Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Osteoporosis International
Published in: Osteoporosis International 10/2010

01-10-2010 | Original Article

Maternal high-fat diet: effects on offspring bone structure

Authors: S. A. Lanham, C. Roberts, T. Hollingworth, R. Sreekumar, M. M. Elahi, F. R. Cagampang, M. A. Hanson, R. O. C. Oreffo

Published in: Osteoporosis International | Issue 10/2010

Login to get access

Abstract

Summary

Peak bone mass is believed to partly be programmed in utero. Mouse dams and offspring were given a high-fat diet and offspring studied as adults. Female offspring from high-fat dams exhibited altered trabecular structure indicative of in utero programming. In utero nutrition has consequences in later life.

Introduction

Epidemiological studies suggest that skeletal growth is programmed during intrauterine and early postnatal life. We hypothesise that development of optimal peak bone mass has, in part, a foetal origin and investigated this using a mouse model of maternal dietary fat excess.

Methods

Offspring from mouse dams fed either standard chow (C) or lifetime high-fat diet (HF) were maintained on a HF diet to adulthood. Femur samples were taken at 30 weeks of age and bone structure, adiposity and strength analysed. Sample sizes were four to six for each sex and each diet group.

Results

Offspring from HF-fed dams showed increased adiposity in the femur in comparison to offspring from C-fed dams. Female offspring from HF dams exhibited altered trabecular structure indicative of in utero programming.

