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01-12-2006 | Review

Osteoporosis prevention and therapy: preserving and building strength through bone quality

Author: M. Kleerekoper

Published in: Osteoporosis International | Issue 12/2006

Abstract

While bone mineral density measurements play a central role in osteoporosis management, the degree to which increases in this parameter contribute to bone fragility, fracture risk, and the therapeutic efficacy of osteoporosis agents is controversial. Indeed, bone strength is also significantly dependent upon bone turnover and bone quality, including microarchitecture, mineralization, and geometry. Given the critical role of these factors, it is essential to understand how they are affected by therapeutic agents. Even though a number of technological advances, such as microcomputed tomography, magnetic resonance imaging, and computerized analysis of radiographic patterns, help to provide critical information toward a more comprehensive assessment of bone turnover and bone quality, clinical trials addressing these factors are scarce. This article provides a review of studies relating to how osteoporosis therapies impact parameters of bone strength and quality.

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Title: Osteoporosis prevention and therapy: preserving and building strength through bone quality
Author: M. Kleerekoper
Publication date: 01-12-2006
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 12/2006
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-006-0187-x

At a glance: The STEP trials

Springer Medicine

Osteoporosis prevention and therapy: preserving and building strength through bone quality

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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