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Osteoporosis International
Published in: Osteoporosis International 1/2006

01-01-2006 | Case Report

Osteoporosis in HFE2 juvenile hemochromatosis. A case report and review of the literature

Authors: Nicholas G. Angelopoulos, Anastasia K. Goula, George Papanikolaou, George Tolis

Published in: Osteoporosis International | Issue 1/2006

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Abstract

Juvenile hemochromatosis (JH) is a severe form of hemochromatosis, which involves rapid iron overload and leads to organ damage, typically before the age of 30. We report a single case of a 25-year-old man suffering from juvenile hemochromatosis, with aggressive clinical manifestations, typically characterized by transaminasemia and progressive erectile dysfunction, due to hypogonadotropic hypogonadism. The clinical case appears interesting, as the patient also had secondary osteoporosis accompanied by increased bone resorption, which prevalently affected trabecular bone. Approximately 6 months after normalization of serum ferritin levels was achieved by frequent phlebotomies, he became eugonadal and bone mineral density of the lumbar spine increased. Our observations suggest that osteoporosis might occur in the state of JH even at a young age, mainly due to the deprivation of sex steroids and the direct tissue toxicity of iron.
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Metadata
Title
Osteoporosis in HFE2 juvenile hemochromatosis. A case report and review of the literature
Authors
Nicholas G. Angelopoulos
Anastasia K. Goula
George Papanikolaou
George Tolis
Publication date
01-01-2006
Publisher
Springer-Verlag
Published in
Osteoporosis International / Issue 1/2006
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-005-1920-6

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