

Chailurkit LO, Rajatanavin R, Teeraungsikul K, Ongphiphadhanakul B, Puavilai G (1996) Serum vitamin D, parathyroid hormone and biochemical markers of bone turnover in normal Thai subjects. J Med Assoc Thai 79:499–504PubMed

24.

Green TJ, Skeaff CM, Rockell JE, Venn BJ, Lambert A, Todd J, Khor GL, Loh SP, Muslimatun S, Agustina R, Whiting SJ (2008) Vitamin D status and its association with parathyroid hormone concentrations in women of child-bearing age living in Jakarta and Kuala Lumpur. Eur J Clin Nutr 62:373–378CrossRefPubMed

25.

Hawkins RC (2009) 25-OH vitamin D3 concentrations in Chinese, Malays, and Indians. Clin Chem 55:1749–1751CrossRefPubMed

26.

Nakamura K (2006) Vitamin D insufficiency in Japanese populations: from the viewpoint of the prevention of osteoporosis. J Bone Miner Metab 24:1–6CrossRefPubMed

27.

Wat WZ, Leung JY, Tam S, Kung AW (2007) Prevalence and impact of vitamin D insufficiency in southern Chinese adults. Ann Nutr Metab 51:59–64CrossRefPubMed

28.

Yan L, Prentice A, Zhang H, Wang X, Stirling DM, Golden MM (2000) Vitamin D status and parathyroid hormone concentrations in Chinese women and men from north-east of the People's Republic of China. Eur J Clin Nutr 54:68–72CrossRefPubMed

29.

Wacholder S (1986) Binomial regression in GLIM: estimating risk ratios and risk differences. Am J Epidemiol 123:174–184PubMed

30.

R, Development, Core, Team (2008) R: A Language and Environment for Statistical Computing. Available at http://www.r-project.org/ Vienna, Austria

31.

Lips P, Duong T, Oleksik A, Black D, Cummings S, Cox D, Nickelsen T (2001) A global study of vitamin D status and parathyroid function in postmenopausal women with osteoporosis: baseline data from the multiple outcomes of raloxifene evaluation clinical trial. J Clin Endocrinol Metab 86:1212–1221CrossRefPubMed

32.

Mithal A, Wahl DA, Bonjour JP, Burckhardt P, Dawson-Hughes B, Eisman JA, El-Hajj Fuleihan G, Josse RG, Lips P, Morales-Torres J (2009) Global vitamin D status and determinants of hypovitaminosis D. Osteoporos Int 20:1807–1821CrossRefPubMed

33.

Hagenau T, Vest R, Gissel TN, Poulsen CS, Erlandsen M, Mosekilde L, Vestergaard P (2009) Global vitamin D levels in relation to age, gender, skin pigmentation and latitude: an ecologic meta-regression analysis. Osteoporos Int 20:133–140CrossRefPubMed

34.

Nakamura K, Tsugawa N, Saito T, Ishikawa M, Tsuchiya Y, Hyodo K, Maruyama K, Oshiki R, Kobayashi R, Nashimoto M, Yoshihara A, Ozaki R, Okano T, Yamamoto M (2008) Vitamin D status, bone mass, and bone metabolism in home-dwelling postmenopausal Japanese women: Yokogoshi Study. Bone 42:271–277CrossRefPubMed

35.

Kung AW, Lee KK (2006) Knowledge of vitamin D and perceptions and attitudes toward sunlight among Chinese middle-aged and elderly women: a population survey in Hong Kong. BMC Public Health 6:226CrossRefPubMed

36.

Konradsen S, Ag H, Lindberg F, Hexeberg S, Jorde R (2008) Serum 1, 25-dihydroxy vitamin D is inversely associated with body mass index. Eur J Nutr 47:87–91CrossRefPubMed

37.

Parikh SJ, Edelman M, Uwaifo GI, Freedman RJ, Semega-Janneh M, Reynolds J, Yanovski JA (2004) The relationship between obesity and serum 1, 25-dihydroxy vitamin D concentrations in healthy adults. J Clin Endocrinol Metab 89:1196–1199CrossRefPubMed

38.

Reinehr T, de Sousa G, Alexy U, Kersting M, Andler W (2007) Vitamin D status and parathyroid hormone in obese children before and after weight loss. Eur J Endocrinol 157:225–232CrossRefPubMed

39.

Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF (2000) Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 72:690–693PubMed

40.

Heaney RP (2004) Functional indices of vitamin D status and ramifications of vitamin D deficiency. Am J Clin Nutr 80:1706S–1709SPubMed

41.

Chapuy MC, Preziosi P, Maamer M, Arnaud S, Galan P, Hercberg S, Meunier PJ (1997) Prevalence of vitamin D insufficiency in an adult normal population. Osteoporos Int 7:439–443CrossRefPubMed

42.

Souberbielle JC, Cormier C, Kindermans C, Gao P, Cantor T, Forette F, Baulieu EE (2001) Vitamin D status and redefining serum parathyroid hormone reference range in the elderly. J Clin Endocrinol Metab 86:3086–3090CrossRefPubMed

43.

Nakamura K, Nashimoto M, Matsuyama S, Yamamoto M (2001) Low serum concentrations of 25-hydroxyvitamin D in young adult Japanese women: a cross-sectional study. Nutrition 17:921–925CrossRefPubMed

44.

Ho-Pham LT, Nguyen PL, Le TT, Doan TA, Tran NT, Le TA, Nguyen TV (2009) Veganism, bone mineral density, and body composition: a study in Buddhist nuns. Osteoporos Int 20:2087–2093CrossRefPubMed

45.

Leino A, Turpeinen U, Koskinen P (2008) Automated measurement of 25-OH vitamin D3 on the Roche Modular E170 analyzer. Clin Chem 54:2059–2062CrossRefPubMed

46.

Holick MF (2006) Vitamin D: its role in cancer prevention and treatment. Prog Biophys Mol Biol 92:49–59CrossRefPubMed

47.

Holick MF (2008) Diabetes and the vitamin d connection. Curr Diab Rep 8:393–398CrossRefPubMed

48.

Hypponen E, Laara E, Reunanen A, Jarvelin MR, Virtanen SM (2001) Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet 358:1500–1503CrossRefPubMed

49.

Krause R, Buhring M, Hopfenmuller W, Holick MF, Sharma AM (1998) Ultraviolet B and blood pressure. Lancet 352:709–710CrossRefPubMed

50.

Holick MF (2004) Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Am J Clin Nutr 79:362–371PubMed

51.

Melamed ML, Michos ED, Post W, Astor B (2008) 25-hydroxyvitamin D levels and the risk of mortality in the general population. Arch Intern Med 168:1629–1637CrossRefPubMed

52.

Autier P, Gandini S (2007) Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials. Arch Intern Med 167:1730–1737CrossRefPubMed

Title: Vitamin D status and parathyroid hormone in a urban population in Vietnam
Authors: L. T. Ho-Pham
N. D. Nguyen
T. Q. Lai
J. A. Eisman
T. V. Nguyen
Publication date: 01-01-2011
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 1/2011
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-010-1207-4

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Vitamin D status and parathyroid hormone in a urban population in Vietnam

Abstract

Summary

Introduction

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusions

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