Conclusions

A maternal HF diet during pregnancy increases bone marrow adiposity and alters bone structure in their offspring.
Literature
1.
Gluckman PD, Hanson MA (2004) Living with the past: evolution, development, and patterns of disease. Science 305:1733–1736CrossRefPubMed
2.
Bateson P, Barker DJP, Clutton—Brock T, Deb D, D'Udine B, Foley RA, Gluckman PD, Godfrey KM, Kirkwood T, Lahr MM, McNamara J, Metcalfe NB, Monaghan P, Spencer HG, Sultan SE (2004) Developmental plasticity and human health. Nature 430:419–421CrossRefPubMed
3.
Gluckman PD, Hanson MA, Spencer HG (2005) Predictive adaptive responses and human evolution. Trends Ecol Evol 20:527–533CrossRefPubMed
4.
NIH Consensus Development Panel on Osteoporosis Prevention DaT (2001) Osteoporosis prevention, diagnosis, and therapy. JAMA 285:785–795CrossRef
5.
Ralston SH (1998) Do genetic markers aid in risk assessment? Osteoporos Int 8(Suppl 1):S37–S42PubMed
6.
Cooper C, Cawley M, Bhalla A, Egger P, Ring F, Morton L, Barker DJP (1995) Childhood growth, physical activity, and peak bone mass in women. J Bone Miner Res 10:940–947CrossRefPubMed
7.
Cooper C, Fall C, Egger P, Hobbs R, Eastell R, Barker DJP (1997) Growth in infancy and bone mass in later life. Ann Rheum Dis 56:17–21CrossRefPubMed
8.
Cooper C, Javaid MK, Taylor P, Walker—Bone K, Dennison EM, Arden N (2002) The fetal origins of osteoporotic fracture. Calcif Tissue Int 70:391–394CrossRefPubMed
9.
Fall C, Hindmarsh P, Dennison EM, Kellingray S, Barker DJP, Cooper C (1998) Programming of growth hormone secretion and bone mineral density in elderly men: a hypothesis. J Clin Endocrinol Metab 83:135–139CrossRefPubMed
10.
Weaver CM (2007) Vitamin D, calcium homeostasis, and skeleton accretion in children. J Bone Miner Res 22:V45–V49CrossRefPubMed
11.
Antoniades L, MacGregor AJ, Andrew T, Spector TD (2003) Association of birth weight with osteoporosis and osteoarthritis in adult twins. Rheumatology 42:791–796CrossRefPubMed
12.
Godfrey KM, Barker DJP (2000) Fetal nutrition and adult disease. Am J Clin Nutr 71:1344S–1352SPubMed
13.
Barker DJP (1992) The fetal origins of diseases of old age. Eur J Clin Nutr 46(Suppl 3):S3–S9PubMed
14.
15.
Bianco P, Riminucci M, Gronthos S, Robey PG (2001) Bone marrow stromal stem cells: nature, biology, and potential applications. Stem Cells 19:180–192CrossRefPubMed
16.
Tare RS, Babister JC, Kanczler J, Oreffo ROC (2008) Skeletal stem cells: phenotype, biology and environmental niches informing tissue regeneration. Mol Cell Endocrinol 288:11–21CrossRefPubMed
17.
Parhami F, Jackson S, Tintut Y, Le V, Balucan J, Territo M, Demer L (1999) Atherogenic diet and minimally oxidized low density lipoprotein inhibit osteogenic and promote adipogenic differentiation of marrow stromal cells. J Bone Miner Res 14:2067–2078CrossRefPubMed
18.
Parhami F, Tintut Y, Beamer WG, Gharavi N, Goodman W, Demer L (2001) Atherogenic high-fat diet reduces bone mineralization in mice. J Bone Miner Res 16:182–188CrossRefPubMed
19.
Tang YJ, Sheu WH, Liu PH, Lee WJ, Chen YT (2007) Positive associations of bone mineral density with body mass index, physical activity, and blood triglyceride level in men over 70 years old: a TCVGHAGE study. J Bone Miner Metab 25:54–59CrossRefPubMed
20.
Cui LH, Shin MH, Chung EK, Lee YH, Kweon SS, Park KS, Choi JS (2005) Association between bone mineral densities and serum lipid profiles of pre- and post-menopausal rural women in South Korea. Osteoporos Int 16:1975–1981CrossRefPubMed
21.
Langley-Evans SC, Welham SJM, Jackson AA (1999) Fetal exposure to a maternal low protein diet impairs nephrogenesis and promotes hypertension in the rat. Life Sci 64:965–974CrossRefPubMed
22.
Nwagwu MO, Cook A, Langley-Evans SC (2000) Evidence of progressive deterioration of renal function in rats exposed to a maternal low-protein diet in utero. Br J Nutr 83:79–85PubMed
23.
Torrens C, Brawley L, Anthony FW, Dance CS, Dunn R, Jackson AA, Poston L, Hanson MA (2006) Folate supplementation during pregnancy improves offspring cardiovascular dysfunction induced by protein restriction. Hypertension 47:982–987CrossRefPubMed
24.
Mehta G, Roach HI, Langley-Evans SC, Taylor P, Reading I, Oreffo ROC, Aihie-Sayer A, Clarke NM, Cooper C (2002) Intrauterine exposure to a maternal low protein diet reduces adult bone mass and alters growth plate morphology in rats. Calcif Tissue Int 71:493–498CrossRefPubMed
25.
Khan IY, Dekou V, Douglas G, Jensen R, Hanson MA, Poston L, Taylor PD (2005) A high-fat diet during rat pregnancy or suckling induces cardiovascular dysfunction in adult offspring. Am J Physiol Regul Integr Comp Physiol 288:R127–R133PubMed
26.
Bayol SA, Simbi BH, Stickland NC (2005) A maternal cafeteria diet during gestation and lactation promotes adiposity and impairs skeletal muscle development and metabolism in rat offspring at weaning. J Physiol (Lond) 567:951–961CrossRef
27.
Elahi MM, Cagampang FR, Mukhtar D, Anthony FW, Ohri SK, Hanson MA (2009) Long-term maternal high-fat feeding from weaning through pregnancy and lactation predisposes offspring to hypertension, raised plasma lipids and fatty liver in mice. Br J Nutr 101:1463–1466CrossRef
