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Osteoporosis International
Published in: Osteoporosis International 1/2006

01-01-2006 | Letter

Obesity susceptibility CART gene polymorphism contributes to bone remodeling in postmenopausal women

Authors: Audrey Guérardel, László B. Tankó, Philippe Boutin, Claus Christiansen, Philippe Froguel

Published in: Osteoporosis International | Issue 1/2006

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Excerpt

Dear Sir, It was recently established by Elefteriou and colleagues [1] in mice that at the level of the central nervous system leptin-regulated neural pathways play a role in the control of bone remodeling and may contribute to bone loss. Conversely, it was suggested that hypothalamic neurones expressing CART (cocaine- and amphetamine-regulated transcript) may counter leptin-induced bone resorption [1]. However, these data obtained from mice apparently contradict the general perception that obese women with high circulating leptin have high bone mineral density (BMD). …
Literature
1.
Elefteriou F, Ahn JD, Takeda S, et al (2005) Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature 434:514–520CrossRefPubMed
2.
Guerardel A, Barat-Houari M, Vasseur F, et al (2005) Analysis of sequence variability in the CART gene in relation to obesity in a Caucasian population. BMC Genet 6:19CrossRefPubMedPubMedCentral
3.
Tanko LB, Bagger YZ, Alexandersen P, Larsen PJ, Christiansen C (2003) Peripheral adiposity exhibits an independent dominant antiatherogenic effect in elderly women. Circulation 107:1626–1631CrossRefPubMed
4.
Metadata
Title
Obesity susceptibility CART gene polymorphism contributes to bone remodeling in postmenopausal women
Authors
Audrey Guérardel
László B. Tankó
Philippe Boutin
Claus Christiansen
Philippe Froguel
Publication date
01-01-2006
Publisher
Springer London
Published in
Osteoporosis International / Issue 1/2006
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-005-2022-1

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