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01-08-2009 | Original Article

Effects of lean and fat mass on bone mineral density and arterial stiffness in elderly men

Authors: A. Benetos, A. Zervoudaki, A. Kearney-Schwartz, C. Perret-Guillaume, V. Pascal-Vigneron, P. Lacolley, C. Labat, G. Weryha

Published in: Osteoporosis International | Issue 8/2009

Abstract

Summary

The role of body composition on arterial stiffness and osteoporosis remains unclear, especially in the elderly male population. Our results indicate that elderly men with high lean mass and low fat mass exhibit the best arterial and bone profile with the lowest arterial stiffness and the highest bone mineral density.

Introduction

The aim of this study was to evaluate the influence of fat and lean mass on both arterial stiffness and bone mass density (BMD) in elderly men.

Methods

This study was performed in 169 French males over 60 years old. Aortic stiffness was assessed by carotid/femoral pulse wave velocity (PWV). BMD and body composition were determined with a dual-energy X-ray absorptiometry device in the lumbar spine L1–L4, femoral neck, and total body.

Results

Lean mass was positively correlated with the three T scores accounting for 11.6%, 26.6%, and 12.2% of the variability in the lumbar spine L1–L4, femoral neck, and total body BMD T scores, respectively. Fat mass had no effect on BMD. However, fat mass was positively correlated with aortic PWV, accounting for 9.8% of its variability. Lean mass was not a determinant of PWV. Hypertension, diabetes, and dyslipidemia were associated with higher PWV but had no effect on BMD.

Conclusions

In males from a general population over 60 years of age, bone and arterial aging are differently influenced by lean and fat mass. Our results indicate that elderly men with high lean mass and low fat mass exhibit the best arterial and bone profile with the lowest arterial stiffness and the highest BMD.

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Title: Effects of lean and fat mass on bone mineral density and arterial stiffness in elderly men
Authors: A. Benetos
A. Zervoudaki
A. Kearney-Schwartz
C. Perret-Guillaume
V. Pascal-Vigneron
P. Lacolley
C. Labat
G. Weryha
Publication date: 01-08-2009
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 8/2009
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-008-0807-8

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Effects of lean and fat mass on bone mineral density and arterial stiffness in elderly men

Abstract

Summary

Introduction

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusions

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