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Osteoporosis International

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01-03-2010 | Short Communication

High-resolution peripheral QCT imaging of bone micro-structure in adolescents

Authors: M. Burrows, D. Liu, H. McKay

Published in: Osteoporosis International | Issue 3/2010

Abstract

Summary

We examined the feasibility of high-resolution peripheral quantitative computed tomography (HR-pQCT) to assess bone microstructure in adolescents. Low radiation doses and clear images were produced using a region of interest (ROI) at 8% of tibial length. Active growth plates were observed in 33 participants. HR-pQCT safely assessed important elements of bone microstructure in adolescents.

Introduction

We examined the feasibility and safety of HR-pQCT to assess tibial bone microstructure in adolescents.

Methods

We used XtremeCT (Scanco Medical) to assess bone microstructure at the distal tibia in 278 participants (15–20 years old).

Results

The 2.8-min scan resulted in a relatively low radiation dose (<3 µSv) while producing artifact clear images in all participants. An 8% scan site was equivalent to 33 ± 2 mm of total tibial length (400 ± 30 mm). We observed active growth plates in 33 participants. The growth plate was located at 13 ± 2 mm of total tibial length and was not included in the ROI for any participant.

Conclusions

HR-pQCT safely assessed important elements of bone microstructure in adolescents. Given the important contribution of bone geometry and structure to bone strength, it is essential to better understand the development and adaptation of these parameters in cortical and trabecular bone compartments.

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Title: High-resolution peripheral QCT imaging of bone micro-structure in adolescents
Authors: M. Burrows
D. Liu
H. McKay
Publication date: 01-03-2010
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 3/2010
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-009-0913-2

At a glance: The STEP trials

Springer Medicine

High-resolution peripheral QCT imaging of bone micro-structure in adolescents

Abstract

Summary

Introduction

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusions

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