28.
Cleal JK, Poore KR, Boullin JP, Khan O, Chau R, Hambidge O, Torrens C, Newman JP, Poston L, Noakes DE, Hanson MA, Green LR (2007) Mismatched pre- and postnatal nutrition leads to cardiovascular dysfunction and altered renal function in adulthood. Proc Natl Acad Sci USA 104:9529–9533CrossRefPubMed
29.
Jasienska G, Thune I, Ellison PT (2006) Fatness at birth predicts adult susceptibility to ovarian suppression: an empirical test of the predictive adaptive response hypothesis. Proc Natl Acad Sci USA 103:12759–12762CrossRefPubMed
30.
Khan IY, Dekou V, Hanson MA, Poston L, Taylor P (2004) Predictive adaptive responses to maternal high-fat diet prevent endothelial dysfunction but not hypertension in adult rat offspring. Circulation 110:1097–1102CrossRefPubMed
31.
Lanham SA, Roberts C, Cooper C, Oreffo ROC (2008) Intrauterine programming of bone. Part 1: alteration of the osteogenic environment. Osteoporos Int 19:147–156CrossRefPubMed
32.
Lanham SA, Roberts C, Perry M, Cooper C, Oreffo ROC (2008) Intrauterine programming of bone. Part 2: alteration of skeletal structure. Osteoporos Int 19:157–167CrossRefPubMed
33.
Hildebrand T, Rüegsigger P (1997) Quantification of bone microarchitecture with the structure model index. Comput Methods Biomech Biomed Eng 1:15–23CrossRef
34.
Chappard D, Legrand E, Haettich N, Chales G, Auvinet B, Eschard JP, Hamelin JP, Basle MF, Audran M (2001) Fractal dimension of trabecular bone: comparison of three histomorphometric computed techniques for measuring the architectural two-dimensional complexity. J Pathol 195:515–521CrossRefPubMed
35.
Hahn M, Vogel M, Pompesiuskempa M, Delling G (1992) Trabecular bone pattern factor—a new parameter for simple quantification of bone microarchitecture. Bone 13:327–330CrossRefPubMed
36.
Odgaard A (1997) Three-dimensional methods for quantification of cancellous bone architecture. Bone 20:315–328CrossRefPubMed
37.
Chechi K, McGuire JJ, Cheema SK (2009) Developmental programming of lipid metabolism and aortic vascular function in C57BL/6 mice: a novel study suggesting an involvement of LDL-receptor. Am J Physiol Regul Integr Comp Physiol 296:R1029–R1040PubMed
38.
Sellayah D, Sek K, Anthony FW, Watkins AJ, Osmond C, Fleming TP, Hanson MA, Cagampang FR (2008) Appetite regulatory mechanisms and food intake in mice are sensitive to mismatch in diets between pregnancy and postnatal periods. Brain Res 1237:146–152CrossRefPubMed
39.
Gallou-Kabani C, Vige A, Gross MS, Boileau C, Rabes JP, Fruchart-Najib J, Jais JP, Junien C (2007) Resistance to high-fat diet in the female progeny of obese mice fed a control diet during the periconceptual, gestation, and lactation periods. Am J Physiol Endocrinol Metab 292:E1095–E1100CrossRefPubMed
40.
Khan IY, Taylor PD, Dekou V, Seed PT, Lakasing L, Graham D, Dominiczak AF, Hanson MA, Poston L (2003) Gender-linked hypertension in offspring of lard-fed pregnant rats. Hypertension 41:168–175CrossRefPubMed
41.
Elahi MM, Cagampang FR, Mukhtar D, Anthony FW, Ohri SK, Hanson MA (2009) Long-term maternal high-fat feeding from weaning through pregnancy and lactation predisposes offspring to hypertension, raised plasma lipids and fatty liver in mice. Br J Nutr 102:514–519CrossRefPubMed
42.
Atteh JO, Leeson S, Julian RJ (1983) Effects of dietary levels and types of fat on performance and mineral metabolism of broiler chicks. Poult Sci 62:2403–2411PubMed
43.
Atteh JO, Leeson S (1984) Effects of dietary saturated or unsaturated fatty-acids and calcium levels on performance and mineral metabolism of broiler chicks. Poult Sci 63:2252–2260PubMed
Metadata
Title
Maternal high-fat diet: effects on offspring bone structure
Authors
S. A. Lanham
C. Roberts
T. Hollingworth
R. Sreekumar
M. M. Elahi
F. R. Cagampang
M. A. Hanson
R. O. C. Oreffo
Publication date
01-10-2010
Publisher
Springer-Verlag
Published in
Osteoporosis International / Issue 10/2010
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-009-1118-4

Other articles of this Issue 10/2010

Osteoporosis International 10/2010 Go to the issue

Review

A systematic review of interventions by healthcare professionals on community-dwelling postmenopausal women with osteoporosis

Perspective

“Evidence-based” or “logic-based” medicine?

Original Article

A single dose of zoledronic acid reverses the deleterious effects of glucocorticoids on titanium implant osseointegration

Original Article

Novel ultrasonic bone densitometry based on two longitudinal waves: significant correlation with pQCT measurement values and age-related changes in trabecular bone density, cortical thickness, and elastic modulus of trabecular bone in a normal Japanese population

Original Article

Outdoor air pollution, bone density and self-reported forearm fracture: the Oslo Health Study

Original Article

Persistence and switching patterns among women with varied osteoporosis medication histories: 12-month results from POSSIBLE US™