Skip to main content
Top
Published in: Osteoporosis International 6/2007

01-06-2007 | Case Report

Hepatotoxicity induced by alendronate therapy

Authors: B. Yanık, C. Turkay, H. Atalar

Published in: Osteoporosis International | Issue 6/2007

Login to get access

Abstract

Here we describe a 47-year-old postmenopausal woman who had been taking alendronate 70 mg/week for osteoporosis. After two months of alendronate therapy, she developed hepatotoxicity, and no other etiological factors for this besides the alendronate were apparent. After the alendronate therapy was discontinued, the patient’s hepatic enzyme levels slowly returned to normal. Hepatotoxicity due to alendronate therapy is a rare but possible adverse effect.
Literature
1.
go back to reference Peter C, Rodan GA (1999) Preclinical safety profile of alendronate. Int J Clin Pract Suppl 101:3–8PubMed Peter C, Rodan GA (1999) Preclinical safety profile of alendronate. Int J Clin Pract Suppl 101:3–8PubMed
2.
go back to reference Felsenberg D, Alenfeld F, Bock O, Hammermeister C, Gowan W (1998) Placebo-controlled multicenter study of oral alendronate in postmenopausal osteoporotic women. FOSIT-Study-Group. Fosamax International Trial. Maturitas 31:35–44PubMedCrossRef Felsenberg D, Alenfeld F, Bock O, Hammermeister C, Gowan W (1998) Placebo-controlled multicenter study of oral alendronate in postmenopausal osteoporotic women. FOSIT-Study-Group. Fosamax International Trial. Maturitas 31:35–44PubMedCrossRef
3.
go back to reference Watts N, Freedholm D, Daifotis A (1999) Alendronate: from the laboratory to the patient: the clinical tolerability profile of alendronate. Int J Clin Pract 101:51–61 Watts N, Freedholm D, Daifotis A (1999) Alendronate: from the laboratory to the patient: the clinical tolerability profile of alendronate. Int J Clin Pract 101:51–61
4.
go back to reference Eisman JA, Rizzoli R, Roman-Ivorra J, Lipschitz S, Verbruggen N, Gaines KA, Melton ME (2004) Upper gastrointestinal and overall tolerability of alendronate once weekly in patients with osteoporosis: results of a randomized, double-blind, placebo-controlled study. Curr Med Res Opin 20:699–705PubMedCrossRef Eisman JA, Rizzoli R, Roman-Ivorra J, Lipschitz S, Verbruggen N, Gaines KA, Melton ME (2004) Upper gastrointestinal and overall tolerability of alendronate once weekly in patients with osteoporosis: results of a randomized, double-blind, placebo-controlled study. Curr Med Res Opin 20:699–705PubMedCrossRef
5.
go back to reference Greenspan S, Field-Munves E, Tonino R, Smith M, Petruschke R, Wang L, Yates J, de Papp AE, Palmisano J (2002) Tolerability of once-weekly alendronate in patients with osteoporosis: a randomized, double-blind, placebo-controlled study. Mayo Clin Proc 77:1044–1052PubMed Greenspan S, Field-Munves E, Tonino R, Smith M, Petruschke R, Wang L, Yates J, de Papp AE, Palmisano J (2002) Tolerability of once-weekly alendronate in patients with osteoporosis: a randomized, double-blind, placebo-controlled study. Mayo Clin Proc 77:1044–1052PubMed
6.
go back to reference Pols HA, Felsenberg D, Hanley DA, Stepan J, Munoz-Torres M, Wilkin TJ, Qin-sheng G, Galich AM, Vandormael K, Yates AJ, Stych B (1999) Multinational, placebo-controlled, randomized trial of the effects of alendronate on bone density and fracture risk in postmenopausal women with low bone mass: results of the FOSIT study. Fosamax International Trial Study Group. Osteoporos Int 9:461–468PubMedCrossRef Pols HA, Felsenberg D, Hanley DA, Stepan J, Munoz-Torres M, Wilkin TJ, Qin-sheng G, Galich AM, Vandormael K, Yates AJ, Stych B (1999) Multinational, placebo-controlled, randomized trial of the effects of alendronate on bone density and fracture risk in postmenopausal women with low bone mass: results of the FOSIT study. Fosamax International Trial Study Group. Osteoporos Int 9:461–468PubMedCrossRef
