Top

Osteoporosis International

Published in:

01-03-2010 | Original Article

The relationship between low bone mass and metabolic syndrome in Korean women

Authors: D.-K. Hwang, H.-J. Choi

Published in: Osteoporosis International | Issue 3/2010

Abstract

Summary

We examined the relationship between low bond mass and metabolic syndrome in 2,475 Korean women. After adjustment for all covariates, mean vertebral BMD was significantly lower in women with metabolic syndrome. Moreover, age and weight adjusted vertebral BMD was significantly decreased with additional components of the metabolic syndrome.

Introduction

Obesity-induced chronic inflammation is a key component in the pathogenesis of insulin resistance and metabolic syndrome. It has been suggested that proinflammatory cytokines and low-grade systemic inflammation activate bone resorption and may lead to reduced bone mineral density (BMD). The objective of this study was to determine the relationship between low bone mass and metabolic syndrome in Korean women.

Methods

This is a cross-sectional study of 2,548 women aged 18 years and over who had visited the Health Promotion Center. Physical examination and laboratory tests were performed. Vertebral BMD was measured using dual-energy X-ray absorptiometry. Metabolic syndrome was defined by National Cholesterol Education Program—Adult Treatment Panel III criteria.

Results

Among 2,475 women, 511 (21.0%) women had metabolic syndrome. Women with abdominal obesity or hypertriglyceridemia had significantly lower vertebral BMD than women without respective components after adjustment for age, weight, and height. After adjustment for all covariates, mean vertebral BMD was significantly lower in women with metabolic syndrome (p = 0.031). Moreover, age- and weight-adjusted vertebral BMD were significantly decreased with additional components of the metabolic syndrome (p = 0.004).

Conclusions

These findings suggest that metabolic syndrome might be another risk factor for osteoporosis and related fractures.

Anonymous (1993) Consensus development conference: diagnosis, prophylaxis and treatment of osteoporosis. Am J Med 941:646–650

Cooper C, Atkinson EJ, Jacobsen SJ, O'Fallon WM, Melton LJ 3rd (1993) Population-based study of survival after osteoporotic fractures. Am J Epidemiol 137(9):1001–1005PubMed

Chrischilles EA, Butler CD, Davis CS, Wallace RB (1991) A model of lifetime osteoporosis impact. Arch Intern Med 151(10):2026–2032CrossRefPubMed

Deen D (2004) Metabolic syndrome: time for action. Am Fam Physician 69(12):2875–2882PubMed

Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (2001) Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA 285(19):2486–2497CrossRef

Ford ES, Giles WH, Dietz WH (2002) Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutritional Examination Survey. JAMA 287:356–359CrossRefPubMed

Kim MH, Kim MK, Choi BY, Shin YJ (2004) Prevalence of the metabolic syndrome and its association with cardiovascular diseases in Korea. J Korean Med Sci 19:195–201PubMed

Kinjo M, Setoguchi S, Solomon DH (2007) Bone mineral density in adults with the metabolic syndrome: analysis in a population-based U.S. sample. J Clin Endocrinol Metab 92:4161–4164CrossRefPubMed

Ahmed LA, Schirmer H, Berntsen GK, Fonnebo V, Joakimsen RM (2006) Features of the metabolic syndrome and the risk of non-vertebral fractures: the Tromso study. Osteoporos Int 16:1899–1906

10.

Ganesan K, Teklehaimanot S, Tran TH, Asuncion M, Norris K (2005) Relationship of C-reactive protein and bone mineral density in community-dwelling elderly females. J Natl Med Assoc 97:329–333PubMed

11.

Schett G, Kiechl S, Weger S, Pederiva A, Mayr A, Petangeli M, Oberhollenzer F, Lorenzini R, Redlich K, Axmann R, Zwerina J, Willeit J (2006) High-sensitivity C-reactive protein and risk of nontraumatic fractures in the Bruneck Study. Arch Intern Med 166:2495–2501CrossRefPubMed

12.

Zhao L-J, Liu Y-J, Liu P-Y, Hamilton J, Recker RR, Deng H-W (2007) Relationship of obesity and osteoporosis. J Clin Endocrinol Metab 92:1640–1646CrossRefPubMed

13.

World Health Organization (1995) Physicial status; the use and interpretation of anthropometry. Technical report series 854. WHO, Geneva

14.

WHO Western Pacific Region, IASO and IOTF (2000) The Asia-pacific perspective: redefining obestity and its treatment, Sydney, Australia, Health Communications Australia Pty Limit

15.

The expert committee on the diagnosis and classification of diabetes mellitus (2003) Follow-up on the diagnosis of diabetes mellitus. Diabetes Care 26(11):3160–3167CrossRef

16.

Lee WY, Park JS, Noh SY, Rhee EJ, Sung KC, Kim BS, Kang JH, Kim SW, Lee MH, Park JR (2004) C-reactive protein concentrations are related to insulin resistance and metabolic syndrome as defined by the ATP III report. Int J Cardiol 97(1):101–106CrossRefPubMed

17.

Diamant M, Lamb HJ, van de Ree MA, Endert EL, Groeneveld Y, Bots ML, Kostense PJ, Radder JK (2005) The association between abdominal visceral fat and carotid stiffness is mediated by circulating inflammatory markers in uncomplicated type 2 diabetes. J Clin Endocrinol Metab 90(3):1495–1501CrossRefPubMed

18.

