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Osteoporosis International

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01-06-2010 | Original Article

Longitudinal changes in femur bone mineral density after spinal cord injury: effects of slice placement and peel method

Authors: S. Dudley-Javoroski, R. K. Shields

Published in: Osteoporosis International | Issue 6/2010

Abstract

Summary

Surveillance of femur metaphysis bone mineral density (BMD) decline after spinal cord injury (SCI) may be subject to slice placement error of 2.5%. Adaptations to anti-osteoporosis measures should exceed this potential source of error. Image analysis parameters likewise affect BMD output and should be selected strategically in longitudinal studies.

Introduction

Understanding the longitudinal changes in bone mineral density (BMD) after spinal cord injury (SCI) is important when assessing new interventions. We determined the longitudinal effect of SCI on BMD of the femur metaphysis. To facilitate interpretation of longitudinal outcomes, we (1) determined the BMD difference associated with erroneous peripheral quantitative computed tomography (pQCT) slice placement, and (2) determined the effect of operator-selected pQCT peel algorithms on BMD.

Methods

pQCT images were obtained from the femur metaphysis (12% of length from distal end) of adult subjects with and without SCI. Slice placement errors were simulated at 3 mm intervals and were processed in two ways (threshold-based vs. concentric peel).

Results

BMD demonstrated a rapid decline over 2 years post-injury. BMD differences attributable to operator-selected peel methods were large (17.3% for subjects with SCI).

Conclusions

Femur metaphysis BMD declines after SCI in a manner similar to other anatomic sites. Concentric (percentage-based) peel methods may be most appropriate when special sensitivity is required to detect BMD adaptations. Threshold-based methods may be more appropriate when asymmetric adaptations are observed.

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Title: Longitudinal changes in femur bone mineral density after spinal cord injury: effects of slice placement and peel method
Authors: S. Dudley-Javoroski
R. K. Shields
Publication date: 01-06-2010
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 6/2010
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-009-1044-5

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Longitudinal changes in femur bone mineral density after spinal cord injury: effects of slice placement and peel method

Abstract

Summary

Introduction

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusions

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