Top

Published in:

01-06-2009 | Bone Quality Seminars: Ultrastructure

Effects of bone anabolic agents on bone ultrastructure

Author: B. Cortet

Published in: Osteoporosis International | Issue 6/2009

Excerpt

Currently, several effective anti-osteoporotic drugs are available, and their mechanisms of action are well known, albeit widely varying depending on the nature of the drugs involved. This paper addresses the following questions: Firstly, to what extent do these molecules and their mechanisms of action account for their antifracture efficacy? Secondly, it is known that changes in the values of intermediate parameters (BMD, bone remodelling markers) during treatment only partially account for the antifracture efficacy of these drugs. …

Chen P, Miller PD, Recker R, Resch H, Rana A, Pavo I, Sipos AA (2007) Increases in BMD correlate with improvements in bone microarchitecture with teriparatide treatment in postmenopausal women with osteoporosis. J Bone Minere Res 22:1173–1180CrossRef

Paschalis EP, Glass EV, Donley DW, Eriksen EF (2005) Bone mineral and collagen quality in iliac crest biopsies of patients given teriparatide: new results from the fracture prevention trial. J Clin Endocrinol Metab 90:4644–4649PubMedCrossRef

Misof BM, Roschger P, Cosman F, Kurland ES, Tesch W, Messmer P, Dempster DW et al (2003) Effects of intermittent parathyroid hormone administration on bone mineralization density in iliac crest biopsies from patients with osteoporosis: a paired study before and after treatment. J Clin Endocrinol Metab 88:1150–1156PubMedCrossRef

Garnero P, Bauer DC, Mareau E, Bilezikian JP, Greenspan SL, Rosen C, Black D. Effects of parathyroid hormone and alendronate on type 1 collagen isomerization in postmenopausal women with osteoporosis: the PaTH study. J Bone Mineral Res 2008 [Epubahead of print]

Boivin G, Deloffre P, Perrat B, Panczer B, Boudeulle M, Mauras Y et al (1996) Strontium distribution and interactions with bone mineral in monkey iliac bone after strontium salt (S 12911) administration. J Bone Miner Res 11:1302–1311PubMedCrossRef

Farlay D, Boivin G, Panczer G, Lalande A, Meunier PJ (2005) Long-term strontium ranelate administration in monkeys preserves characteristics of bone mineral crystals and degree of mineralization of bone. J Bone Miner Res 20:1569–1578PubMedCrossRef

Amman P, Badoud I, Barraud S, Dayer R, Rizzoli R (2007) Strontium ranelate treatment improves trabecular and cortical intrinsic bone tissue quality, a determinant of bone strength. J Bone Miner Res 22:1419–1425CrossRef

Boivin G (2007) The hydroxyapatite crystal: a closer look. Medicographia 29:126–132

Title: Effects of bone anabolic agents on bone ultrastructure
Author: B. Cortet
Publication date: 01-06-2009
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 6/2009
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-009-0862-9

ACC 2024 Congress

Springer Medicine

Effects of bone anabolic agents on bone ultrastructure

Excerpt

ACC 2024 Congress

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Issue 6/2009

The health-related quality of life and cost implications of falls in elderly women

Epidemiology of lumbar osteoporosis and osteoarthritis and their causal relationship—is osteoarthritis a predictor for osteoporosis or vice versa?: The Miyama study

Influence of remodeling on the mineralization of bone tissue

Genetic and environmental determinants on bone loss in postmenopausal Caucasian women: a 14-year longitudinal twin study

Poor glycemic control is associated with low BMD detected in premenopausal women with type 1 diabetes

Investigation of bone with synchrotron radiation imaging: from micro to nano