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Osteoporosis International

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Open Access 01-12-2009 | Original Article

Peripheral arterial disease and osteoporosis in older adults: the Rancho Bernardo Study

Authors: D. von Mühlen, M. Allison, S. K. Jassal, E. Barrett-Connor

Published in: Osteoporosis International | Issue 12/2009

Abstract

Summary

We examined the association between peripheral arterial disease (PAD) and bone health in 1,332 adults. We found a weak association between PAD and osteoporosis and bone loss only in women, but the association was not independent of age. PAD was not associated with fractures in this community-based population.

Introduction

Increased rates of osteoporosis have been reported in patients with cardiovascular disease, suggesting a link between osteoporosis and atherosclerosis.

Methods

We examined the association between PAD and bone health in 1,332 adults who attended a research visit in 1992–1996, when the ankle–brachial index (ABI), bone mineral density (BMD), and spine X-rays were obtained. A total of 837 participants attended a follow-up visit in 1997–2000.

Results

PAD defined by an ABI ≤ 0.90 was present in 15.4% of the women and 13.3% of the men. Prevalence of osteoporosis was significantly higher in women with PAD compared to women without PAD (p < 0.05). During an average 4-year follow-up, women with PAD had a significantly higher rate of bone loss than women without PAD (p = 0.05). The associations were no longer significant after age adjustment. In men, PAD was not associated with osteoporosis, but men with PAD had lower BMD at the femoral neck than men without PAD (p = 0.03). PAD was not associated with osteoporotic fractures in either sex.

Conclusion

We found a weak and age-dependent association between PAD and osteoporosis in women but not men. PAD was not associated with fractures in this community-based population.

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Title: Peripheral arterial disease and osteoporosis in older adults: the Rancho Bernardo Study
Authors: D. von Mühlen
M. Allison
S. K. Jassal
E. Barrett-Connor
Publication date: 01-12-2009
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 12/2009
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-009-0912-3

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Peripheral arterial disease and osteoporosis in older adults: the Rancho Bernardo Study

Abstract

Summary

Introduction

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusion

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