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Osteoporosis International

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01-10-2009 | Original Article

Determinants of 25-hydroxyvitamin D levels in African-American and Caucasian male veterans

Authors: A. Benjamin, A. Moriakova, N. Akhter, D. Rao, H. Xie, S. Kukreja, E. Barengolts

Published in: Osteoporosis International | Issue 10/2009

Abstract

Summary

Among 307 males seen in VA Medical Center, independent determinants (p < 0.01 for all) of serum 25-hydroxyvitamin D [25(OH)D] levels included race, vitamin D supplements, BMI, dietary calcium intake and smoking, but not age. Negative association between 25(OH)D and parathyroid hormone (PTH) was similar for Caucasian and African-American men.

Introduction

In this prospective cohort study, we examined determinants of serum 25-hydroxyvitamin D [25(OH)D] levels and the relationship between 25(OH)D and PTH levels and body mass index (BMI).

Methods

Male veterans (n = 307) were recruited at a VA Medical Center. Serum levels of PTH and 25(OH)D were obtained. Surveys and chart reviews were completed. Vitamin D insufficiency was defined as 25(OH)D <30 ng/ml. Univariate and multivariate regression analyses were performed.

Results

Among 232 African-American (AA) men (mean ± SD), 25(OH)D level (21.4 ± 10.4 ng/ml) was lower and prevalence of insufficiency (80%) was higher than among 75 Caucasians (C; 28.5 ± 11.1 ng/ml and 53%, respectively, p < 0.01 for both). In multivariate regression analysis, independent determinants (p < 0.01 for all) of 25(OH)D levels included AA race, vitamin D supplements, BMI, dietary calcium intake, and smoking. Despite lower 25(OH)D levels in African-Americans, PTH levels were similar to those seen in Caucasians. There was a significant (p < 0.02) negative linear association between 25(OH)D and PTH in African-American (r ² = 0.05) and Caucasian (r ² = 0.08) men, and there was no difference between the slopes of the relationship.

Conclusions

25(OH)D levels are determined by modifiable risk factors such as vitamin D supplementation in both AA and C males. The negative association between 25(OH)D and PTH is similar between the two races.

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Title: Determinants of 25-hydroxyvitamin D levels in African-American and Caucasian male veterans
Authors: A. Benjamin
A. Moriakova
N. Akhter
D. Rao
H. Xie
S. Kukreja
E. Barengolts
Publication date: 01-10-2009
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 10/2009
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-009-0873-6

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Determinants of 25-hydroxyvitamin D levels in African-American and Caucasian male veterans

Abstract

Summary

Introduction

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusions

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