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Osteoporosis International

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Open Access 01-12-2009 | Original Article

Morphological changes of injected calcium phosphate cement in osteoporotic compressed vertebral bodies

Authors: D. H. Heo, Y. J. Cho, S. H. Sheen, S. U. Kuh, S. M. Cho, S. M. Oh

Published in: Osteoporosis International | Issue 12/2009

Abstract

Summary

This study was undertaken to investigate the radiologic and clinical outcomes of vertebroplasty with calcium phosphate (CaP) cement in patients with osteoporotic vertebral compression fractures. The morphological changes of injected CaP cement in osteoporotic compressed vertebral bodies were variable and unpredictable. We suggest that the practice of vertebroplasty using CaP should be reconsidered.

Introduction

Recently, CaP, an osteoconductive filler material, has been used in the treatment of osteoporotic compression fractures. However, the clinical results of CaP-cement-augmented vertebrae are still not well established. The purpose of this study is to assess the clinical results of vertebroplasty with CaP by evaluating the morphological changes of CaP cement in compressed vertebral bodies.

Methods

Fourteen patients have been followed for more than 2 years after vertebroplasty. The following parameters were reviewed: age, sex, T score, compliance with osteoporosis medications, visual analog scale score, compression ratio, subsequent compression fractures, and any morphological changes in the filler material.

Results

The morphological changes of injected CaP included reabsorption, condensation, bone formation (osteogenesis), fracture of the CaP solid hump, and heterotopic ossification. Out of 14 patients, 11 (78.6%) developed progression of the compression of the CaP-augmented vertebral bodies after vertebroplasty.

Conclusions

The morphological changes of the injected CaP cement in the vertebral bodies were variable and unpredictable. The compression of the CaP-augmented vertebrae progressed continuously for 2 years or more. The findings of this study suggest that vertebroplasty using CaP cement should be reconsidered.

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Title: Morphological changes of injected calcium phosphate cement in osteoporotic compressed vertebral bodies
Authors: D. H. Heo
Y. J. Cho
S. H. Sheen
S. U. Kuh
S. M. Cho
S. M. Oh
Publication date: 01-12-2009
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 12/2009
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-009-0911-4

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Springer Medicine

Morphological changes of injected calcium phosphate cement in osteoporotic compressed vertebral bodies

Abstract

Summary

Introduction

Methods

Results

Conclusions

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Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusions

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