Cleland SJ, Petrie JR, Small M, Elliott HL, Connell JM (2000) Insulin action is associated with endothelial function in hypertension and type2 diabetes. Hypertension 35:507–511PubMed

19.

Pepys MB, Baltz ML (1983) Acute phase proteins with special reference to C-reactive protein and related proteins (pentaxins) and serum amyloid A protein. Adv Immunol 34:141–212CrossRefPubMed

20.

Fröhlich M, Imhof A, Berg G, Hutchinson WL, Pepys MB, Boeing H, Muche R, Brenner H, Koenig W (2000) Association between C-reactive protein and features of the metabolic syndrome: a population-based study. Diabetes Care 23:1835–1839CrossRefPubMed

21.

Chambers JC, Eda S, Bassett P, Karim Y, Thompson SG, Gallimore JR, Pepys MB, Kooner JS (2001) C-reactive protein, insulin resistance, central obesity, and coronary heart disease risk in Indian Asians from the United Kingdom compared with European whites. Circulation 104:145–150PubMed

22.

Ford ES (1999) Body mass index, diabetes, and C-reactive protein among U.S. adults. Diabetes Care 22:1971–1977CrossRefPubMed

23.

Yudkin JS, Stehouwer CDA, Emeis JJ, Coppack SW (1999) C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction. A potential role for cytokines originating from adipose tissue? Arterioscler Thromb Vasc Biol 19:972–978PubMed

24.

von Muhlen D, Safii S, Kassal SK, Svartberg J, Barrett-Conner E (2007) Associations between the metabolic syndrome and bone health in older men and women: the Rancho Bernardo Study. Osteoporos Int 18:1337–1344CrossRef

25.

Zhao LJ, Liu YJ, Liu PY, Hamilton LJ, Recker RR, Deng HW (2007) Relationship of obesity with osteoporosis. J Clin Endocrinol Metab 92:1640–1646CrossRefPubMed

26.

Felson DT, Zhang Y, Hannan MT, Anderson JJ (1993) Effects of weight and body mass index on bone mineral density in men and women: the Framingham study. J Bone Miner Res 8(5):567–573CrossRefPubMed

27.

Marcus R, Greendale G, Blunt BA, Bush TL, Sherman S, Sherwin R, Wahner H, Wells B (1994) Correlates of bone mineral density in the postmenopausal estrogen/progestin interventions trial. J Bone Miner Res 9(9):1467–1476CrossRefPubMed

28.

Ravn P, Cizza G, Bjarnason NH, Thompson D, Daley M, Wasnich RD, McClung M, Hosking D, Yates AJ, Christiansen C (1999) Low body mass index is an important risk factor for low bone mass and increased bone loss in early postmenopausal women. J Bone Miner Res 14(9):1622–1627CrossRefPubMed

29.

De Laet C, Kanis JA, Odén A, Johanson H, Johnell O, Delmas P, Eisman JA, Kroger H, Fujiwara S, Garnero P, McCloskey EV, Mellstrom D, Melton LJ 3rd, Meunier PJ, Pols HA, Reeve J, Silman A, Tenenhouse A (2005) Body mass index as a predictor of fracture risk: a meta-analysis. Osteoporos Int 16(11):1330–1338CrossRefPubMed

30.

Barrett-Connor E, Kritz-Silverstein D (1996) Dose hyperinsulinemia preserve bone? Diabetes Care 19(12):1388–1392CrossRefPubMed

31.

McLaughlin T, Abbasi F, Lamendola C, Liang L, Reaven G, Schaaf P, Reaven P (2002) Differentiation between obesity and insulin resistance in the association with C-reactive protein. Circulation 106:2908–2912CrossRefPubMed

32.

Rhee EJ, Kim YC, Lee WY, Jung CH, Sung KC, Ryu SH, Oh KW, Kim SW (2006) Comparison of insulin resistance and serum high-sensitivity C-reactive protein levels according to the fasting blood glucose subgroups divided by the newly recommended criteria for fasting hyperglycemia in 10059 healthy Koreans. Metabolism 55:183–187CrossRefPubMed

33.

Koh JM, Khang YH, Jung CH, Bae S, Kim DJ, Chung YE, Kim GS (2005) Higher circulating hsCRP levels are associated with lower bone mineral density in healthy pre- and postmenopausal women: evidence for a link between systemic inflammation and osteoporosis. Osteoporos Int 16:1263–1271CrossRefPubMed

Title: The relationship between low bone mass and metabolic syndrome in Korean women
Authors: D.-K. Hwang
H.-J. Choi
Publication date: 01-03-2010
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 3/2010
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-009-0990-2

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

The relationship between low bone mass and metabolic syndrome in Korean women

Abstract

Summary

Introduction

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 3/2010

Association between vitamin D receptor gene polymorphisms, falls, balance and muscle power: results from two independent studies (APOSS and OPUS)

Relationship between the mandibular inferior cortex and bone stiffness in elderly Japanese people

Osteonecrosis of the jaw induced by oral administration of bisphosphonates in Asian population: five cases

Does inadequate diet during childhood explain the higher high fracture rates in the Southern United States?

Height loss in elderly women is preceded by osteoporosis and is associated with digestive problems and urinary incontinence

Use of risedronate to prevent bone loss following a single course of glucocorticoids: findings from a proof-of-concept study in inflammatory bowel disease