7.
go back to reference Shiraki M, Kushida K, Fukunaga M, Kishimoto H, Taga M, Nakamura T, Kaneda K, Minaguchi H, Inoue T, Morii H, Tomita A, Yamamoto K, Nagata Y, Nakashima M, Orimo H (1999) A double-masked multicenter comparative study between alendronate and alfacalcidol in Japanese patients with osteoporosis. The Alendronate Phase III Osteoporosis Treatment Research Group. Osteoporos Int 10:183–192PubMedCrossRef Shiraki M, Kushida K, Fukunaga M, Kishimoto H, Taga M, Nakamura T, Kaneda K, Minaguchi H, Inoue T, Morii H, Tomita A, Yamamoto K, Nagata Y, Nakashima M, Orimo H (1999) A double-masked multicenter comparative study between alendronate and alfacalcidol in Japanese patients with osteoporosis. The Alendronate Phase III Osteoporosis Treatment Research Group. Osteoporos Int 10:183–192PubMedCrossRef
8.
go back to reference Ferrari AP Jr, Domingues SH (1998) Esophageal ulcer and alendronate. Sao Paulo Med J 116:1882–1884CrossRef Ferrari AP Jr, Domingues SH (1998) Esophageal ulcer and alendronate. Sao Paulo Med J 116:1882–1884CrossRef
9.
go back to reference Nase JB, Suzuki JB (2006) Osteonecrosis of the jaw and oral bisphosphonate treatment. J Am Dent Assoc 137:1115–1119PubMed Nase JB, Suzuki JB (2006) Osteonecrosis of the jaw and oral bisphosphonate treatment. J Am Dent Assoc 137:1115–1119PubMed
10.
go back to reference Maalouf NM, Heller HJ, Odvina CV, Kim PJ, Sakhaee K (2006) Bisphosphonate-induced hypocalcemia: report of 3 cases and review of literature. Endocr Pract 12:48–53PubMed Maalouf NM, Heller HJ, Odvina CV, Kim PJ, Sakhaee K (2006) Bisphosphonate-induced hypocalcemia: report of 3 cases and review of literature. Endocr Pract 12:48–53PubMed
11.
go back to reference Coleman CI, Perkerson KA, Lewis A (2004) Alendronate-induced auditory hallucinations and visual disturbances. Pharmacotherapy 24:799–802PubMedCrossRef Coleman CI, Perkerson KA, Lewis A (2004) Alendronate-induced auditory hallucinations and visual disturbances. Pharmacotherapy 24:799–802PubMedCrossRef
12.
go back to reference Mayoral W, Lewis JH, Zimmerman H (1999) Drug-induced liver disease. Curr Opin Gastroenterol 15:208–216PubMedCrossRef Mayoral W, Lewis JH, Zimmerman H (1999) Drug-induced liver disease. Curr Opin Gastroenterol 15:208–216PubMedCrossRef
14.
15.
go back to reference de La Serna Higuera C, Perez Villoria A, Rodriguez Gomez S, Martinez Moreno J, Betancourt Gonzalez A, Martin Arribas M (2001) Alendronate-induced hepatocellular lesion Gastroenterol Hepatol 24:244–246 de La Serna Higuera C, Perez Villoria A, Rodriguez Gomez S, Martinez Moreno J, Betancourt Gonzalez A, Martin Arribas M (2001) Alendronate-induced hepatocellular lesion Gastroenterol Hepatol 24:244–246
16.
go back to reference Carrere C, Duval JL, Godard B, De Jaureguiberry JP, Ciribilli JM (2002) Severe acute hepatitis induced by alendronate. Gastroenterol Clin Biol 26:179–180PubMed Carrere C, Duval JL, Godard B, De Jaureguiberry JP, Ciribilli JM (2002) Severe acute hepatitis induced by alendronate. Gastroenterol Clin Biol 26:179–180PubMed
Metadata
Title
Hepatotoxicity induced by alendronate therapy
Authors
B. Yanık
C. Turkay
H. Atalar
Publication date
01-06-2007
Publisher
Springer-Verlag
Published in
Osteoporosis International / Issue 6/2007
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-007-0323-2

Other articles of this Issue 6/2007

Osteoporosis International 6/2007 Go to the issue